JAHA:肥胖和无脂肪质量与冠状动脉疾病患者长期心血管事件之间的关系!

2018-05-11 xing.T MedSci原创

由此可见,在冠心病患者中,当采用BF%代替体重指数时没有肥胖悖论。BF%与MACE风险较高相关,而无脂肪质量与较低的MACE风险相关。体重指数与MACE无关。

冠状动脉疾病患者基于身体脂肪百分比(BF%)的预后价值尚未进行广泛地研究。近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员测试了这样一个假设:冠心病以及BF%增加的患者发生主要不良心血管事件(MACE)的风险较高,并且无脂肪重量与更好的预后相关。

研究人员纳入了717例冠状动脉疾病事件后心脏康复或接受空气置换体积描记术评估BF%的患者; 75%为男性,平均年龄为61.4±11.4岁,平均体重指数为30±5.4 kg/m2。随访采用记录联动系统进行。研究人员按照性别特异性BF%四分位数和无脂肪质量指数将患者分类。MACE的复合终点包括急性冠状动脉综合征、冠状动脉血运重建、卒中或任何原因引起的死亡。

中位随访3.9年后,201例患者出现MACE。调整协变量后,体重指数与MACE无关(P=0.12)。然而,与最低BF%四分位数的患者相比,最高BF%四分位数患者的MACE风险几乎加倍(风险比为1.89; 95%可信区间为1.30-2.77; P=0.0008)。相反,无脂肪质量与MACE呈负相关。与无脂肪质量第一个四分位数相比,第四个无脂肪质量四分位数组的MACE风险较低(校正风险比为0.53,95%可信区间为0.35-0.82; P=0.004)。

由此可见,在冠心病患者中,当采用BF%代替体重指数时没有肥胖悖论。BF%与MACE风险较高相关,而无脂肪质量与较低的MACE风险相关。体重指数与MACE无关。

原始出处:

Jose R. Medina‐Inojosa,et al.Association Between Adiposity and Lean Mass With Long‐Term Cardiovascular Events in Patients With Coronary Artery Disease: No Paradox, JAHA.2018. https://doi.org/10.1161/JAHA.117.007505

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    2018-05-17 12177770m58暂无昵称

    不错的学习

    0

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  5. [GetPortalCommentsPageByObjectIdResponse(id=1643535, encodeId=019c164353510, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sun Dec 16 22:48:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799043, encodeId=97291e9904317, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Apr 21 11:48:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316059, encodeId=eadb316059b4, content=不错的学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d12257050, createdName=12177770m58暂无昵称, createdTime=Thu May 17 17:16:59 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252914, encodeId=484512529140b, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun May 13 00:48:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267811, encodeId=996d126e8114c, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun May 13 00:48:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314409, encodeId=6126314409d4, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat May 12 08:58:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314284, encodeId=884931428493, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat May 12 02:18:07 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314150, encodeId=f1ff3141504e, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri May 11 13:30:27 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-13 仁者大医
  6. [GetPortalCommentsPageByObjectIdResponse(id=1643535, encodeId=019c164353510, content=<a href='/topic/show?id=6236895092b' target=_blank style='color:#2F92EE;'>#血管事件#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89509, encryptionId=6236895092b, topicName=血管事件)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f99523187183, createdName=hukaixun, createdTime=Sun Dec 16 22:48:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1799043, encodeId=97291e9904317, content=<a href='/topic/show?id=38e0e0670ff' target=_blank style='color:#2F92EE;'>#疾病患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70670, encryptionId=38e0e0670ff, topicName=疾病患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c859411, createdName=hmwwww, createdTime=Sun Apr 21 11:48:00 CST 2019, time=2019-04-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316059, encodeId=eadb316059b4, content=不错的学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=50, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=76d12257050, createdName=12177770m58暂无昵称, createdTime=Thu May 17 17:16:59 CST 2018, time=2018-05-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1252914, encodeId=484512529140b, content=<a href='/topic/show?id=463230886b8' target=_blank style='color:#2F92EE;'>#冠状动脉疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=30886, encryptionId=463230886b8, topicName=冠状动脉疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Sun May 13 00:48:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1267811, encodeId=996d126e8114c, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=8e886, createdName=仁者大医, createdTime=Sun May 13 00:48:00 CST 2018, time=2018-05-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314409, encodeId=6126314409d4, content=一起学习学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=48, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/vi_32/TDiaAWyicHgedzX3wKo3qcxudVJib7AfibfvNeufHRF2jG3Bw8MmZyWjIhtBV1mpJI7Sy9n7RcBKK5t3CuOKuOFxkg/0, createdBy=dd702206933, createdName=wzb521zf, createdTime=Sat May 12 08:58:45 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314284, encodeId=884931428493, content=学习了.谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=7c592194322, createdName=1209e435m98(暂无昵称), createdTime=Sat May 12 02:18:07 CST 2018, time=2018-05-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=314150, encodeId=f1ff3141504e, content=有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=18741984753, createdName=smartxiuxiu, createdTime=Fri May 11 13:30:27 CST 2018, time=2018-05-11, status=1, ipAttribution=)]
    2018-05-12 wzb521zf

    一起学习学习

    0

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    2018-05-12 1209e435m98(暂无昵称)

    学习了.谢谢分享

    0

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    2018-05-11 smartxiuxiu

    有用

    0

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肥胖已成为全球性的健康问题,大量证据显示肥胖人群有更高罹患结肠癌的风险,而结肠组织炎症是结肠癌的主要风险因素。30日发表在美国《国家科学院学报》杂志上的一项研究揭示了肥胖增加结肠组织炎症的新分子机制。

Diabetes:科学家发现脂肪氧化应激加剧代谢恶化的新机制

最近一些研究发现脂肪组织氧化应激与肥胖疾病中发生的代谢紊乱存在相关性,因为缺少能够在脂肪细胞中特异性改变氧化应激状态的小鼠模型,脂肪氧化应激与代谢紊乱在体内状态下的因果关系仍然没有得到揭示。最近来自日本的研究人员构建了脂肪特异性氧化应激清除和增强小鼠模型对氧化应激在饮食诱导肥胖相关的代谢紊乱中的作用进行了观察。相关研究结果发表在国际学术期刊Diabetes上。

Nature:靠吃药就能不饿?科学家们向前迈进重要一步

最新发表在Nature杂志上的一项研究中,一个国际科学家小组在对抗肥胖研究方向上取得突破进展,首次描述了一种复杂的、被激活后能够抑制饥饿的受体的关键结构信息,为治疗肥胖、糖尿病等疾病的药物研发提供了重要的依据。

J Clin Invest:新研究揭示胰岛素抵抗与脂肪组织炎症的因果关系

肥胖诱导的胰岛素抵抗是2型糖尿病、高脂血症、心血管疾病和一些癌症类型发生的主要风险因素,肥胖引起胰岛素抵抗的机制到目前为止仍不明确。许多研究表明炎症与局部和系统性胰岛素抵抗的发生有关,特别是当炎症发生在白色脂肪组织当中,但是这些事件的因果关系还不清楚。在最近发表在国际学术期刊JCI上的一项研究中,来自瑞士的研究人员发现脂肪组织的胰岛素抵抗导致了局部炎症的发生,并非炎症导致了脂肪组织的胰岛素抵抗。

PLOS ONE:食用酵母产生的寡糖具有免疫调节作用

由于炎症是与肥胖相关代谢功能障碍的发生有关的潜在机制之一,来自莱顿大学医学中心的研究人员进行了一项探究,旨在确定膳食补充MOS对纤瘦的和饮食诱导的肥胖小鼠的炎症和代谢稳态的影响。