Diabetologia:糖尿病女性妊娠早期白大衣高血压的患病率和妊娠结局如何?

2019-12-28 MedSci MedSci原创

在患有糖尿病病史的孕妇中,高血压疾病普遍存在,但白大衣高血压的患病率和影响尚不清楚。由于国际指南建议对白大衣高血压不予治疗,在开始降压治疗之前必须测量家庭血压以识别白大衣高血压。

在患有糖尿病病史的孕妇中,高血压疾病普遍存在,但白大衣高血压的患病率和影响尚不清楚。由于国际指南建议对白大衣高血压不予治疗,在开始降压治疗之前必须测量家庭血压以识别白大衣高血压。 因此,本研究针对先前患有糖尿病的女性进行研究,目的是检查妊娠早期白大衣高血压患病率以及妊娠早期白大衣高血压妇女的妊娠结局

研究人员进行了一项前瞻性队列研究,涉及来自地理明确区域的既往患有糖尿病的妇女。 根据怀孕初期的办公室血压和测量的3天家庭血压,将女性分为三组:(1)白大衣高血压,定义为办公室BP≥135/ 85 mmHg,平均家庭BP≤130/ 80 mmHg 2)慢性高血压,定义为孕前高血压,包括新发现的办公室BP≥135/85 mmHg和家庭BP≥130/80 mmHg 3)血压正常。 每两周测量一次办公室血压,如果≥135/85 mmHg,则进行家庭血压测量。 白大衣的高血压不予治疗,当办公室血压≥135/85 mmHg和家庭血压≥130/80 mmHg时,开始严格的降压治疗。 怀孕引起的高血压疾病定义为办公室BP≥140/90 mmHg,家中BP≥130/80 mmHg(如果可用),在妊娠20周后开始出现症状。

222名患有糖尿病的女性中,有32人在妊娠早期新检测到血压≥135/85 mmHg。在84%(27/32)的女性中有白大衣高血压,占整个队列的12% (95% CI 8% 17%)。慢性高血压患者占14%(32),正常血压患者占74%(163)。白大衣高血压妇女的特点是孕前BMI (p = 0.011)、家庭血压(p < 0.001)2型糖尿病患病率(p = 0.009)较高,但糖化血红蛋白(p = 0.409)与正常妊娠妇女相似。在妊娠结局方面,44%(12/27)的白大衣高血压妇女发生妊娠性高血压疾病,而初始血压正常的妇女发生妊娠性高血压疾病的比例为22% (36/163)(p = 0.013),而早产的患病率不相上下(p = 0.143)。校正分析表明,如果在妊娠早期存在白大褂高血压,那么发生妊娠期高血压病的风险约为妊娠期高血压病风险的两倍(2.43 [CI 0.98, 6.05]),而与妊娠前BMI和产次无关。

研究结果表明,在有糖尿病病史的女性中白大衣高血压普遍存在,并且可能预示着妊娠诱发的高血压疾病后来发展的高风险。 为了区分持续性白大衣高血压和妊娠高血压引起的高血压,当检测到办公室血压升高时,建议重复家庭血压监测。

原始出处:

Marianne VestgaardBjörg ÁsbjörnsdóttirWhite coat hypertension in early pregnancy in women with pre-existing diabetes: prevalence and pregnancy outcomes

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    2019-12-28 misszhang

    谢谢MedSci提供最新的资讯

    0