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J Dent Res：NOTCH通路在头颈鳞状细胞癌中的研究进展

2018-05-22 lishiting MedSci原创

头颈鳞状细胞癌Notch
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对头颈鳞状细胞癌(HNSCC)广泛、深入的基因组学研究发现，NOTCH1突变率极高并验证了NOTCH1为继TP53后的第二个最常发生突变的基因。

对头颈鳞状细胞癌(HNSCC)广泛、深入的基因组学研究发现，NOTCH1突变率极高并验证了NOTCH1为继TP53后的第二个最常发生突变的基因。

大多数NOTCH1突变被认为是钝化的，表明NOTCH1为肿瘤抑制基因。另一方面，对亚洲人群HNSCC的队列研究发现，NOTCH1突变具有一定的活性。HNSCC伴随NOTCH1突变的预后要差于野生型NOTCH1肿瘤。另外，对其他NOTCH家族成员的研究显示，NOTCH会促进HNSCC的进程。NOTCH家族成员并包括NOTCH通路基因，与正常组织相比在HNSCC中明显上调，并且抑制NOTCH通路会减弱细胞的增殖和侵袭。因此，NOTCH在HNSCC中的活性具有上下文相关性，并且NOTCH在HNSCC中被认为具有肿瘤抑制和癌基因的双重作用模式。

这篇综述阐述了近来对NOTCH通路基因的研究进展，包括HNSCC中的NOTCH基因。并论证了NOTCH通路变化对探索HNSCC特异性的NOTCH靶向肿瘤疗法的意义。

原始出处：

Fukusumi T， Califano JA．The NOTCH Pathway in Head and Neck Squamous Cell Carcinoma.　J Dent Res. 2018 Jun；97(6)：645-653. doi： 10.1177/0022034518760297. Epub 2018 Feb 28.

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    2018-06-15 qingting

    #细胞癌#

    0

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    2018-05-24 karmond

    #Notch#

    0

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    2018-05-24 mashirong

    #研究进展#

    0

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    2018-05-24 ymljack

    #OTC#

    0

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    2018-05-24 ms55066533437992

    #头颈鳞状细胞癌#

    0

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    2018-05-23 kafei

    学习了谢谢

    0

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    2018-05-22 有备才能无患

    对头颈鳞状细胞癌(HNSCC)广泛.深入的基因组学研究发现.NOTCH1突变率极高并验证了NOTCH1为继TP53后的第二个最常发生突变的基因.

    0

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    2018-05-22 清风拂面

    谢谢分享学习

    0

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