JAMA:激素预防绝经后女性的慢性病真的合适么?

2017-12-15 MedSci MedSci原创

女性发生绝经的中位年龄为51.3岁,美国女性达到更年期的平均年龄后预计还会再活30年。大多数慢性疾病,如冠心病、痴呆、中风、骨折和乳腺癌的患病率和发病率随年龄而增加;然而,单单因为更年期的发生而导致这些疾病的风险是不确定的。自从“妇女健康倡议”发现激素疗法的使用与绝经后妇女的严重不良健康影响相关以来,使用绝经后激素治疗的患者比例下降。近期,一篇发表在权威杂志JAMA上的文章更新例2012年美国预防

女性发生绝经的中位年龄为51.3岁,美国女性达到更年期的平均年龄后预计还会再活30年。大多数慢性疾病,如冠心病、痴呆、中风、骨折和乳腺癌的患病率和发病率随年龄而增加;然而,单单因为更年期的发生而导致这些疾病的风险是不确定的。自从“妇女健康倡议”发现激素疗法的使用与绝经后妇女的严重不良健康影响相关以来,使用绝经后激素治疗的患者比例下降。近期,一篇发表在权威杂志JAMA上的文章更新例2012年美国预防服务工作组(USPSTF)有关使用绝经期激素治疗慢性病初级预防的建议。USPSTF审查了全身(即口服或透皮)激素治疗预防绝经后妇女慢性病的好处和危害的证据,以及不同亚组妇女的结局是否有所不同,或绝经后的干预时机。在该综述中没有提到激素治疗预防或治疗更年期的症状。此篇研究发现,虽然使用激素疗法预防绝经后妇女的慢性病有一些好处,但也有很好的证据表明了其带来的危害。 USPSTF确定,绝经后妇女激素治疗的好处和危害的程度都是轻微的。因此,USPSTF以中度确定性得出的结论认为,雌激素和孕激素联合治疗对大多数绝经后子宫完好状态女性的慢性病的初级预防没有净益处,而单用雌激素对大多数绝经后已经做了子宫切除

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    2017-12-27 zwjnj2

    好好好学习学习

    0

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    2017-12-18 1209e435m98(暂无昵称)

    学习了.谢谢分享!

    0

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    2017-12-17 qjddjq
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    2017-12-17 zxxiang
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    2017-12-16 thlabcde

    好资料学习了!

    0

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    2017-12-15 有备才能无患

    女性发生绝经的中位年龄为51.3岁.美国女性达到更年期的平均年龄后预计还会再活30年.大多数慢性疾病.如冠心病.痴呆.中风.骨折和乳腺癌的患病率和发病率随年龄而增加,然而.单单因为更年期的发生而导致这些疾病的风险是不确定的.自从[妇女健康倡议"发现激素疗法的使用与绝经后妇女的严重不良健康影响相关以来.使用绝经后激素治疗的患者比例下降.

    0

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    2017-12-15 神功盖世

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