JCC:吸烟与结肠炎风险增加相关:美国妇女的两项大型前瞻性队列研究结果

2018-05-20 MedSci MedSci原创

目前对于有关吸烟对微小结肠炎风险影响的长期数据十分有限。因此,研究人员试图在两个大型前瞻性队列的妇女中研究和描述吸烟与偶发性微小结肠炎风险之间的关系。

背景
目前对于有关吸烟对微小结肠炎风险影响的长期数据十分有限。因此,研究人员试图在两个大型前瞻性队列的妇女中研究和描述吸烟与偶发性微小结肠炎风险之间的关系。

方法
研究人员对231015名参加护士健康研究NHS和NHSII的女性进行了前瞻性研究。关于吸烟,其他生活方式因素和药物的信息每两年从NHSII的NHSII从1976年到2012年收集,1989年至2013年收集。通过保留的切片审查证实了显微镜下结肠炎的事件病例。研究人员使用Cox比例风险模型来检验吸烟与微观结肠炎风险之间的关系。

结果
我们记录了超过6122779人年随访的166例微小结肠炎事件。与非吸烟者相比,目前吸烟者的显微镜下结肠炎的多变量校正风险比HR为2.52(CI 1.59-4.00),过去吸烟者为1.54 95%CI 1.09-2.17。随着吸烟年数增加?p= 0.001,戒烟后戒烟p= 0.017减少,风险增加。目前吸烟与胶原性结肠炎的风险似乎更为密切HR 3.68;95%CI 1.94-6.97比淋巴细胞性结肠炎HR 1.71;95%CI 0.83-3.53。

结论
在两项大型前瞻性队列研究中,研究人员观察到吸烟与微小结肠炎风险之间的关联。显微镜下结肠炎的风险似乎随着年数增加而增加,在戒烟后减少。

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    2018-05-20 flysky120

    全国都应该禁烟的.吸烟没有任何好处

    0

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