JACC:IL-8水平与心梗患者的临床预后相关

2018-07-07 MedSci MedSci原创

目前,关于白介素-8(IL-8)在急性ST段抬高型心梗(STEMI)患者中的作用尚不清楚。本研究的目的旨在评估STEMI患者IL-8水平的变化情况及其可能与左室功能、梗死面积、微血管梗阻和临床预后的关系。本研究纳入了258名STEMI患者,在其接受经皮冠脉介入治疗(PCI)前、术后即刻、术后1天和术后4个月各抽了血样,并在急性期和术后4个月对患者进行了心脏磁共振检查。分析结果显示,IL-8高于平均

目前,关于白介素-8(IL-8)在急性ST段抬高型心梗(STEMI)患者中的作用尚不清楚。本研究的目的旨在评估STEMI患者IL-8水平的变化情况及其可能与左室功能、梗死面积、微血管梗阻和临床预后的关系。

本研究纳入了258名STEMI患者,在其接受经皮冠脉介入治疗(PCI)前、术后即刻、术后1天和术后4个月各抽了血样,并在急性期和术后4个月对患者进行了心脏磁共振检查。分析结果显示,IL-8高于平均水平的患者心肌梗死面积更大,左室射血分数更低,左室舒张末期容积更大,且微血管梗阻的频率更大。经多元分析调整后,术后1天IL-8水平的增高与术后4个月梗死面积增大和左室射血分数降低呈相关性。另外,在所有时间点IL-8水平都处于最高区间的患者心梗后12个月发生不良事件的风险更高,生存率更低。

本研究结果显示,急性ST段抬高型心梗患者IL-8水平的增高与不良预后相关,提示IL-8可作为治疗心梗靶标。

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    2018-12-14 hbwxf
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    2018-07-09 respect
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    2018-07-07 张新亮1853311252142e2fm

    好文献学习了

    0

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    2018-07-07 虈亣靌

    学习学习学习

    0

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