JAHA:心肌离子通道病患者可放心接受牙科治疗

2019-07-26 国际循环编辑部 国际循环

约1/3不明原因心脏猝死由Brugada综合征和长-QT间期综合征所致。由于使用利多卡因带来的潜在生命危险,心肌离子通道疾病患者通常对牙科治疗存在顾虑。近期发表于《美国心脏协会杂志》(Journal of the American Heart Association)的研究提示,利多卡因联合或不联合肾上腺素进行局部牙科麻醉是安全的,不会导致通道病变患者出现危及生命的心律失常。

约1/3不明原因心脏猝死由Brugada综合征和长-QT间期综合征所致。由于使用利多卡因带来的潜在生命危险,心肌离子通道疾病患者通常对牙科治疗存在顾虑。近期发表于《美国心脏协会杂志》(Journal of the American Heart Association)的研究提示,利多卡因联合或不联合肾上腺素进行局部牙科麻醉是安全的,不会导致通道病变患者出现危及生命的心律失常。

我们进行了一项随机双盲单中心试验,比较2个牙齿修复疗程中分别使用无血管收缩剂2%利多卡因和1:100 000肾上腺素(交叉试验)治疗后7天洗脱期的情况。对受试者进行8~12小时动态心电图监测,并在3个时间点进行12导联心电图、数字血压计和焦虑量表评估。结果显示,共28例患者(18例女性,10例男性)接受56次牙科手术,其中16例(57.1%)为长QT综合征,12例(42.9%)为Brugada综合征,11例(39.3%)植入除颤器,平均年龄为(45.9±15.9)岁。麻醉期间使用肾上腺素后最大心率由每分钟82.1次增加到每分钟85.8次(P=0.008)。在长QT间期综合征患者中,使用肾上腺素至麻醉结束时QT间期校正均值较高,为450.1~465.4 ms (P=0.009)。其他测量结果无显著统计学差异。此外,牙科手术治疗期间没有发生危及生命的心律失常。

无论使用血管收缩剂与否,牙科手术使用利多卡因行局部麻醉均不会导致危及生命的心律失常。研究人员认为,基于当前证据,可以认为稳定性心脏通道病变患者进行牙科手术是安全的。

原始出处:
Ana Carolina Guimarães Oliveira, Itamara Lucia Itagiba Neves, et al. Is It Safe for Patients With Cardiac Channelopathies to Undergo Routine Dental Care? Experience From a Single‐Center Study. Journal of the American Heart Association. Originally published19 Jul 2019.

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    2019-07-28 zhaohui6731
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    2019-07-28 zhaojie88
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    2019-07-28 小微940490

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