Neurology:认知正常人群痴呆风险与认知能力评估、脑脊液标志物及脑神经血管负担之间的关系

2018-06-14 zhangfan MedSci原创

研究发现,痴呆风险高的健康人群其执行控制操作,视觉感知与建构能力下降,其下降程度与APOE基因型、脑白质病变以及阿尔兹海默标志物相关

近日研究人员就心血管危险和衰老相关痴呆(CAIDE)危险评分升高的健康人群的认知特征进行了考察,并考察上述特征与淀粉样病变、神经变性血管病变和脑脊液生物标志物之间的关系。

认知正常的参与者,以CAIDE得分9为限度,分为痴呆高风险(HR;n = 82)和低风险(LR;n = 293)人群,接受认知能力考察。研究人员采用广义线性模型考察了APOE基因型、MRI白质高信号(WMH)、脑脊液Aβ1-42、总tau蛋白(t-tau)以及磷酸化tau蛋白(p-tau)与CAIDE得分和认知之间的关系。

HR人群其执行控制操作(EF),视觉感知与建构(VPC)得分降低。在调整年龄、受教育程度、性别、病态前智力和压力等因素后,EF得分与CAIDE得分× p-tau 水平交互作用(p = 0.001), CAIDE 得分 × t-tau水平 (p = 0.001) 交互作用以及 WMH 程度(p = 0.003)相关。VPC与APOE 基因型(p = 0.001), Aβ1-42含量 (p = 0.004), APOE × Aβ1-42交互作用(p = 0.003)以及WMH程度 (p = 0.004)相关。全脑记忆表现与Aβ1-42含量 (p = 0.006),APOE (基因型p = 0.008)及其交互作用(p = 0.006)相关。

研究发现,痴呆风险高的健康人群其执行控制操作,视觉感知与建构能力下降,其下降程度与APOE基因型、脑白质病变以及阿尔兹海默标志物相关。

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    2018-11-22 yinhl1978
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    2019-03-04 siiner
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    2018-06-14 邓启付

    这项研究实际操作起来比较复杂.

    0

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