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Cancer Res ：研究显示TET通过miR-26介导EZH2表达参与胃癌发生

2017-11-25 Emma MedSci原创

癌症胃癌TETmiR-26Ezh2
关注

胃癌是消化道最常见的肿瘤，目前已知胃癌的发病常与慢性胃炎、胃息肉、胃溃疡、饮食、环境、遗传等因素有关。

胃癌是消化道最常见的肿瘤，目前已知胃癌的发病常与慢性胃炎、胃息肉、胃溃疡、饮食、环境、遗传等因素有关。胃是人体重要的消化器官之一，胃癌术后胃的运动、贮存及分泌功能发生了不同程度的变化。

近年来许多学者认为环境因素，特别是环境中很多化学物质如亚硝基化合物（主要存在于腌制食品中）和多环芳羟类化合物等与胃癌的发病关系非常密切。此外，还与人的饮食方式、生活习惯、营养状况、精神状态等诸多因素相关。生物致病因素中真菌感染和幽门螺旋杆菌（HP）感染研究较深入，但目前还不能证实HP为胃癌的直接致病因素。研究提示，TET家族的DNA脱甲基酶与人类多个癌症相关，但是其在胃癌发生发展中的致病作用及其机制仍不清楚。

研究显示，在胃癌中TET转录上调，并且与预后不良相关。探究其机制时发现，TET能够通过与miR-26的3'UTR的非编码相互作用促进胃癌发生，同时这种相互作用也导致miR-26靶向释放对EZH2的抑制，导致EZH2在胃癌中过表达。该研究表明，TET→miR-26→EZH2途径促进胃癌发生，也揭示了TET家族蛋白在促进胃癌发生中新的非编码功能。

原始出处：
Deng M, et al. TET-Mediated Sequestration of miR-26 Drives EZH2 Expression and Gastric Carcinogenesis. Cancer Res. 2017 Nov 15;77(22):6069-6082. doi: 10.1158/0008-5472.CAN-16-2964. Epub 2017 Sep 18.

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    2018-10-06 zhaojie88

    #TET#

    0

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    2018-10-20 fusion

    #Ezh2#

    0

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    2018-04-27 smallant2002

    #miR#

    0

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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-12-07 jyzxjiangqin

    胃癌发生机制.

    0

  5. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-28 jyzxjiangqin

    TET道过参与胃癌发生表达.

    0

  6. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-27 yfjms

    学习

    0

  7. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 cscdliu

    文章很好.学习了

    0

  8. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 惠映实验室

    学习了.谢谢.

    0

  9. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 1ddf0692m34(暂无匿称)

    学习了.涨知识

    0

  10. 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topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sat Nov 25 18:28:04 CST 2017, time=2017-11-25, status=1, ipAttribution=)]
    2017-11-25 1dd8c52fm63(暂无匿称)

    学习学习.了解了解

    0

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