JAMA Oncol:历时20多年、12万人研究揭秘哪些食物能增加结直肠癌风险

2018-01-20 Yui 转化医学网

最近结直肠癌领域硕果累累,在昨日的转化医学网上我们刚刚报道过二甲双胍可拮抗结直肠癌,而今日JAMA又出大数据研究报道:红肉、白面包和含糖饮料可增加患结直肠癌的风险。

最近结直肠癌领域硕果累累,今日JAMA又出大数据研究报道:红肉、白面包和含糖饮料可增加患结直肠癌的风险。

结肠直肠癌是胃肠道中常见的恶性肿瘤,虽然早期症状不明显,但随其逐渐增大患者会表现出排便习惯改变、便血、腹泻、腹泻与便秘交替、局部腹痛等症状,到了晚期则会有贫血、体重减轻等全身症状。而结肠直肠癌的发病率和病死率在消化系统恶性肿瘤中仅次于胃癌、食管癌和原发性肝癌!

那么做到防范于未然,在源头遏制住结直肠癌的种子就显得尤为重要。这不,JAMA在1月18日就发表了一篇超12万人,跨越四分之一世纪的大数据研究 “Association of Dietary Inflammatory Potential With Colorectal Cancer Risk in Men and Women”,其研究数据告诉我们:长期食用红肉,白面包和含糖饮料可能会增加患结直肠的风险!

吃得不对会诱发炎症?

以往的研究早已经将饮食和结直肠癌的关系联系起来,但并没有明确的解释为什么会这样。Giovannucci和他的同事对此则提出了这样一个理论:饮食影响癌症风险可能是因为某些食物会诱发炎症。而多伦多大学外科教授Nancy Baxter博士也支持这一观点,持续的慢性炎症并不是正常的状态,而且炎症对人体的影响也不仅仅是癌症。

而这篇研究为我们解开了饮食与癌症之间的面纱。

研究人员每四年以问卷的形式调查参与者的饮食,而在这二十多年的调查期间,这12万人间共有2699人发生了结直肠癌。

炎症饮食在结直肠癌中被证实

通过分析比较这2699例结直肠癌患者与正常人之间的饮食结构。我们可以看到:吃那些“炎性食物”最多的人与吃“炎性食物”最少的人相比,前者发生结肠癌的概率增加了37%!发生直肠癌的概率增加了70%!

炎性食物?

那么什么样的食物是“炎性食物”呢?Giovannucci指出,加工过的肉类,红肉,内脏,精制面粉和含糖饮料是与癌症相关炎症最相关的食物,称之为“炎性食物”。

而与“炎性食物”相对的是:绿叶蔬菜,深黄色蔬菜,全谷物,咖啡和果汁。这些食物可以帮助我们减少炎症。如果在常吃这些食物的基础上,同时也不饮酒的话,那你就拥有了最佳的抗炎效果!

披萨也能抵抗炎症?

然而令人意外的是,炎性食物的分界似乎并没有那么清晰。披萨相对而言是一种不那么健康的食物,它拥有精致面粉,可能也会放上加工过的肉类比如香肠。但根据研究数据表示,披萨站在抵抗炎症这一阵营中。

Giovannucci解释说:“单一的因素虽然有用,但是人不可能只吃一种食物,喝一大杯咖啡会对消炎有帮助,但如果你往咖啡里加入了大量的糖,那它的消炎作用将大大降低。” 因此,对于抵抗炎症,我们不能只看某一食物,而应该将整体的饮食习惯变得更加健康。

重要的是那些整体上促进炎症的饮食习惯,长期、大量、高频地摄入炎性食物,同时饮食不规律等。而在这篇研究中,最易患结肠癌的那五分之一的参与者就拥有以上的饮食习惯。

所以,即使我们知道了哪些食物可促进炎症,哪些食物可抵抗炎症,但若没有一个规律,健康的饮食习惯,就算食用消炎食物,其功效也会事倍功半。

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    2018-05-14 minlingfeng
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    2018-11-21 sjq027
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time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280260, encodeId=9006280260f7, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jan 20 07:51:54 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-22 chunjianf

    学习了.谢谢分享

    0

  5. 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time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280260, encodeId=9006280260f7, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jan 20 07:51:54 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-21 yhy100201
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  7. 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time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280260, encodeId=9006280260f7, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jan 20 07:51:54 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 明月清辉

    谢谢分享.学习了

    0

  8. 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time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280260, encodeId=9006280260f7, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jan 20 07:51:54 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 衣带渐宽

    学习

    0

  9. 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time=2018-01-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=280260, encodeId=9006280260f7, content=学习一下知识了, beContent=null, objectType=article, channel=null, level=null, likeNumber=63, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160718/IMG578C993D395567540.jpg, createdBy=59b81918946, createdName=flysky120, createdTime=Sat Jan 20 07:51:54 CST 2018, time=2018-01-20, status=1, ipAttribution=)]
    2018-01-20 龙胆草

    学习谢谢分享

    0

  10. 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    2018-01-20 flysky120

    学习一下知识了

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