SCI REP:同型半胱氨酸与无症状高血压患者ECAS和ICAS之间相关性分析!

2018-01-14 xing.T MedSci原创

由此可见,该研究结果表明同型半胱氨酸与无症状高血压患者ECAS和ICAS之间存在显著关联。Hcy对颈脑动脉粥样硬化具有广泛的效应,这种相关性可由MTHFR C677T基因型所改变。

血浆同型半胱氨酸(Hcy)升高是卒中的独立危险因素。近日,Scientific reports杂志上针对这一问题发表了一篇研究文章,研究人员的目的是探讨Hcy浓度与无卒中高血压患者颅内动脉粥样硬化(ICAS)和颅外动脉粥样硬化(ECAS)之间的关系,并探讨亚甲基四氢叶酸还原酶(MTHFR)对改变这种相关性的效果。

研究人员通过计算机断层血管造影(CTA)对929例受试者主动脉弓至颅底的颅内外动脉狭窄进行了评价。

研究人员发现Hcy浓度与ICAS(Hcy增加1µmol/L对应的比值比为1.105;95%可信区间为1.057-1.155)和ECAS(比值比为1.096;95%可信区间为1.047-1.146)。同时,经过充分调整后,高同型半胱氨酸血症(≥15µmol/L)也显示与ICAS(比值比为1.587;95%可信区间为1.0292.446)和ECAS(比值比为2.164;95%可信区间为1.392-3.364)相关。此外,在亚组分析中,只有在年轻的、肾功能正常、携带MTHFR 677 C等位基因的受试者中这种相关性仍然显著。

由此可见,该研究结果表明同型半胱氨酸与无症状高血压患者ECAS和ICAS之间存在显著关联。Hcy对颈脑动脉粥样硬化具有广泛的效应,这种相关性可由MTHFR C677T基因型所改变。

原始出处:


Yan Wang,et al. Association of Homocysteine with Aysmptomatic Intracranial and Extracranial Arterial Stenosis in Hypertension Patients.Scientific reports. 2018. https://www.nature.com/articles/s41598-017-19125-9

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    2018-02-15 方舒

    学习

    0

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createdBy=411420689333, createdName=yaanren, createdTime=Tue Jan 16 05:56:00 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-20 大爰

    学习了谢谢分享!!

    0

  5. 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createdBy=411420689333, createdName=yaanren, createdTime=Tue Jan 16 05:56:00 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 手留余香
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  9. 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createdBy=411420689333, createdName=yaanren, createdTime=Tue Jan 16 05:56:00 CST 2018, time=2018-01-16, status=1, ipAttribution=)]
    2018-01-16 yaanren

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