JAMA:吸入亚硝酸盐不能提高心衰患者的运动能力

2018-11-13 zhangfan MedSci原创

研究认为,心衰患者吸入亚硝酸盐不能显著改善其运动能力

以保留射血分数为治疗目标的心力衰竭(HFpEF)治疗方案十分有限,短期服用无机亚硝酸盐或硝酸盐制剂可增强一氧化氮信号,具有潜在的提高HFpEF有氧能力的效果。近日研究人员开展为期4周的研究,考察雾化吸入无机亚硝酸盐对HFpEF的影响。

105名心衰患者参与研究,随机通过微针装置雾化吸入无机亚硝酸盐或安慰剂,每6周为1个治疗疗程,患者首先接受1周,46mg每日3次的治疗,随后3周接受80mg,每日3次的治疗,之后进入2周的空白期,随后进行交叉。研究的主要终点为氧耗峰值(mL/kg/min),次要终点包括每日活动水平、健康状况、功能分级、超声心动图心脏充盈压力评估、前激素脑钠素N端片段水平、其他运动指标、不良事件和耐受性。

105名患者参与研究,平均年龄68岁,93%完成研究,接受亚硝酸盐的患者其氧耗峰值未见显著增加(13.5 vs 13.7)。在治疗空白期,组间每日活动水平、健康状况、功能分级、超声心动图心脏充盈压力评估、前激素脑钠素N端片段水平也未见显著差异。3名患者(2.9%)在治疗期,8人(7.6%)在空白期病情加重。

研究认为,心衰患者吸入亚硝酸盐不能显著改善其运动能力。

原始出处:


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    2019-08-01 paperyu
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    2018-11-22 zwjnj2

    好好学习天天学习

    0

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