J Exp Clin Canc Res:CAR T细胞治疗火热,其靶向生物标志物的研究呈指数级增长态势

2018-09-23 BMC中国 BMC期刊

Journal of Experimental&Clinical Cancer Research于7月发表了一篇综述:The expansion of targetable biomarkers for CAR T cell therapy。作者讨论了目前研究较多的CAR T靶向生物标志物,并着重指出一些未来将有望成为治疗靶点的生物标志物。

Journal of Experimental&Clinical Cancer Research于7月发表了一篇综述:The expansion of targetable biomarkers for CAR T cell therapy。作者讨论了目前研究较多的CAR T靶向生物标志物,并着重指出一些未来将有望成为治疗靶点的生物标志物。

生物标志物可用于肿瘤风险评估、筛查、鉴别诊断、预后判断、疗效预测以及疾病进展的监测,是肿瘤治疗不可或缺的一部分。最近,随着嵌合抗原受体(CAR)T细胞疗法的出现,人们发现了一类新的靶向生物标志物。这些生物标志物多在肿瘤细胞表面,可作为细胞毒性T细胞的靶点。



图1 癌症生物标志物的应用

首个用于CAR T细胞治疗的靶向生物标志物为CD19,这是一种在恶性B细胞上高度表达的B细胞标志物。随着CD19的成功发现,在过去的十年中,又在一系列人类恶性肿瘤中发现了大量新的靶向生物标志物。



图2. 目前在临床试验中用到的CAR T细胞

它们的出现使得人们开展定向的、特定的治疗成为可能,从而减少了对健康组织的破坏,并尽可能在治疗期间保护了患者的免疫系统。



图3. 截至2018年5月在临床实验中用到的生物标志物种类剧增、数量呈指数增长

截至2018年5月,共有100多项临床试验正在进行,涉及的表面生物标志物超过25种,研究几乎涵盖了人体的每种组织。大量临床试验的开展不仅在患者临床结局方面带来了可喜的结果,同时也使得探索可用于CAR T治疗的新型生物标志物的研究数量呈现指数级增长。

原始出处:
Michelle H. Townsend, Gajendra Shrestha, Richard A. Robison, et al. The expansion of targetable biomarkers for CAR T cell therapy. Journal of Experimental & Clinical Cancer Research. July 2018.

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    2018-09-24 kafei

    学习了谢谢

    0

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    2018-09-23 1e145228m78(暂无匿称)

    学习了,谢谢作者分享!

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