Hypertension:短期血压变异与高血压患者预后之间的相关性

2020-01-28 xing.T MedSci原创

由此可见,高血压患者短期血压变异性与总死亡率和心血管死亡率独立相关。

高血压患者短期血压(BP)变异性与预后之间的相关性尚未明确。近日,心血管权威杂志Hypertension上发表了一篇研究文章,研究人员旨在评估通过动态BP监测评估的短期BP变异性与高血压患者总死亡率和心血管死亡率之间的相关性。

研究人员从西班牙ABPM注册中心选择了2004年至2014年期间的63910名受试者,平均随访时间为4.7年。受试者在基线时进行24小时动态BP监测计算24小时、白天和夜间的收缩压和舒张压SD、加权SD(在一段时间内加权的白天和夜间SD的平均值)、平均实际变异性(连续读数之间的差异的平均值)、独立于平均值的变异性和BP变异性比率(24小时收缩压与舒张压SD之比)。通过针对临床混杂因素和BP调整的Cox回归模型评估其与总死亡率和心血管死亡率(通过死亡证书获得)之间的关联。

与仍活着的患者相比,在随访期间死亡的患者的BP变异性值更高。在完全调整的模型中,白天、夜间和加权SD、收缩压和舒张压以及舒张压的平均实际变异性均与总死亡率和心血管死亡率显著相关。每增加1个SD的风险比对于总死亡率而言从1.05至1.09,对于心血管疾病死亡率而言从1.07至1.12。夜间收缩压SD≥12 mmHg与总的(风险比为1.13 [95%CI为1.06-1.21])和心血管死亡率(风险比为1.21 [95%CI为1.09-1.36])独立相关。

由此可见,高血压患者短期血压变异性与总死亡率和心血管死亡率独立相关。

原始出处:

Alejandro de la Sierra.et al.Prognostic Relevance of Short-Term Blood Pressure Variability The Spanish ABPM Registry.Hypertension.2020.https://www.ahajournals.org/doi/10.1161/HYPERTENSIONAHA.119.14508

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    2020-11-24 ms4000000901131801

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  5. 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  6. 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    2020-01-30 1478fa69m73暂无昵称

    学习了

    0

  7. 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  8. 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  10. 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    2020-01-29 一天没事干

    很好的学习机会

    0