Lung Cancer:阿法替尼联合贝伐珠单抗治疗EGFR突变NSCLC的Ⅰ期研究

2018-02-13 Wrangx 肿瘤资讯

一代EGFR TKIs吉非替尼或厄洛替尼联合贝伐珠单抗延长PFS时间。入组未经治疗EGFR突变NSCLC,首要研究终点安全性。

一代EGFR TKIs吉非替尼或厄洛替尼联合贝伐珠单抗延长PFS时间。入组未经治疗EGFR突变NSCLC,首要研究终点安全性。阿法替尼分为40 mg/天和30 mg/天两个剂量级,联合贝伐珠单抗15 mg/kg,每3周一次。根据剂量限制性毒性((DLT)选择剂量。纳入患者19例,40 mg剂量组5例,30 mg剂量组14例。5例40 mg/剂量组患者3例出现DLT,提示不可行。14例30 mg剂量组患者中3例出现DLT,均为3级非血液学毒性,可迅速解决。40 mg剂量组3级以上AEs分别为腹泻2例、皮疹1例、低氧血症1例、甲沟炎1例。30 mg剂量组3级以上AEs分别为腹泻2例、低氧血症1例。可评估患者16例,CR1例,PR12例,无一例出现疾病进展。结论为阿法替尼30 mg/天联合贝伐珠单抗耐受性可,疾病控制良好。联合使用是EGFR突变NSCLC潜在的治疗选择。

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    2018-02-15 liuyiping
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    2018-02-13 1ddf0692m34(暂无匿称)

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