J Food Drug Anal:鲫鱼卵中分离的唾液糖蛋白可促进骨质疏松小鼠的骨折愈合

2018-04-13 MedSci MedSci原创

在这项研究中,对卵巢切除诱导的骨质疏松症小鼠进行开放式胫骨骨折手术,以研究用鲫鱼卵(Ca-SGP)分离的唾液酸糖蛋白治疗骨折愈合的效果。动态组织学分析显示,术后5天Ca-SGP促进软骨愈伤组织的生成,然后在手术后第11天和第24天促进软骨组织转化为骨性组织,并在术后35天促进骨重建。此外,Ca-SGP在手术后第5天明显降低血清中TNF-α和IL-1β的分泌,从而抑制炎性反应。术后第11天,Ca-S

在这项研究中,对卵巢切除诱导的骨质疏松症小鼠进行开放式胫骨骨折手术,以研究用鲫鱼卵(Ca-SGP)分离的唾液酸糖蛋白治疗骨折愈合的效果。

动态组织学分析显示,术后5天Ca-SGP促进软骨愈伤组织的生成,然后在手术后第11天和第24天促进软骨组织转化为骨性组织,并在术后35天促进骨重建。此外,Ca-SGP在手术后第5天明显降低血清中TNF-α和IL-1β的分泌,从而抑制炎性反应。

术后第11天,Ca-SGP明显降低聚集蛋白聚糖的血清水平和mRNA的表达,增加VEGF和MMP13的分泌和表达,从而促进软骨基质的降解和血管长入。手术后第24天,Ca-SGP可明显增加成骨标志物Col1a和OCN的mRNA表达,并增加愈伤组织BV/TV和Tb.N,有助于编织骨的形成。术后第35天,Ca-SGP增强了编织骨向层状骨的转化,并改善了愈合组织的生物力学性质。

总之,Ca-SGP通过加速软骨内骨化促进骨质疏松小鼠的骨折愈合。

原始出处:

Wang F, Han L, et al., Sialoglycoprotein isolated from eggs of Carassius auratus promotes fracture healing in osteoporotic mice. J Food Drug Anal. 2018 Apr;26(2):716-724. doi: 10.1016/j.jfda.2017.07.017. Epub 2017 Sep 22.

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    2018-06-21 wangbingxhy
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createdName=ms6747015003810650, createdTime=Mon Apr 23 14:39:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689119, encodeId=263f1689119ee, content=<a href='/topic/show?id=b8ac10168e8b' target=_blank style='color:#2F92EE;'>#骨折愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101687, encryptionId=b8ac10168e8b, topicName=骨折愈合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4c28733108, createdName=HinsMax, createdTime=Wed Jan 09 11:39:00 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633469, encodeId=62a11633469bb, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, encryptionId=377824e1c0, topicName=ANA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=434d22047430, createdName=AspirantSuo, createdTime=Sat Mar 23 12:39:00 CST 2019, time=2019-03-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1700071, encodeId=b5841e00071c8, content=<a href='/topic/show?id=295524e541' target=_blank style='color:#2F92EE;'>#Anal#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2475, encryptionId=295524e541, topicName=Anal)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=de3a29999500, createdName=经常头晕, createdTime=Fri Jun 29 14:39:00 CST 2018, time=2018-06-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592446, encodeId=f47115924464c, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627242, encodeId=e852162e2429c, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305442, encodeId=ab1d3054423c, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2019-03-23 AspirantSuo
  5. [GetPortalCommentsPageByObjectIdResponse(id=1862307, encodeId=3595186230ee8, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Jun 21 14:39:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715581, encodeId=36171e1558187, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, createdName=ms6747015003810650, createdTime=Mon Apr 23 14:39:00 CST 2018, time=2018-04-23, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1689119, encodeId=263f1689119ee, content=<a href='/topic/show?id=b8ac10168e8b' target=_blank style='color:#2F92EE;'>#骨折愈合#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101687, encryptionId=b8ac10168e8b, topicName=骨折愈合)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ce4c28733108, createdName=HinsMax, createdTime=Wed Jan 09 11:39:00 CST 2019, time=2019-01-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1633469, encodeId=62a11633469bb, content=<a href='/topic/show?id=377824e1c0' target=_blank style='color:#2F92EE;'>#ANA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2471, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627242, encodeId=e852162e2429c, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305442, encodeId=ab1d3054423c, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-06-29 经常头晕
  6. [GetPortalCommentsPageByObjectIdResponse(id=1862307, encodeId=3595186230ee8, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Jun 21 14:39:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715581, encodeId=36171e1558187, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627242, encodeId=e852162e2429c, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305442, encodeId=ab1d3054423c, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-15 Eleven17
  7. [GetPortalCommentsPageByObjectIdResponse(id=1862307, encodeId=3595186230ee8, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Jun 21 14:39:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715581, encodeId=36171e1558187, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, 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channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1627242, encodeId=e852162e2429c, content=<a href='/topic/show?id=8ea0e6863a2' target=_blank style='color:#2F92EE;'>#糖蛋白#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=18, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76863, encryptionId=8ea0e6863a2, topicName=糖蛋白)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1d6621112920, createdName=chentianping, createdTime=Sun Apr 15 05:39:00 CST 2018, time=2018-04-15, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305442, encodeId=ab1d3054423c, content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=1862307, encodeId=3595186230ee8, content=<a href='/topic/show?id=1f0e626267' target=_blank style='color:#2F92EE;'>#Drug#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=6262, encryptionId=1f0e626267, topicName=Drug)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=baf586, createdName=wangbingxhy, createdTime=Thu Jun 21 14:39:00 CST 2018, time=2018-06-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1715581, encodeId=36171e1558187, content=<a href='/topic/show?id=a217e58972' target=_blank style='color:#2F92EE;'>#food#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7589, encryptionId=a217e58972, topicName=food)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=68d031960225, 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content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 changjiu

    学习一下谢谢

    0

  9. 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GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 1226270em93暂无昵称

    讲的很棒啊!以后继续关注

    0

  10. 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content=学习一下谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLGSUSR8zwnWWLT4FMl5XH8S58HuZslVkLsAPbXDXaliagK7TOxQfmngKibG1yrDonepCLDkcxGk8hS/0, createdBy=b8282062892, createdName=changjiu, createdTime=Fri Apr 13 17:47:11 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305422, encodeId=2d8830542205, content=讲的很棒啊!以后继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:25 CST 2018, time=2018-04-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=305421, encodeId=42e630542152, content=继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/04/13/dfb1368a90ffeba98ac5dd08c9b962ae.jpg, createdBy=381d2327523, createdName=1226270em93暂无昵称, createdTime=Fri Apr 13 15:48:04 CST 2018, time=2018-04-13, status=1, ipAttribution=)]
    2018-04-13 1226270em93暂无昵称

    继续关注

    0