JAHA:传统心血管危险因素及其与心脏瓣膜病或升主动脉疾病手术之间相关性分析!

2017-05-07 xing.T MedSci原创

该研究是第一个真正的旨在调查传统的心血管危险因素及其与心脏瓣膜疾病和升主动脉疾病之间相关性的前瞻性研究。研究人员证实了传统的危险因素和主动脉瓣狭窄之间的很强的相关性,但只在伴有冠心病的患者中。在孤立性心脏瓣膜病患者中,传统危险因素的影响是有所不同的。

心脏瓣膜和升主动脉疾病的危险因素主要是基于回顾性数据。为了通过前瞻性研究来阐明这些因素,近日,心血管疾病领域权威杂志JAHA上发表了一篇研究文章。研究人员采用来自于大型的、人群为基础的调查数据进行了一项嵌套病例对照研究。

共有777例接受了心脏瓣膜疾病或升主动脉疾病的患者参与了瑞典北部的人群为基础的健康调查。从调查到手术的时间中位数(四分位距)为10.5(9)年。手术的主要指征包括主动脉瓣狭窄(41%)、主动脉瓣关闭不全(12%)、二尖瓣关闭不全(23%)和升主动脉扩张/夹层(17%)。对于每一个病例,研究人员分配了年龄、性别和地理区域相匹配的对照者。

在多变量模型中,研究人员发现高血压、高胆固醇水平、糖尿病和主动吸烟是主动脉瓣狭窄手术的预测因素。手术治疗主动脉瓣关闭不全与低胆固醇水平相关,而高胆固醇水平可以预测二尖瓣关闭不全手术。高血压和以往吸烟可以预测升主动脉疾病的手术,而糖尿病与风险降低相关。在排除冠状动脉粥样硬化病例后,研究人员发现只有胆固醇与主动脉瓣关闭不全之间以及糖尿病和升主动脉疾病之间的负相关性仍然存在。

该研究是第一个真正的旨在调查传统的心血管危险因素及其与心脏瓣膜疾病和升主动脉疾病之间相关性的前瞻性研究。研究人员证实了传统的危险因素和主动脉瓣狭窄之间的很强的相关性,但只在伴有冠心病的患者中。在孤立性心脏瓣膜病患者中,传统危险因素的影响是有所不同的。

原始出处:


Johan Ljungberg,et al. Traditional Cardiovascular Risk Factors and Their Relation to Future Surgery for Valvular Heart Disease or Ascending Aortic Disease: A Case–Referent Study.JAHA.2017. http://jaha.ahajournals.org/content/6/5/e005133

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  5. 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  6. 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  7. 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