BMJ:哪些假期更易发生急性心梗?

2019-01-11 王淳 环球医学

2018年12月,瑞典学者发表在《BMJ》的SWEDEHEART观察性研究1998~2013,考察了圣诞节、法定假日、体育赛事和时间因素作为急性心肌梗死(MI)诱因的作用。

2018年12月,瑞典学者发表在《BMJ》的SWEDEHEART观察性研究1998~2013,考察了圣诞节、法定假日、体育赛事和时间因素作为急性心肌梗死(MI)诱因的作用。

目的:旨在研究昼夜节律、法定假日和主要体育赛事是否是心肌梗死的诱因。

设计:使用SWEDEHEART全国冠心病护理单元注册进行的回顾性观察性研究。

地点:瑞典。

参与者:1998~2013年283014例报告给SWEDEHEART的心梗病例。所有病例记录包括症状发作日期,并且88%的时间精确到一分钟左右。

干预:鉴别出在圣诞节/新年、复活节和仲夏假期,以及世界杯、UEFA欧洲锦标赛、夏季和冬季奥运会期间症状发作的心梗。假期前和假期后两周设为对照阶段,对于体育赛事,对照阶段设为赛事的前一年和后一年的相同时间。昼夜和周分析将周日和24:00设置为参考天和参考小时,与所有其他天和小时进行了比较。使用计数回归模型计算发病率比。

主要结局测量指标:每天发生心梗的数量。

结果:圣诞节和仲夏假期与较高的心梗风险相关(分别为:发病率比1.15;95% 置信区间[CI],1.12~1.19;P<0.001;1.12;1.07~1.18;P<0.001)。最高的相关风险发生在平安夜(1.37;1.29~1.46;P<0.001)。复活节或体育赛事期间未观察到风险增加。心梗风险具有昼夜和周差异,在清早和星期一的风险较高。在75岁以上和具有糖尿病和冠心病史的患者中,这些结果更显着。

结论:在这项覆盖了16年心梗住院并且记录的症状发作时间接近一分钟的全国真实世界研究中,圣诞节和仲夏假期与较高的心梗风险相关,尤其在老年和有病患者中,提示了外部因素在脆弱个体中的作用。

原始出处:

Mohammad MA, Karlsson S, Haddad J, et al. Christmas, national holidays, sport events, and time factors as triggers of acute myocardial infarction: SWEDEHEART observational study 1998-2013. BMJ. 2018 Dec 12;363:k4811. doi: 10.1136/bmj.k4811.

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    2019-10-14 gaoxiaoe
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    2019-01-17 flysky120

    学习急性心肌梗塞的知识了

    0

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