Cell Res:中国科学家发现发热伴血小板减少综合征治疗途径

2019-10-14 谭元斌 新华网

攻克致死率极高的发热伴血小板减少综合征取得重大进展,我国科研人员发现治疗发热伴血小板减少综合征的有效途径。

攻克致死率极高的发热伴血小板减少综合征取得重大进展,我国科研人员发现治疗发热伴血小板减少综合征的有效途径。

近期,中国科学院武汉病毒研究所(生物安全大科学研究中心)彭珂研究组与肖庚富研究组联合中国军事医学科学院刘玮研究团队联合攻关,发现钙离子通道抑制剂贝尼地平等能够在细胞水平显著抑制发热伴血小板减少综合征病毒的入侵及病毒基因组的复制。

该联合团队对发热伴血小板减少综合征病人的临床大数据开展了回溯性研究,首次揭示了硝苯地平可以抑制患者体内发热伴血小板减少综合征病毒的复制,病毒感染引起的病死率由19.7%降至3.6%。

据肖庚富介绍,发热伴血小板减少综合征是近年来在我国新发,并流行于韩国、日本等东亚地区的病毒性传染疾病。它由一种蜱传新型布尼亚病毒,即发热伴血小板减少综合征病毒感染所引起。目前,尚无针对该病毒的预防性疫苗和特异性抗病毒药物。

由于发热伴血小板减少综合征起病急,临床病死率高达12%至50%,且发病率呈现逐年上升的趋势,其2017年被世界卫生组织列入急需研究的重点疾病清单,特异性抗病毒药物的研发成为亟待解决的科学问题。

彭珂说,他们的研究为发热伴血小板减少综合征抗病毒药物研发提供了重要的理论参考,也提示钙离子通道抑制剂类药物可能具有较为广泛的抗病毒效应。目前,相关研究成果已在线发表于国际学术期刊《细胞研究》。

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    2020-07-03 维他命
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