Gastroenterology:TP53是巴雷特食管患者高级别进展的重要预测因素

2018-04-03 zhangfan MedSci原创

研究发现,TP53突变是巴雷特食管患者是否出现疾病进展的重要因素,该突变在异型增生或拷贝数发生实质性变化前就可以发现

巴雷特食管(BE)是食管腺癌的最大危险因素,但仅有一小部分BE患者发展为肿瘤。生物标志物是识别进展高风险患者最有效的方法。近日研究人员就BE进展以及未进展患者活检基因组差异进行了研究。

研究招募了24名BE进展患者,其中包含高度分化不良患者 (HGD, n=14)和食管腺癌患者(EAC, n=10),同时招募了73名未进展BE患者作为对照组,对照组患者至少5年全内镜活检监测确证无HGD或EAC进展。采集患者组织样本进行致病突变、基因拷贝数和细胞倍性比较。

进展患者中TP53突变率为46%,而对照组患者仅为5%。在样本分析中,BE组织TP53突变导致患者进展风险增加13.8倍(95% CI, 3.2-61.0)。组间基因拷贝数和细胞倍性无显著差异。研究人员在57个不同基因中发现147个致病突变,进展期患者的平均致病突变数高于对照组(2.5vs1.2)。TP 53和其他体细胞突变在拷贝数变化有限的非整倍体样本中被反复检出。

研究发现,TP53突变是巴雷特食管患者是否出现疾病进展的重要因素,该突变在异型增生或拷贝数发生实质性变化前就可以发现。

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    2018-08-17 zhouqu_8
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    2018-12-01 许安
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  5. 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style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 05 01:36:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302818, encodeId=f893302818ae, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Apr 05 00:07:57 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
  6. 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style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 05 01:36:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302818, encodeId=f893302818ae, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Apr 05 00:07:57 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 zhishijing
  7. 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01:36:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1372395, encodeId=528413e239518, content=<a href='/topic/show?id=9d861362e53' target=_blank style='color:#2F92EE;'>#p53#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=13627, encryptionId=9d861362e53, topicName=p53)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5d70341, createdName=zhishijing, createdTime=Thu Apr 05 01:36:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1437315, encodeId=5af2143e3159f, content=<a href='/topic/show?id=0e311010591a' target=_blank style='color:#2F92EE;'>#食管#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101059, encryptionId=0e311010591a, topicName=食管)], attachment=null, 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style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Thu Apr 05 01:36:00 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302818, encodeId=f893302818ae, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://cdnapi.center.medsci.cn/medsci/head/2018/01/15/8213228fe923915543544ad3da7e1c64.jpg, createdBy=6bd82014262, createdName=秀红, createdTime=Thu Apr 05 00:07:57 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 zhouqu_8
  8. 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    2018-04-05 zblhy
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