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Radiology：移植肾功能如何？做个高级超声看看！

2018-05-18 shaosai MedSci原创

移植肾肾功能不良横波弹性超声
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本研究旨在评价横波弹性超声是否有助于鉴别稳定性移植肾功能与急性移植肾功能不良及慢性移植肾功能不良，评价横波弹性超声测量指数与阻力指数（RI）、血清肌酐水平、肾小球滤过率估计值(eGFR)和活检结果的相关性，并将结果发表在Radiology上。

本研究旨在评价横波弹性超声是否有助于鉴别稳定性移植肾功能与急性移植肾功能不良及慢性移植肾功能不良，评价横波弹性超声测量指数与阻力指数（RI）、血清肌酐水平、肾小球滤过率估计值(eGFR)和活检结果的相关性，并将结果发表在Radiology上。

本研究共纳入了60例行肾移植的患者。患者根据移植肾功能情况分为肾功能稳定移植肾、急性移植肾功能不良或慢性移植肾功能不良。比较平均肾实质硬化程度。利用ROC曲线评价鉴别可能性。

结果为，共有30例患者出现移植肾功能不良（急性19例、慢性11例）。在肾功能稳定移植肾、急性移植肾功能不良和慢性移植肾功能不良的平均肾实质硬化值分别为8.51 kPa ± 2.44、11.06 kPa ± 2.91和24.50 kPa ± 4.49（稳定和急性肾功能不良P = .010；稳定和慢性肾功能不良P < .001；急性肾功能不良和慢性肾功能不良P < .001）。Banff I级（轻度肾间质纤维化和肾小管萎缩）

的移植肾实质硬化值与Banff II级（中度肾间质纤维化和肾小管萎缩）的具有显着性差异(P = .02)。肾实质硬化与eGFR (r = -0.725； P < .001)具有负性相关，而与RI (r = 0.562； P < .001)和血清肌酐值(r = 0.714； P < .001)具有正性相关。鉴别稳定肾功能移植肾和急性肾功能不良移植肾的敏感性和特异性分别为73.68% 、80% (阈值为10.11 kPa)。

本研究表明，利用横波弹性超声评价肾实质硬化程度有助于鉴别肾功能稳定移植肾与急性和慢性肾功能不良移植肾。肾实质硬化与eGFR具有负性相关，而与RI和血清肌酐值具有正性相关表明横波弹性超声可能会反应移植肾的肾功能状态。

原始出处：

Ghonge NP， Mohan M， Kashyap V. et al.Renal Allograft Dysfunction： Evaluation with Shear-wave Sonoelastography.Radiology.DOI：10.1148/radiol.2018170577

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  1. [GetPortalCommentsPageByObjectIdResponse(id=1850672, encodeId=679518506e2bb, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Jul 18 03:21:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316538, encodeId=a1403165388d, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sat May 19 07:29:39 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316446, encodeId=6b02316446ae, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat May 19 00:12:20 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316435, encodeId=f61231643542, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:35:11 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-07-18 yese

    #肾功能#

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=1850672, encodeId=679518506e2bb, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Jul 18 03:21:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316538, encodeId=a1403165388d, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sat May 19 07:29:39 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316446, encodeId=6b02316446ae, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat May 19 00:12:20 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316435, encodeId=f61231643542, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:35:11 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-19 张新亮1853311252142e2fm

    好文献学习了

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=1850672, encodeId=679518506e2bb, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Jul 18 03:21:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316538, encodeId=a1403165388d, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sat May 19 07:29:39 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316446, encodeId=6b02316446ae, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat May 19 00:12:20 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316435, encodeId=f61231643542, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:35:11 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-19 飛歌

    学习了很有用

    0

  4. [GetPortalCommentsPageByObjectIdResponse(id=1850672, encodeId=679518506e2bb, content=<a href='/topic/show?id=46c682469e4' target=_blank style='color:#2F92EE;'>#肾功能#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=82469, encryptionId=46c682469e4, topicName=肾功能)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Wed Jul 18 03:21:00 CST 2018, time=2018-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316538, encodeId=a1403165388d, content=好文献学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b5a62240667, createdName=张新亮1853311252142e2fm, createdTime=Sat May 19 07:29:39 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316446, encodeId=6b02316446ae, content=学习了很有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/oLAjfB7s1ib3IzoRn621JdKCFUI4XvNELcibocrAVU6aUzEVDSaf3rYH08PUYUiagGqxAEhj8g9WqqNvD1CupIpCrmnR2OrqHZh/0, createdBy=7f181365728, createdName=飛歌, createdTime=Sat May 19 00:12:20 CST 2018, time=2018-05-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=316435, encodeId=f61231643542, content=谢谢分享学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/Q3auHgzwzM4o2XVpJ6449yqDsjibydI5HnJ8MibGxNn4HZiaZib0bdfibbwoz3KQrIyN9AGxq36ZlZRNicYlPfOOWMtwgsajY6mGNFiaPclFdowjD0/0, createdBy=97bd1338592, createdName=清风拂面, createdTime=Fri May 18 23:35:11 CST 2018, time=2018-05-18, status=1, ipAttribution=)]
    2018-05-18 清风拂面

    谢谢分享学习

    0