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精准医疗的突破：FoundationOne CDx癌症基因组谱可用于Rozlytrek治疗ROS1阳性肺癌的伴随诊断

2019-12-27 Allan MedSci原创

ROS1阳性肺癌FoundationOneCDx癌症基因组谱Rozlytrek
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日本Chugai制药株式会社近日宣布，日本厚生劳动省已批准FoundationOne CDx癌症基因组谱用于酪氨酸激酶抑制剂Rozlytrek治疗ROS1阳性、局部晚期或转移性非小细胞肺癌（NSCLC）的伴随诊断。该批准使医生能够确定哪些NSCLC患者可以通过检测ROS1融合基因从Rozlytrek治疗中获益。

日本Chugai制药株式会社近日宣布，日本厚生劳动省已批准FoundationOne CDx癌症基因组谱用于酪氨酸激酶抑制剂Rozlytrek治疗ROS1阳性、局部晚期或转移性非小细胞肺癌（NSCLC）的伴随诊断。该批准使医生能够确定哪些NSCLC患者可以通过检测ROS1融合基因从Rozlytrek治疗中获益。

Chugai制药副总裁Minoru Watanabe博士说：“我们很高兴FoundationOne CDx癌症基因组图谱现在被批准作为针对ROS1融合基因的伴随诊断。ROS1融合基因是NSCLC中的驱动突变之一，尽管NSCLC中ROS1融合基因的频率仅为1％-2％，但是使用ROS1抑制剂的治疗可能成为ROS1阳性癌症患者的重要治疗选择”。


原始出处：

http://www.firstwordpharma.com/node/1690055#axzz69CnI0iLA

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    2020-08-06 qjddjq

    #CDx癌症基因组谱#

    0

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    2020-05-02 ms24272190615788285182

    #癌症基因#

    0

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    2020-02-27 一叶知秋

    #ROS1阳性#

    0

  4. 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time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403478, encodeId=b5dd14034e87d, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533962, encodeId=28141533962bb, content=<a href='/topic/show?id=0717156309a' target=_blank style='color:#2F92EE;'>#ROS1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15630, encryptionId=0717156309a, topicName=ROS1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573339, encodeId=2ce315e3339e8, content=<a href='/topic/show?id=6bbc15655cc' target=_blank style='color:#2F92EE;'>#Rozlytrek#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15655, encryptionId=6bbc15655cc, topicName=Rozlytrek)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b70f15850841, createdName=lanyan20020091, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581065, encodeId=e6ff158106568, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2020-07-04 ms2186806800017884

    #伴随诊断#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1782770, encodeId=23151e8277032, content=<a href='/topic/show?id=8efd44281d' target=_blank style='color:#2F92EE;'>#CDx癌症基因组谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4428, encryptionId=8efd44281d, topicName=CDx癌症基因组谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Thu Aug 06 01:05:00 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067007, encodeId=bb98206e00770, content=<a href='/topic/show?id=2ec9e133569' target=_blank style='color:#2F92EE;'>#癌症基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71335, encryptionId=2ec9e133569, topicName=癌症基因)], attachment=null, authenticateStatus=null, 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time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403478, encodeId=b5dd14034e87d, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533962, encodeId=28141533962bb, content=<a href='/topic/show?id=0717156309a' target=_blank style='color:#2F92EE;'>#ROS1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15630, encryptionId=0717156309a, topicName=ROS1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573339, encodeId=2ce315e3339e8, content=<a href='/topic/show?id=6bbc15655cc' target=_blank style='color:#2F92EE;'>#Rozlytrek#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15655, encryptionId=6bbc15655cc, topicName=Rozlytrek)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b70f15850841, createdName=lanyan20020091, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581065, encodeId=e6ff158106568, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 lsndxfj

    #ROS#

    0

  6. 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channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26104, encryptionId=326f2610414, topicName=伴随诊断)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sat Jul 04 18:05:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364556, encodeId=366b136455601, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403478, encodeId=b5dd14034e87d, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533962, encodeId=28141533962bb, content=<a href='/topic/show?id=0717156309a' target=_blank style='color:#2F92EE;'>#ROS1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15630, encryptionId=0717156309a, topicName=ROS1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573339, encodeId=2ce315e3339e8, content=<a href='/topic/show?id=6bbc15655cc' target=_blank style='color:#2F92EE;'>#Rozlytrek#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15655, encryptionId=6bbc15655cc, topicName=Rozlytrek)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b70f15850841, createdName=lanyan20020091, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581065, encodeId=e6ff158106568, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 shijzhiewnjhch

    #精准#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1782770, encodeId=23151e8277032, content=<a href='/topic/show?id=8efd44281d' target=_blank style='color:#2F92EE;'>#CDx癌症基因组谱#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=4428, encryptionId=8efd44281d, topicName=CDx癌症基因组谱)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c49e75, createdName=qjddjq, createdTime=Thu Aug 06 01:05:00 CST 2020, time=2020-08-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2067007, encodeId=bb98206e00770, content=<a href='/topic/show?id=2ec9e133569' target=_blank style='color:#2F92EE;'>#癌症基因#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=39, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71335, encryptionId=2ec9e133569, topicName=癌症基因)], attachment=null, authenticateStatus=null, 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channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=26104, encryptionId=326f2610414, topicName=伴随诊断)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/fa8I6JticHgohY5FSGE98I1F4gpCjrpl2nbN6jZJY6JEqAjUibjItOA9AsgbBwTuBzAPbU5Tl8DxfemWUFFzBOYw/132, createdBy=24c12500054, createdName=ms2186806800017884, createdTime=Sat Jul 04 18:05:00 CST 2020, time=2020-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1364556, encodeId=366b136455601, content=<a href='/topic/show?id=7c5615628ad' target=_blank style='color:#2F92EE;'>#ROS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15628, encryptionId=7c5615628ad, topicName=ROS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=acc3210, createdName=lsndxfj, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403478, encodeId=b5dd14034e87d, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533962, encodeId=28141533962bb, content=<a href='/topic/show?id=0717156309a' target=_blank style='color:#2F92EE;'>#ROS1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15630, encryptionId=0717156309a, topicName=ROS1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573339, encodeId=2ce315e3339e8, content=<a href='/topic/show?id=6bbc15655cc' target=_blank style='color:#2F92EE;'>#Rozlytrek#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15655, encryptionId=6bbc15655cc, topicName=Rozlytrek)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b70f15850841, createdName=lanyan20020091, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581065, encodeId=e6ff158106568, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 智者为医08

    #ROS1#

    0

  8. 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time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1403478, encodeId=b5dd14034e87d, content=<a href='/topic/show?id=ebbde6353be' target=_blank style='color:#2F92EE;'>#精准#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76353, encryptionId=ebbde6353be, topicName=精准)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83epQX9hfEIBiaPg0e9KvLYVBCSGYydH6K6OQxBh3RaOC0TYP9HYy2v0XdHib1LFnZNU5Siak0P8oh8Aqw/132, createdBy=acd92440184, createdName=shijzhiewnjhch, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1533962, encodeId=28141533962bb, content=<a href='/topic/show?id=0717156309a' target=_blank style='color:#2F92EE;'>#ROS1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=46, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15630, encryptionId=0717156309a, topicName=ROS1)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4dfa37, createdName=智者为医08, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1573339, encodeId=2ce315e3339e8, content=<a href='/topic/show?id=6bbc15655cc' target=_blank style='color:#2F92EE;'>#Rozlytrek#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15655, encryptionId=6bbc15655cc, topicName=Rozlytrek)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=b70f15850841, createdName=lanyan20020091, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1581065, encodeId=e6ff158106568, content=<a href='/topic/show?id=3beb12600e5' target=_blank style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 lanyan20020091

    #Rozlytrek#

    0

  9. 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style='color:#2F92EE;'>#NDA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=12600, encryptionId=3beb12600e5, topicName=NDA)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9a9e16702381, createdName=12498a49m65暂无昵称, createdTime=Sun Dec 29 07:05:00 CST 2019, time=2019-12-29, status=1, ipAttribution=)]
    2019-12-29 12498a49m65暂无昵称

    #NDA#

    0

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