Gastroenterology:健康的生活方式与较低的结直肠癌风险有关

2018-12-09 MedSci MedSci原创

健康生活方式对结直肠癌(CRC)发生风险的影响尚不清楚。因此,研究人员旨在开发健康的生活方式评分,以评估健康生活方式是否可以降低CRC发生的风险。

背景与目的
健康生活方式对直肠癌(CRC)发生风险的影响尚不清楚。因此,研究人员旨在开发健康的生活方式评分,以评估健康生活方式是否可以降低CRC发生的风险。

方法
研究人员从德国健康数据库中收集所需数据,并使用多元逻辑回归分析来检验健康生活方式评分与CRC发生风险的关联(5种生活方式因素:吸烟,饮酒,饮食,身体活动和身体肥胖) )。同时研究人员基于53种风险变异创建了遗传风险评分,并根据遗传风险进行研究分层,减少研究误差。

结果
在本项研究中,研究人员调查了4092名CRC患者和3032名没有CRC的患者(对照组)。在调整后的模型中,与只拥有0或1个健康生活方式因素的参与者相比,拥有2个健康生活方式因素的参与者CRC发生率降低([OR] 0.85; 95%[CI] 0.67-1.06),3个健康生活方式因素的参与者(OR 0.62; 95%CI 0.50-0.77) ,4个(OR 0.53; 95%CI 0.42-0.66)或5(OR 0.33; 95%CI 0.26-0.43)健康生活方式因素使CRC的风险越来越低(P<.0001)。我们发现亚组之间没有差异,这些亚组根据遗传风险评分,结肠镜检查史或CRC家族史进行分层。总体而言,45%的CRC的发病(95%CI :34%-53%)可归因于所有5种健康生活方式行为的破坏。

结论
在这项基于人群的大型病例对照研究中,健康生活方式因素似乎可以降低CRC发生的风险,这些结果强调了初级预防CRC的重要性。

原始出处:

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    2019-11-02 sjq027
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    2019-06-06 许安
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    2018-12-09 王秀

    学习了,涨知识了!

    0