西兰花提取物或能治疗癌症

2015-12-03 佚名 生物谷

图片来自:http://www.futurity.org/ 存在于西兰花嫩芽的一种化合物不仅有助于预防癌症,而且还有希望治愈癌症。这种化合物叫做萝卜硫素(Sulforaphane),并广泛存在于蔬菜中,如甘蓝、花椰菜、卷心菜,特别是高浓度的西兰花嫩芽中。萝卜硫素还可以作为治疗退行性神经疾病(BSE)的膳食补充剂。美国德州农工健康科学中心研究所的科学家,以及美国俄勒冈州的研究者,此前就曾发现,

图片来自:http://www.futurity.org/

存在于西兰花嫩芽的一种化合物不仅有助于预防癌症,而且还有希望治愈癌症。这种化合物叫做萝卜硫素(Sulforaphane),并广泛存在于蔬菜中,如甘蓝、花椰菜、卷心菜,特别是高浓度的西兰花嫩芽中。萝卜硫素还可以作为治疗退行性神经疾病(BSE)的膳食补充剂。美国德州农工健康科学中心研究所的科学家,以及美国俄勒冈州的研究者,此前就曾发现,在实验室的体外细胞试验中,萝卜硫素能抑制结肠癌和前列腺癌的细胞。他们现在已经表明,这种化合物在人体也有类似的效果。

在一项临床研究中,28位50岁以上的志愿者,正在接受常规结肠镜检查。研究人员还进行了他们的十字花科蔬菜的饮食习惯的调查。他们的结肠活检发现,那些经常吃西兰花的志愿者的肿瘤抑制基因p16基因的表达水平较高,而那些很少或根本没有吃十字花科蔬菜的志愿者则该基因的表达水平很低。

然而似乎很奇怪的是,萝卜硫素在体内的存留时间很短,在不到24小时在体内就检测不到了萝卜硫素。这可能暗示了,由萝卜硫素及其代谢物触发了某些表观遗传学的修饰,使得即使萝卜硫素存留时间短,下游的机制或者途径仍然可以持续,至少在短期内仍然对细胞存在影响。”换句话说,食用含有萝卜硫素的食物可以“改变”你的基因,并帮助你的身体对抗肿瘤生长。

但是,这并不全是好消息。在动物模型中,萝卜硫素被证明通常抑制结肠癌的发展,但它其实是一把双刃剑。萝卜硫素可以诱导名为Nrf2的蛋白质表达,它具有抗氧化的解毒作用,而且显然是有利于抗癌。但是,在癌症的发展后期,Nrf2还有可以促进肿瘤生长的作用,甚至可以增强癌细胞斑块在动脉的堆积。因此科学家认为Nrf2是值得进一步探讨的,不只是对癌症治疗,也在于该蛋白可能存在着调节心血管疾病的作用。

推荐原文阅读:

CAN A BROCCOLI SPROUT PILL FIGHT CANCER?

Praveen Rajendran, Wan-Mohaiza Dashwood et al,Nrf2 status affects tumor growth, HDAC3 gene promoter associations, and the response to sulforaphane in the colon.clinic epigenetics .2015 

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    2015-12-27 hixiaoluo

    好文章,值得收藏

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    2015-12-27 hixiaoluo

    好文章,值得收藏

    0

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    2015-12-16 三三五五

    双刃剑!

    0

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    2015-12-04 老段

    西兰花在抗癌变的主要食物

    0

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