SCI REP:吸烟、阻塞性睡眠呼吸暂停综合征及其对代谢的联合效应!

2017-08-18 xing.T MedSci原创

由此可见,吸烟和OSAS对代谢紊乱参数具有协同作用。戒烟可能对阻塞性睡眠呼吸暂停综合征患者胰岛素抵抗和脂代谢的影响不大。

代谢紊乱分别与阻塞性睡眠呼吸暂停综合征(OSAS)和吸烟有关。然而,没有研究评估它们与代谢参数的相互作用,包括胰岛素抵抗和血脂异常。近日,Scientific reports 杂志上发表了一篇研究文章,在该研究旨在调查OSAS和吸烟联合是否会导致额外的代谢紊乱。

研究人员在2014年-2015年期间招募了成年男性。抽取可空腹血液样本以测定血糖、胰岛素和血脂水平。同时,参与者完成了包括吸烟包每年的暴露条目在内的问卷、埃普沃思嗜睡量表和整夜多导睡眠图检查。

研究人员发现吸烟者的血糖、胰岛素、总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)水平较高,但高密度脂蛋白胆固醇(HDL-C)水平较非吸烟者低。此外,在未经调整后,胰岛素抵抗的风险随着OSAS严重程度的增加而增加。对潜在的混杂因素进行调整后,研究人员发现阻塞性睡眠呼吸暂停综合征与吸烟对胰岛素抵抗具有相互作用(P=0.025)。尽管这种差异并不显著,戒烟对患阻塞性睡眠呼吸暂停综合征的吸烟者似乎好处不明显。

由此可见,吸烟和OSAS对代谢紊乱参数具有协同作用。戒烟可能对阻塞性睡眠呼吸暂停综合征患者胰岛素抵抗和脂代谢的影响不大。

原始出处:

Huaming Zhu,et al. Smoking, obstructive sleep apnea syndrome and their combined effects on metabolic parameters: Evidence from a large cross-sectional study.Scientific reports. 2017. https://www.nature.com/articles/s41598-017-08930-x

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    2018-07-08 tomyang96
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  5. 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  6. 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    2017-08-20 yfjms

    学习了

    0

  7. 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channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 19 11:27:33 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235047, encodeId=9d2123504ee4, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Aug 19 09:55:37 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235026, encodeId=940523502622, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:24:57 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-20 大爰

    学习了谢谢分享!!

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1989056, encodeId=8aa319890567c, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jan 13 08:56:00 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696754, encodeId=57781696e5434, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, 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encodeId=0c9c2352e06e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Aug 20 06:52:32 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235230, encodeId=e83623523033, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Aug 20 06:19:21 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235080, encodeId=900f235080aa, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 19 11:27:33 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235047, encodeId=9d2123504ee4, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Aug 19 09:55:37 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235026, encodeId=940523502622, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:24:57 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 海之蓝

    谢谢

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1989056, encodeId=8aa319890567c, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jan 13 08:56:00 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696754, encodeId=57781696e5434, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, 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encodeId=0c9c2352e06e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Aug 20 06:52:32 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235230, encodeId=e83623523033, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Aug 20 06:19:21 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235080, encodeId=900f235080aa, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 19 11:27:33 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235047, encodeId=9d2123504ee4, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Aug 19 09:55:37 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235026, encodeId=940523502622, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:24:57 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 186****0580(小山羊)

    学习了谢谢了

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1989056, encodeId=8aa319890567c, content=<a href='/topic/show?id=246ee29858f' target=_blank style='color:#2F92EE;'>#睡眠呼吸#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72985, encryptionId=246ee29858f, topicName=睡眠呼吸)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3138208, createdName=zhanfl, createdTime=Sat Jan 13 08:56:00 CST 2018, time=2018-01-13, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1696754, encodeId=57781696e5434, content=<a href='/topic/show?id=d2e99e651e4' target=_blank style='color:#2F92EE;'>#阻塞#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=97651, encryptionId=d2e99e651e4, topicName=阻塞)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=a23129903429, 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encodeId=0c9c2352e06e, content=学习了, beContent=null, objectType=article, channel=null, level=null, likeNumber=53, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Sun Aug 20 06:52:32 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235230, encodeId=e83623523033, content=学习了谢谢分享!!, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200816/e4675a86ea694f12b82202b320dc2654/12f6b900498349e994ce8f516a584d6a.jpg, createdBy=09431951290, createdName=大爰, createdTime=Sun Aug 20 06:19:21 CST 2017, time=2017-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235080, encodeId=900f235080aa, content=谢谢, beContent=null, objectType=article, channel=null, level=null, likeNumber=55, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJpBl6xwMmnsKibwxcAIltOH3nnCEQbNE6TDbYtCKe8hYI0oJrbduNqnJraM1PyyjPKU1suAzicYPaA/132, createdBy=eeaf2031798, createdName=海之蓝, createdTime=Sat Aug 19 11:27:33 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235047, encodeId=9d2123504ee4, content=学习了谢谢了, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3zSn0GqHrsfLPeNmuNF9ibgMfMOAs7Iic5MpiaU8RLmRH67xCKuk5wzfhb7G4ib7ia6z9lrnsTicj1nAUfEOMecZDtvvu/0, createdBy=d7f91939785, createdName=186****0580(小山羊), createdTime=Sat Aug 19 09:55:37 CST 2017, time=2017-08-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=235026, encodeId=940523502622, content=学习了谢谢分享, beContent=null, objectType=article, channel=null, level=null, likeNumber=0, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Sat Aug 19 09:24:57 CST 2017, time=2017-08-19, status=1, ipAttribution=)]
    2017-08-19 130****4638

    学习了谢谢分享

    0

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广州总医院研究称,青年男性吸烟发生心梗危险增6倍

军区广州总医院向定成等发表研究称,吸烟是ST段抬高急性心肌梗死(STEMI)的主要危险因素,但其相对致病风险度存在年龄和性别差异,吸烟对青年男性的相对致病风险最高且是最主要的致病因素。

J Periodontal Res:吸烟对牙周治疗后炎症,龈沟液中骨重塑标记物和龈下微生物的影响

牙周通过抑制微生物介导的局部炎性宿主反应维持健康。吸烟可能会影响这一过程。本研究比较了慢性牙周炎患者治疗期和支持性牙周治疗后,重度吸烟者和非吸烟者的骨改建标志物和龈沟液含量。

J Periodontal Res:患牙周炎吸烟者的临床参数与宿主反应之间的相互作用

牙周疾病是导致牙齿缺失的主要公共健康问题,也被证明与几种慢性全身性疾病有关。吸烟是许多系统性疾病以及牙周炎发展的主要危险因素。虽然吸烟者发展成牙周炎导致牙齿缺失的风险明显增加,但是与吸烟有关的疾病的易感性也不同。这项调查的重点是确定四个广泛变量的差异,包括:(i)宿主反应分子; (二)牙周临床参数; (iii)对牙周病原体和口腔共生细菌的抗体应答;和(iv)在有(n = 171)和无(n = 11

J Natl Cancer I:为了不得食管癌,别抽烟了

食管癌因较差的预后,严重影响着生命健康。研究显示,吸烟是其主要风险因素之一。那么,戒烟会降低食管癌患病风险吗?是否戒烟时间越长,风险越低?瑞典卡罗林斯卡医学院分子医学与外科学系Shao-Hua Xie博士,对戒烟与食管癌两种主要组织学类型之间的相关性、戒烟时间的影响、不同种族的影响进行了系统回顾和Meta分析,相关成果在线发表于8月3日的《JNCI》上。

J Periodontol:白藜芦醇对于香烟烟雾吸入介导的大鼠牙周炎骨吸收的抑制作用

用以调节宿主对牙周病反应的替代疗法已经在研究。了解治疗牙周炎的新方法对于患牙周炎高风险者尤为重要,如吸烟者。本研究的目的是调查白藜芦醇(RESV)对香烟吸入(CSI)对实验性牙周炎(EP)的影响。