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ACS Appl Mater Interfaces：纳米纤维通过FAK/RhoA/YAP1通路调节单个骨髓干细胞成骨

2018-09-07 MedSci MedSci原创

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了解细胞-材料相互作用是开发用于组织再生的生物激发材料的先决条件。虽然纳米纤维生物材料已广泛用于组织再生，但纳米纤维结构对干细胞行为的影响在很大程度上是未知的，因为用于纳米纤维-细胞相互作用的生物材料系统不能排除细胞-细胞相互作用的干扰。 在这项研究中，我们开发了一种独特的微图案技术，将一个单一干细胞限制在纳米纤维微图案基质的微区内，因此可消除任何潜在的细胞间通信。纳米纤维微图案基质模拟了天

了解细胞-材料相互作用是开发用于组织再生的生物激发材料的先决条件。虽然纳米纤维生物材料已广泛用于组织再生，但纳米纤维结构对干细胞行为的影响在很大程度上是未知的，因为用于纳米纤维-细胞相互作用的生物材料系统不能排除细胞-细胞相互作用的干扰。

在这项研究中，我们开发了一种独特的微图案技术，将一个单一干细胞限制在纳米纤维微图案基质的微区内，因此可消除任何潜在的细胞间通信。纳米纤维微图案基质模拟了天然细胞外基质（ECM）的物理结构和化学成分，是通过静电纺丝，化学交联和紫外引发光刻相结合的方法制造。

与非纳米纤维结构相比，在纳米纤维微岛上培养的骨髓干细胞（BMSC）与体内细胞的形态更相似，更小的扩散区域，更少的粘着斑和更少的应力纤维。在纳米纤维微区上培养的BMSC也具有较高的碱性磷酸酶（ALP）活性，表明纳米纤维结构促进了BMSC分化。机制研究表明，纳米纤维通过FAK/RhoA/YAP1通路调节单个骨髓干细胞的成骨。

本研究开发的纳米纤维微图案基质是促进理解细胞-基质相互作用的优秀平台，最终为新型生物激发组织再生支架的开发提供了有用的新见解。

原始出处：

Chang B, Ma C, Liu X. Nanofibers regulate single bone marrow stem cell osteogenesis via FAK/RhoA/YAP1 pathway. ACS Appl Mater Interfaces. 2018 Sep 6. doi: 10.1021/acsami.8b11449.

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target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, 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    2018-12-29 xinmeili

    #YAP1#

    0

  2. 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    2019-01-01 gujh

    #YAP#

    0

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    2018-12-16 zhaozhouchifen

    #RhoA#

    0

  4. 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createdBy=3333505, createdName=gujh, createdTime=Tue Jan 01 05:21:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987702, encodeId=9a42198e702e7, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Dec 16 14:21:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640585, encodeId=ea3916405850d, content=<a href='/topic/show?id=78a4e22688' target=_blank style='color:#2F92EE;'>#FAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7226, encryptionId=78a4e22688, topicName=FAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a7722667526, createdName=12498a49m67暂无昵称, createdTime=Sat Oct 20 14:21:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956724, encodeId=81451956e24a8, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Nov 26 17:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655898, encodeId=532e165589809, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-10-20 12498a49m67暂无昵称

    #FAK#

    0

  5. 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target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-11-26 夏天与十三菇凉

    #FAC#

    0

  6. 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encryptionId=78a4e22688, topicName=FAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a7722667526, createdName=12498a49m67暂无昵称, createdTime=Sat Oct 20 14:21:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956724, encodeId=81451956e24a8, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Nov 26 17:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655898, encodeId=532e165589809, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2019-06-19 shanyongle

    #ACE#

    0

  7. 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target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2019-06-01 1249883fm19暂无昵称

    #纳米纤维#

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1715755, encodeId=26951e1575509, content=<a href='/topic/show?id=24051893e0f' target=_blank style='color:#2F92EE;'>#YAP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18937, encryptionId=24051893e0f, topicName=YAP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941632034462, createdName=xinmeili, createdTime=Sat Dec 29 21:21:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081905, encodeId=19cc2081905a3, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Tue Jan 01 05:21:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987702, encodeId=9a42198e702e7, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Dec 16 14:21:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640585, encodeId=ea3916405850d, content=<a href='/topic/show?id=78a4e22688' target=_blank style='color:#2F92EE;'>#FAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7226, encryptionId=78a4e22688, topicName=FAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a7722667526, createdName=12498a49m67暂无昵称, createdTime=Sat Oct 20 14:21:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956724, encodeId=81451956e24a8, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Nov 26 17:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655898, encodeId=532e165589809, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-09 yaanren

    #ACS#

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1715755, encodeId=26951e1575509, content=<a href='/topic/show?id=24051893e0f' target=_blank style='color:#2F92EE;'>#YAP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18937, encryptionId=24051893e0f, topicName=YAP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941632034462, createdName=xinmeili, createdTime=Sat Dec 29 21:21:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081905, encodeId=19cc2081905a3, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Tue Jan 01 05:21:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987702, encodeId=9a42198e702e7, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Dec 16 14:21:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640585, encodeId=ea3916405850d, content=<a href='/topic/show?id=78a4e22688' target=_blank style='color:#2F92EE;'>#FAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7226, encryptionId=78a4e22688, topicName=FAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a7722667526, createdName=12498a49m67暂无昵称, createdTime=Sat Oct 20 14:21:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956724, encodeId=81451956e24a8, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Nov 26 17:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655898, encodeId=532e165589809, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-09 zhaojie88

    #成骨#

    0

  10. [GetPortalCommentsPageByObjectIdResponse(id=1715755, encodeId=26951e1575509, content=<a href='/topic/show?id=24051893e0f' target=_blank style='color:#2F92EE;'>#YAP1#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18937, encryptionId=24051893e0f, topicName=YAP1)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=941632034462, createdName=xinmeili, createdTime=Sat Dec 29 21:21:00 CST 2018, time=2018-12-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2081905, encodeId=19cc2081905a3, content=<a href='/topic/show?id=c2971893397' target=_blank style='color:#2F92EE;'>#YAP#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=18933, encryptionId=c2971893397, topicName=YAP)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3333505, createdName=gujh, createdTime=Tue Jan 01 05:21:00 CST 2019, time=2019-01-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1987702, encodeId=9a42198e702e7, content=<a href='/topic/show?id=a3d81544104' target=_blank style='color:#2F92EE;'>#RhoA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15441, encryptionId=a3d81544104, topicName=RhoA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=524d95, createdName=zhaozhouchifen, createdTime=Sun Dec 16 14:21:00 CST 2018, time=2018-12-16, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1640585, encodeId=ea3916405850d, content=<a href='/topic/show?id=78a4e22688' target=_blank style='color:#2F92EE;'>#FAK#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7226, encryptionId=78a4e22688, topicName=FAK)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1a7722667526, createdName=12498a49m67暂无昵称, createdTime=Sat Oct 20 14:21:00 CST 2018, time=2018-10-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1956724, encodeId=81451956e24a8, content=<a href='/topic/show?id=7647e210ac' target=_blank style='color:#2F92EE;'>#FAC#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7210, encryptionId=7647e210ac, topicName=FAC)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdqq.qlogo.cn/qqapp/1103841572/B389FA68ECBF51BE2FE14093CF61F6AE/100, createdBy=eb8e2500096, createdName=夏天与十三菇凉, createdTime=Mon Nov 26 17:21:00 CST 2018, time=2018-11-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1655898, encodeId=532e165589809, content=<a href='/topic/show?id=2a011829d7' target=_blank style='color:#2F92EE;'>#ACE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=24, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1829, encryptionId=2a011829d7, topicName=ACE)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=635024767990, createdName=shanyongle, createdTime=Wed Jun 19 03:21:00 CST 2019, time=2019-06-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1635686, encodeId=df98163568658, content=<a href='/topic/show?id=1059e743357' target=_blank style='color:#2F92EE;'>#纳米纤维#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=77433, encryptionId=1059e743357, topicName=纳米纤维)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=64fe22519052, createdName=1249883fm19暂无昵称, createdTime=Sat Jun 01 20:21:00 CST 2019, time=2019-06-01, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1279282, encodeId=96ab12e928249, content=<a href='/topic/show?id=316d1882bc' target=_blank style='color:#2F92EE;'>#ACS#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=1882, encryptionId=316d1882bc, topicName=ACS)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=102a153, createdName=yaanren, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351818, encodeId=f8de135181843, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sun Sep 09 12:21:00 CST 2018, time=2018-09-09, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=343478, encodeId=d4173434e872, content=了解一下，谢谢分享！, beContent=null, objectType=article, channel=null, level=null, likeNumber=38, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cdnapi.center.medsci.cn/medsci/head/2019/12/23/2f51002e1349ccda5be11c1eea1e1e60.jpg, createdBy=a22097948, createdName=天地飞扬, createdTime=Fri Sep 07 22:46:29 CST 2018, time=2018-09-07, status=1, ipAttribution=)]
    2018-09-07 天地飞扬

    了解一下，谢谢分享！

    0

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