在线课堂：超详细解读——样本容量的估计

2015-05-21 MedSci MedSci原创

在科研设计之始，我们常被以下问题所困…… 主要终点、次要终点；纳入排除标准；随访实施；随机化方式；盲法实施；样本量；统计方案样本量—大？小？怎么办！！！！无论何种设计，均应考虑样本量的估算问题。样本量过小？——结果不稳定，检验效能过低，无法获得阳性结果（假阴性结果）样本量过大？——增加临床研究难度，造成人力、物力、时间和经济上的

在科研设计之始，我们常被以下问题所困……

主要终点、次要终点；纳入排除标准；随访实施；随机化方式；盲法实施；样本量；统计方案

样本量—大？小？怎么办！！！！

无论何种设计，均应考虑样本量的估算问题。
样本量过小？——结果不稳定，检验效能过低，无法获得阳性结果（假阴性结果）
样本量过大？——增加临床研究难度，造成人力、物力、时间和经济上的浪费，伦理问题，可能发现过于细微但没有临床意义的结果，
样本含量估计是指，根据具体的情况、基本信息和精确度要求，在保证研究结论具有一定可靠性的条件下，应用一定的统计方法确定最少的实验单位数，从而使实验结果达到一定的精确度，又不浪费人力、物力和时间

接下来将由MedSci临床研究学院新入驻讲师陈老师为各位带来关于样本量估算的问题。本次课程内容涉及以下知识以及PASS软件，请大家做好准备哟

1.估计样本含量的步骤

2.影响样本含量的基本参数

3.不同资料/试验类型的样本含量估计

4.均数比较的样本量估计

5.率的比较的样本含量估计（上/下）

6.样本相关性分析与Kappa test软件的使用

7.三大回归:线性回归、Logistic 回归、多重回归

8.生存分析：Cox 回归、Logrank Tests(freedman)、Logrank Tests (Lokatos)

点击此处，进入第一课堂：M1U46：样本量的估计(一)

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#插入话题

插入图片

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2015-12-25 zhzhxiang

#样本#

29 0
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2015-06-25 fatalmelanie

好有用

138 0
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2015-05-22 午夜星河

必须听

118 0
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2015-05-22 115.155.65.**

。为什么读喜欢用pass呢？连破解版的毒没有

22 0
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2015-05-21 zhouanxiu

可以评价，但是无法看完全部

114 0
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2015-05-21 zhouanxiu

。还不能看吧

109 0
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2015-05-21 jasonuclear

非常有用！！！

77 0
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2015-05-21 drylzheng

等待

81 0
[GetPortalCommentsPageByObjectIdResponse(id=1669341, encodeId=8c5716693410f, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Fri Dec 25 15:47:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29028, encodeId=5b2229028a9, content=好有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Thu Jun 25 16:49:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24537, encodeId=548f2453e46, content=必须听, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Fri May 22 12:12:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24532, encodeId=92502453277, content=。为什么读喜欢用pass呢？连破解版的毒没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.155.65.**, createdTime=Fri May 22 11:05:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24518, encodeId=679524518f8, content=可以评价，但是无法看完全部, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 21 23:22:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24517, encodeId=9b912451e4c, content=。还不能看吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 21 23:14:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24487, encodeId=68612448ed0, content=非常有用！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Thu May 21 18:35:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24481, encodeId=210424481cc, content=等待, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1de110573, createdName=drylzheng, createdTime=Thu May 21 18:07:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24480, encodeId=99f0244806a, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=117.136.0.**, createdTime=Thu May 21 18:05:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24478, encodeId=5be1244e8c2, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Thu May 21 17:56:00 CST 2015, time=2015-05-21, status=1, ipAttribution=)]
2015-05-21 117.136.0.**

期待

107 0
[GetPortalCommentsPageByObjectIdResponse(id=1669341, encodeId=8c5716693410f, content=<a href='/topic/show?id=9d7b620395d' target=_blank style='color:#2F92EE;'>#样本#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=62039, encryptionId=9d7b620395d, topicName=样本)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f33226554040, createdName=zhzhxiang, createdTime=Fri Dec 25 15:47:00 CST 2015, time=2015-12-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=29028, encodeId=5b2229028a9, content=好有用, beContent=null, objectType=article, channel=null, level=null, likeNumber=138, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=2be01625436, createdName=fatalmelanie, createdTime=Thu Jun 25 16:49:00 CST 2015, time=2015-06-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24537, encodeId=548f2453e46, content=必须听, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200609/ef6a57dbe7f1489dad7446b7c5217858/d5e4fe65996c4446a029b0f5d056abb1.jpg, createdBy=6b011518214, createdName=午夜星河, createdTime=Fri May 22 12:12:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24532, encodeId=92502453277, content=。为什么读喜欢用pass呢？连破解版的毒没有, beContent=null, objectType=article, channel=null, level=null, likeNumber=22, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=115.155.65.**, createdTime=Fri May 22 11:05:00 CST 2015, time=2015-05-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24518, encodeId=679524518f8, content=可以评价，但是无法看完全部, beContent=null, objectType=article, channel=null, level=null, likeNumber=114, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 21 23:22:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24517, encodeId=9b912451e4c, content=。还不能看吧, beContent=null, objectType=article, channel=null, level=null, likeNumber=109, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/mONcle9pic3yz0JbjHQ7nicJU7lHMOu0Itf3Zv3VBzEvK3k4AFPBXhiaxIRNGVI33GicoRXQEjkaasjdlWKwZuwcyhDP9Jibqt5ct/0, createdBy=f1281613275, createdName=zhouanxiu, createdTime=Thu May 21 23:14:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24487, encodeId=68612448ed0, content=非常有用！！！, beContent=null, objectType=article, channel=null, level=null, likeNumber=77, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160515/IMG57380B859AD1F1019.jpg, createdBy=2c5c1621956, createdName=jasonuclear, createdTime=Thu May 21 18:35:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24481, encodeId=210424481cc, content=等待, beContent=null, objectType=article, channel=null, level=null, likeNumber=81, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a1de110573, createdName=drylzheng, createdTime=Thu May 21 18:07:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24480, encodeId=99f0244806a, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=107, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=117.136.0.**, createdTime=Thu May 21 18:05:00 CST 2015, time=2015-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=24478, encodeId=5be1244e8c2, content=期待, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/Q0j4TwGTfTJUNfdk68bHutYruGyxbKDzPWH3agcmId19Yf94FiapyicN0LTg0jykhqIhjPQVdR08FGR399rBpZIg/132, createdBy=feae1624323, createdName=Dr.LV, createdTime=Thu May 21 17:56:00 CST 2015, time=2015-05-21, status=1, ipAttribution=)]
2015-05-21 Dr.LV

期待

60 0

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