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Neural Regen Res：黄芪甲苷促进坐骨神经再生的机制

2013-09-16 佚名 EurekAlert!中文版

黄芪甲苷坐骨神经
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黄芪甲苷是中药黄芪的主要活性成分，以往研究表明，具有抗炎、抗氧化、抗病毒、抗细胞凋亡、免疫调节，尤其对神经缺血有保护作用。那么，神经损伤后黄芪甲苷的保护作用是通过何种途径产生的呢？ 吉林大学药学院张晓红所在课题组进行的一项关于“The mechanism of astragaloside IV promoting sciatic nerve regeneration”

黄芪甲苷是中药黄芪的主要活性成分，以往研究表明，具有抗炎、抗氧化、抗病毒、抗细胞凋亡、免疫调节，尤其对神经缺血有保护作用。那么，神经损伤后黄芪甲苷的保护作用是通过何种途径产生的呢？

吉林大学药学院张晓红所在课题组进行的一项关于“The mechanism of astragaloside IV promoting sciatic nerve regeneration”的研究，离断小鼠坐骨神经并施行吻合建立坐骨神经损伤小鼠模型，每日腹腔注射黄芪甲苷10，5，2.5 mg/kg干预，以此观察黄芪甲苷在周围神经损伤的修复和再生中的作用和分子机制。

黄芪甲苷每日5 mg/kg.d腹腔注射坐骨神经损伤小鼠的髓鞘组织形态

图中所示高密度髓鞘呈天蓝色

结果发现，黄芪甲苷可促进小鼠坐骨神经再生和功能恢复，其机制与上调神经生长相关蛋白43的表达有关。作者认为，此结果为合理应用中药治疗周围神经损伤提供了理论依据。

文章发表在《中国神经再生研究（英文版）》杂志2013年8月第24期。

原文下载

Xiaohong Zhang, Jiajun Chen.The mechanism of astragaloside IV promoting sciatic nerve regeneration.NEURAL REGENERATION RESEARCH.August 2013.


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  1. [GetPortalCommentsPageByObjectIdResponse(id=2119042, encodeId=04702119042fd, content=<a href='/topic/show?id=b9091031981b' target=_blank style='color:#2F92EE;'>#黄芪甲苷#</a>是<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a><a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>的主要活性成分，以往研究表明，具有<a href='/topic/show?id=98c0553894c' target=_blank style='color:#2F92EE;'>#抗炎#</a>、<a href='/topic/show?id=6b1b553e2a6' target=_blank style='color:#2F92EE;'>#抗氧化#</a>、<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>、抗<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>、免疫调节，尤其对神经缺血有保护作用。这里讲<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>，不过进一步研究还是太少。 黄芪中的主要活性成分为<a href='/topic/show?id=2bbf10319ec5' target=_blank style='color:#2F92EE;'>#黄芪多糖#</a>(astragaluspolysaccharides)、<a href='/topic/show?id=e998105648f6' target=_blank style='color:#2F92EE;'>#黄芪皂苷#</a>(astragalussaponins)和<a href='/topic/show?id=f3b010564957' target=_blank style='color:#2F92EE;'>#黄芪异黄酮#</a>(isoflavones)。 另外，黄芪中的<a href='/topic/show?id=ddfa10565044' target=_blank style='color:#2F92EE;'>#环黄芪醇#</a>,也是现今发现的唯一一种<a href='/topic/show?id=017ce5693fe' target=_blank style='color:#2F92EE;'>#端粒酶#</a>激活剂,可增加端粒酶活性,所有具有抗<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>作用。但是，环黄芪醇含量极低，未来还需要依靠人工合成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103198, encryptionId=b9091031981b, topicName=黄芪甲苷), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=103196, encryptionId=9c2d1031961f, topicName=黄芪), TopicDto(id=55389, encryptionId=98c0553894c, topicName=抗炎), TopicDto(id=55372, encryptionId=6b1b553e2a6, topicName=抗氧化), TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒), TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡), TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生), TopicDto(id=103197, encryptionId=2bbf10319ec5, topicName=黄芪多糖), TopicDto(id=105648, encryptionId=e998105648f6, topicName=黄芪皂苷), TopicDto(id=105649, encryptionId=f3b010564957, topicName=黄芪异黄酮), TopicDto(id=105650, encryptionId=ddfa10565044, topicName=环黄芪醇), TopicDto(id=75693, encryptionId=017ce5693fe, topicName=端粒酶), TopicDto(id=90321, encryptionId=4c239032154, topicName=衰老)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:21:53 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1523764, encodeId=6bb11523e6448, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571804, encodeId=1b3515e1804d6, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2023-03-12 侠胆医心 来自上海

    #黄芪甲苷#是#中药##黄芪#的主要活性成分，以往研究表明，具有#抗炎#、#抗氧化#、#抗病毒#、抗#细胞凋亡#、免疫调节，尤其对神经缺血有保护作用。这里讲#神经再生#，不过进一步研究还是太少。 黄芪中的主要活性成分为#黄芪多糖#(astragaluspolysaccharides)、#黄芪皂苷#(astragalussaponins)和#黄芪异黄酮#(isoflavones)。 另外，黄芪中的#环黄芪醇#,也是现今发现的唯一一种#端粒酶#激活剂,可增加端粒酶活性,所有具有抗#衰老#作用。但是，环黄芪醇含量极低，未来还需要依靠人工合成。

    0

  2. [GetPortalCommentsPageByObjectIdResponse(id=2119042, encodeId=04702119042fd, content=<a href='/topic/show?id=b9091031981b' target=_blank style='color:#2F92EE;'>#黄芪甲苷#</a>是<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a><a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>的主要活性成分，以往研究表明，具有<a href='/topic/show?id=98c0553894c' target=_blank style='color:#2F92EE;'>#抗炎#</a>、<a href='/topic/show?id=6b1b553e2a6' target=_blank style='color:#2F92EE;'>#抗氧化#</a>、<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>、抗<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>、免疫调节，尤其对神经缺血有保护作用。这里讲<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>，不过进一步研究还是太少。 黄芪中的主要活性成分为<a href='/topic/show?id=2bbf10319ec5' target=_blank style='color:#2F92EE;'>#黄芪多糖#</a>(astragaluspolysaccharides)、<a href='/topic/show?id=e998105648f6' target=_blank style='color:#2F92EE;'>#黄芪皂苷#</a>(astragalussaponins)和<a href='/topic/show?id=f3b010564957' target=_blank style='color:#2F92EE;'>#黄芪异黄酮#</a>(isoflavones)。 另外，黄芪中的<a href='/topic/show?id=ddfa10565044' target=_blank style='color:#2F92EE;'>#环黄芪醇#</a>,也是现今发现的唯一一种<a href='/topic/show?id=017ce5693fe' target=_blank style='color:#2F92EE;'>#端粒酶#</a>激活剂,可增加端粒酶活性,所有具有抗<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>作用。但是，环黄芪醇含量极低，未来还需要依靠人工合成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103198, encryptionId=b9091031981b, topicName=黄芪甲苷), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=103196, encryptionId=9c2d1031961f, topicName=黄芪), TopicDto(id=55389, encryptionId=98c0553894c, topicName=抗炎), TopicDto(id=55372, encryptionId=6b1b553e2a6, topicName=抗氧化), TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒), TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡), TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生), TopicDto(id=103197, encryptionId=2bbf10319ec5, topicName=黄芪多糖), TopicDto(id=105648, encryptionId=e998105648f6, topicName=黄芪皂苷), TopicDto(id=105649, encryptionId=f3b010564957, topicName=黄芪异黄酮), TopicDto(id=105650, encryptionId=ddfa10565044, topicName=环黄芪醇), TopicDto(id=75693, encryptionId=017ce5693fe, topicName=端粒酶), TopicDto(id=90321, encryptionId=4c239032154, topicName=衰老)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:21:53 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1523764, encodeId=6bb11523e6448, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571804, encodeId=1b3515e1804d6, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2013-09-18 hxj0121

    #神经再生#

    0

  3. [GetPortalCommentsPageByObjectIdResponse(id=2119042, encodeId=04702119042fd, content=<a href='/topic/show?id=b9091031981b' target=_blank style='color:#2F92EE;'>#黄芪甲苷#</a>是<a href='/topic/show?id=5c1d22423c8' target=_blank style='color:#2F92EE;'>#中药#</a><a href='/topic/show?id=9c2d1031961f' target=_blank style='color:#2F92EE;'>#黄芪#</a>的主要活性成分，以往研究表明，具有<a href='/topic/show?id=98c0553894c' target=_blank style='color:#2F92EE;'>#抗炎#</a>、<a href='/topic/show?id=6b1b553e2a6' target=_blank style='color:#2F92EE;'>#抗氧化#</a>、<a href='/topic/show?id=a3b4554e19d' target=_blank style='color:#2F92EE;'>#抗病毒#</a>、抗<a href='/topic/show?id=bd5ce780493' target=_blank style='color:#2F92EE;'>#细胞凋亡#</a>、免疫调节，尤其对神经缺血有保护作用。这里讲<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>，不过进一步研究还是太少。 黄芪中的主要活性成分为<a href='/topic/show?id=2bbf10319ec5' target=_blank style='color:#2F92EE;'>#黄芪多糖#</a>(astragaluspolysaccharides)、<a href='/topic/show?id=e998105648f6' target=_blank style='color:#2F92EE;'>#黄芪皂苷#</a>(astragalussaponins)和<a href='/topic/show?id=f3b010564957' target=_blank style='color:#2F92EE;'>#黄芪异黄酮#</a>(isoflavones)。 另外，黄芪中的<a href='/topic/show?id=ddfa10565044' target=_blank style='color:#2F92EE;'>#环黄芪醇#</a>,也是现今发现的唯一一种<a href='/topic/show?id=017ce5693fe' target=_blank style='color:#2F92EE;'>#端粒酶#</a>激活剂,可增加端粒酶活性,所有具有抗<a href='/topic/show?id=4c239032154' target=_blank style='color:#2F92EE;'>#衰老#</a>作用。但是，环黄芪醇含量极低，未来还需要依靠人工合成。, beContent=null, objectType=article, channel=null, level=null, likeNumber=76, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=103198, encryptionId=b9091031981b, topicName=黄芪甲苷), TopicDto(id=22423, encryptionId=5c1d22423c8, topicName=中药), TopicDto(id=103196, encryptionId=9c2d1031961f, topicName=黄芪), TopicDto(id=55389, encryptionId=98c0553894c, topicName=抗炎), TopicDto(id=55372, encryptionId=6b1b553e2a6, topicName=抗氧化), TopicDto(id=55471, encryptionId=a3b4554e19d, topicName=抗病毒), TopicDto(id=77804, encryptionId=bd5ce780493, topicName=细胞凋亡), TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生), TopicDto(id=103197, encryptionId=2bbf10319ec5, topicName=黄芪多糖), TopicDto(id=105648, encryptionId=e998105648f6, topicName=黄芪皂苷), TopicDto(id=105649, encryptionId=f3b010564957, topicName=黄芪异黄酮), TopicDto(id=105650, encryptionId=ddfa10565044, topicName=环黄芪醇), TopicDto(id=75693, encryptionId=017ce5693fe, topicName=端粒酶), TopicDto(id=90321, encryptionId=4c239032154, topicName=衰老)], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/Random/55971dc507c93968175ce7cc1e177b372a83869f.jpg, createdBy=f63e4754896, createdName=侠胆医心, createdTime=Sun Mar 12 10:21:53 CST 2023, time=2023-03-12, status=1, ipAttribution=上海), GetPortalCommentsPageByObjectIdResponse(id=1523764, encodeId=6bb11523e6448, content=<a href='/topic/show?id=1c43e421182' target=_blank style='color:#2F92EE;'>#神经再生#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=74211, encryptionId=1c43e421182, topicName=神经再生)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9b0211549475, createdName=hxj0121, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1571804, encodeId=1b3515e1804d6, content=<a href='/topic/show?id=9e40414e44c' target=_blank style='color:#2F92EE;'>#坐骨神经#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=41474, encryptionId=9e40414e44c, topicName=坐骨神经)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=4cdc15767871, createdName=ycmayy, createdTime=Wed Sep 18 04:01:00 CST 2013, time=2013-09-18, status=1, ipAttribution=)]
    2013-09-18 ycmayy

    #坐骨神经#

    0