JCEM:低骨密度或与亚临床动脉粥样硬化无关

2014-01-08 desperado-c dxy

研究要点:该研究探讨骨矿密度与亚临床动脉粥样硬化之间的关系;发现仅在校正年龄后,女性受试者的总髋部骨密度与踝肱比呈正相关;在完全校正的性别特异性回归模型中,骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关。亚洲人中骨矿密度(BMD)与动脉粥样硬化之间相关性的临床意义尚不清楚。为了探讨BMD与亚临床动脉粥样硬化之间的关系,来自沈阳中国医科大学第一附属医院老年科白小涓教授及其团队进行了一项研究,

研究要点:

  • 该研究探讨骨矿密度与亚临床动脉粥样硬化之间的关系;
  • 发现仅在校正年龄后,女性受试者的总髋部骨密度与踝肱比呈正相关;
  • 在完全校正的性别特异性回归模型中,骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关。
亚洲人中骨矿密度(BMD)与动脉粥样硬化之间相关性的临床意义尚不清楚。为了探讨BMD与亚临床动脉粥样硬化之间的关系,来自沈阳中国医科大学第一附属医院老年科白小涓教授及其团队进行了一项研究,该研究发现低BMD与亚临床动脉粥样硬化无关。该研究结果在线发表在2013年11月18日的The Journal of Clinical Endocrinology & Metabolism杂志上,该杂志的影响因子为6.430。

该研究是在中国沈阳进行的一项社区横断面研究。共有385例年龄37-87岁的中国男性和女性受试者参与。使用双能X线吸收测定法测量受试者的总髋部和腰椎BMD。通过测量踝肱比(ABI)、脉搏波传导速度(PWV)和颈动脉内膜中层厚度(CIMT)评估动脉粥样硬化。使用多元回归分析研究BMD与亚临床动脉粥样硬化之间的关系。使用方差膨胀因子、条件指数和方差比例检查多重共线性。使用因子分析和主成分回归解决多重共线性问题。

该研究结果表明,正常BMD、低骨量和骨质疏松组之间未发现ABI、PWV和CIMT有差异。校正年龄后,女性受试者的总髋部BMD与ABI呈正相关。包括校正年龄、体重指数、吸烟状况、饮酒状况、绝经状态(女性)、收缩压、舒张压、甘油三酯、总胆固醇、高密度脂蛋白胆固醇、低密度脂蛋白胆固醇、空腹血糖、血清尿酸、估算肾小球滤过率、超敏C反应蛋白和纤维蛋白原的性别特异性回归模型中,校正年龄后,女性受试者的总髋部BMD与ABI相关,但在完全校正后,这种相关性仅有临界意义。在没有骨折病史的受试者中,完全校正后,总髋部BMD和腰椎BMD与ABI、PWV和CIMT无关。骨质疏松的风险与ABI、PWV和CIMT无关。

该研究发现,低BMD与用ABI、PWV和CIMT评估的亚临床动脉粥样硬化无关。

研究背景:

骨质疏松症和动脉粥样硬化都是伴随老龄化出现的多因素退行性疾病。尽管许多研究提示骨矿密度(BMD) 与动脉粥样硬化之间有相关性,但是,这些研究着重于冠心病(CAD)和钙化的动脉粥样硬化。此外,上述研究多局限于一种动脉粥样硬化的测量方法。近年来,一些其他的动脉粥样硬化测量方法被用于研究BMD和动脉粥样硬化的关系,其中,踝肱比(BMI)被用于测量下肢血流,脉搏波传导速度(PWV)被用于测量动脉硬度,颈动脉内膜中层厚度(CIMT)被用于测量动脉粥样硬化结构。然而,很少有研究同时使用多种动脉粥样硬化测量方法研究BMD与动脉粥样硬化之间的关系。而且,很少有研究探讨BMD与亚临床动脉粥样硬化之间关系。

原文出处:
Liang DK, Bai XJ, Wu B, Han LL, Wang XN, Yang J, Chen XM.Associations between bone mineral density and subclinical atherosclerosis: a cross-sectional study of a Chinese population.J Clin Endocrinol Metab. 2013 Nov 18. 【原文下载】

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1735798, encodeId=4da81e35798ee, content=<a href='/topic/show?id=cc4e2420687' target=_blank style='color:#2F92EE;'>#亚临床动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24206, encryptionId=cc4e2420687, topicName=亚临床动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1433999553, createdName=zhangbaojun, createdTime=Fri Apr 25 01:47:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062845, encodeId=3a532062845f5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Aug 12 17:47:00 CST 2014, time=2014-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944361, encodeId=f27819443610c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Nov 21 03:47:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777464, encodeId=bdc91e774648d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 17 20:47:00 CST 2014, time=2014-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6803, encodeId=3c2c6803a2, content=骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103a84153, createdName=Susan0806, createdTime=Mon Jan 13 15:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1735798, encodeId=4da81e35798ee, content=<a href='/topic/show?id=cc4e2420687' target=_blank style='color:#2F92EE;'>#亚临床动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24206, encryptionId=cc4e2420687, topicName=亚临床动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1433999553, createdName=zhangbaojun, createdTime=Fri Apr 25 01:47:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062845, encodeId=3a532062845f5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Aug 12 17:47:00 CST 2014, time=2014-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944361, encodeId=f27819443610c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Nov 21 03:47:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777464, encodeId=bdc91e774648d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 17 20:47:00 CST 2014, time=2014-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6803, encodeId=3c2c6803a2, content=骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103a84153, createdName=Susan0806, createdTime=Mon Jan 13 15:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=)]
    2014-08-12 achengzhao
  3. [GetPortalCommentsPageByObjectIdResponse(id=1735798, encodeId=4da81e35798ee, content=<a href='/topic/show?id=cc4e2420687' target=_blank style='color:#2F92EE;'>#亚临床动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24206, encryptionId=cc4e2420687, topicName=亚临床动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1433999553, createdName=zhangbaojun, createdTime=Fri Apr 25 01:47:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062845, encodeId=3a532062845f5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Aug 12 17:47:00 CST 2014, time=2014-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944361, encodeId=f27819443610c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Nov 21 03:47:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777464, encodeId=bdc91e774648d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 17 20:47:00 CST 2014, time=2014-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6803, encodeId=3c2c6803a2, content=骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103a84153, createdName=Susan0806, createdTime=Mon Jan 13 15:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1735798, encodeId=4da81e35798ee, content=<a href='/topic/show?id=cc4e2420687' target=_blank style='color:#2F92EE;'>#亚临床动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24206, encryptionId=cc4e2420687, topicName=亚临床动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1433999553, createdName=zhangbaojun, createdTime=Fri Apr 25 01:47:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062845, encodeId=3a532062845f5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Aug 12 17:47:00 CST 2014, time=2014-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944361, encodeId=f27819443610c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Nov 21 03:47:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777464, encodeId=bdc91e774648d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 17 20:47:00 CST 2014, time=2014-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6803, encodeId=3c2c6803a2, content=骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103a84153, createdName=Susan0806, createdTime=Mon Jan 13 15:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=)]
    2014-08-17 smallant2015
  5. [GetPortalCommentsPageByObjectIdResponse(id=1735798, encodeId=4da81e35798ee, content=<a href='/topic/show?id=cc4e2420687' target=_blank style='color:#2F92EE;'>#亚临床动脉粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=31, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=24206, encryptionId=cc4e2420687, topicName=亚临床动脉粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=1c1433999553, createdName=zhangbaojun, createdTime=Fri Apr 25 01:47:00 CST 2014, time=2014-04-25, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2062845, encodeId=3a532062845f5, content=<a href='/topic/show?id=14fb10264d7' target=_blank style='color:#2F92EE;'>#JCE#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=37, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10264, encryptionId=14fb10264d7, topicName=JCE)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=e656479, createdName=achengzhao, createdTime=Tue Aug 12 17:47:00 CST 2014, time=2014-08-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1944361, encodeId=f27819443610c, content=<a href='/topic/show?id=411de6300ad' target=_blank style='color:#2F92EE;'>#粥样硬化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=76300, encryptionId=411de6300ad, topicName=粥样硬化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=b30d401, createdName=huangshifeng, createdTime=Fri Nov 21 03:47:00 CST 2014, time=2014-11-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1777464, encodeId=bdc91e774648d, content=<a href='/topic/show?id=eb9610265ed' target=_blank style='color:#2F92EE;'>#JCEM#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10265, encryptionId=eb9610265ed, topicName=JCEM)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=2a4439169927, createdName=smallant2015, createdTime=Sun Aug 17 20:47:00 CST 2014, time=2014-08-17, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=6803, encodeId=3c2c6803a2, content=骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关, beContent=null, objectType=article, channel=null, level=null, likeNumber=119, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=103a84153, createdName=Susan0806, createdTime=Mon Jan 13 15:41:00 CST 2014, time=2014-01-13, status=1, ipAttribution=)]
    2014-01-13 Susan0806

    骨密度与踝肱比、脉搏波传导速度和颈动脉内膜中层厚度无关

    0