Clin Gastroenterology H: 肥胖和体重增加与非酒精性脂肪性肝病患者纤维化的进展相关

2019-02-10 MedSci MedSci原创

目前我们对体重变化对于非酒精性脂肪性肝病(NAFLD)患者肝纤维化进展的影响尚不清楚。因此,本项研究旨在评估体重变化和基线体重指数(BMI)与纤维化进展的关系。

背景与目的
目前我们对体重变化对于非酒精性脂肪性肝病(NAFLD)患者肝纤维化进展的影响尚不清楚。因此,本项研究旨在评估体重变化和基线体重指数(BMI)与纤维化进展的关系。

方法
研究人员对韩国40700名NAFLD成年人进行了一项前瞻性队列研究,随访时间中位数为6.0年。体重变化定义为在基线和随后的随访时测量的体重之间的差异。使用天冬氨酸氨基转移酶与血小板比率指数(APRI)评估从晚期纤维化的中低或高纤维化进展的概率。

结果
在275421.5人年的随访期间,有5454名APRI较低的受试者进展为中度或高度APRI。通过比较BMI为18.5-22.9 kg / m的受试者(BMI为18.5-22.9 kg / m 2)的BMI为23-24.9,25-29.9和≥30的受试者,确定APRI进展的多变量调整风险比(参考); 这些比率分别为1.13(95%CI,1.02-1.26),1.41(95%CI,1.28-1.55)和2.09(95%CI,1.86-2.36)。

结论
本项研究表明肥胖和体重增加与纤维化进展风险增加独立相关。保持正常的健康体重和预防体重增加可能有助于减少NAFLD患者的纤维化进展。

原始出处:

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time=2019-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504589, encodeId=445b150458938, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Feb 12 09:20:00 CST 2019, time=2019-02-12, status=1, ipAttribution=)]
  5. 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time=2019-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504589, encodeId=445b150458938, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Feb 12 09:20:00 CST 2019, time=2019-02-12, status=1, ipAttribution=)]
    2019-11-19 qjddjq
  6. 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  7. 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  8. 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time=2019-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1504589, encodeId=445b150458938, content=<a href='/topic/show?id=7730e85412' target=_blank style='color:#2F92EE;'>#Gastroenterology#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=7854, encryptionId=7730e85412, topicName=Gastroenterology)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=5fc29706655, createdName=chaojitidian, createdTime=Tue Feb 12 09:20:00 CST 2019, time=2019-02-12, status=1, ipAttribution=)]
    2019-08-09 许安
  9. 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有文献报道,赖氨酰氧化酶类似物-2可以通过催化胶原的交联促进肝细胞纤维化的发生。因此研究人员在非酒精性脂肪性肝炎引起的晚期纤维化患者进行了simtuzumab(一种针对赖氨酰氧化酶样2的单克隆抗体)的安全性和有效性的探究,以期检验其在治疗非酒精性脂肪性肝炎引起的晚期纤维化中的作用。