Am J Clin Nutr：钙摄入和个体冠状动脉钙化并无关联

近日，来自哈佛医学院的研究者通过研究揭示了，钙摄入和冠状动脉钙化并不关系，这就告知那些以补充钙质来增加骨质健康的成人，并不用担心自身血管钙化的问题。相关研究成果于11月7日刊登于国际杂志American Journal of Clinical Nutrition上。

冠状动脉钙化得分可以表现出心脏中钙化斑堵塞动脉的严重程度，同时也是心脏病发作的毒力指示器。研究者Elizabeth (Lisa) Samelson说，这项研究揭示了在钙摄入和老年人动脉粥样硬化指示之间的关系，食物或者添加物中高剂量的钙质摄入并不会增加冠状动脉钙化的风险。

本项研究中，研究者对平均年龄为60岁的1300个男、女性参与者进行了调查研究，研究包括问及参与者的饮食以及补充物，随后研究者对其冠状动脉进行了CT扫描。

近些年来，钙质补充物的摄入对心脏病发病风险及副作用的影响相关研究成为了热点领域，然而研究者总结道，目前临床的数据并不能显示钙质摄入对心脏病发病风险的副作用。而且研究者强调，合理的钙质摄入是安全并且有效的，对于50岁以上的女性和70岁以上的男性每日1200mg，对于50岁-70岁之间的男性每日1000mg即可。

这项报告告诉人们，按照规则推荐的钙质摄入量对于保护骨质健康是合理且安全的，并不用担心冠状动脉钙化的风险。

编译自：No Link Found Between Calcium Intake and Coronary Artery Calcification

doi:10.3945/​ajcn.112.044230
PMC:
PMID:

Calcium intake is not associated with increased coronary artery calcification: the Framingham Study

Elizabeth J Samelson, Sarah L Booth, Caroline S Fox, Katherine L Tucker, Thomas J Wang, Udo Hoffmann, L Adrienne Cupples, Christopher J O'Donnell, and Douglas P Kiel

Background: Adequate calcium intake is known to protect the skeleton. However, studies that have reported adverse effects of calcium supplementation on vascular events have raised widespread concern. Objective: We assessed the association between calcium intake (from diet and supplements) and coronary artery calcification, which is a measure of atherosclerosis that predicts risk of ischemic heart disease independent of other risk factors. Design: This was an observational, prospective cohort study. Participants included 690 women and 588 men in the Framingham Offspring Study (mean age: 60 y; range: 36–83 y) who attended clinic visits and completed food-frequency questionnaires in 1998–2001 and underwent computed tomography scans 4 y later in 2002–2005. Results: The mean age-adjusted coronary artery–calcification Agatston score decreased with increasing total calcium intake, and the trend was not significant after adjustment for age, BMI, smoking, alcohol consumption, vitamin D–supplement use, energy intake, and, for women, menopause status and estrogen use. Multivariable-adjusted mean Agatston scores were 2.36, 2.52, 2.16, and 2.39 (P-trend = 0.74) with an increasing quartile of total calcium intake in women and 4.32, 4.39, 4.19, and 4.37 (P-trend = 0.94) in men, respectively. Results were similar for dietary calcium and calcium supplement use. Conclusions: Our study does not support the hypothesis that high calcium intake increases coronary artery calcification, which is an important measure of atherosclerosis burden. The evidence is not sufficient to modify current recommendations for calcium intake to protect skeletal health with respect to vascular calcification risk.