Circ: Cardiovascular Interventions:当代严重症状性主动脉瓣狭窄患者不进行主动脉瓣置换术的原因和临床结局

2018-12-19 xiangting MedSci原创

这项当代研究中,三分之二的症状性主动脉瓣狭窄患者潜在适合进行AVR手术,并且预后不佳。

虽然主动脉瓣置换术(AVR)可以挽救生命,但是许多症状性主动脉瓣狭窄患者没有接受适当的治疗。这项研究旨在探讨一个当代队列中不进行AVR患者的特征、结局和原因。

对2017年3月以前未接受AVR治疗的548名严重症状性主动脉瓣狭窄患者进行分析。基于是否存在医疗无效,根据AVR的适当性对患者进行分组。评估了人口学、不进行AVR的原理和结局。有359名患者(65.5%)适合进行AVR,其余189名患者(34.5%)无效。潜在适合进行AVR的患者中,62.1%症状严重,74.4%未被建议进行AVR,40.1%为低危。患者拒绝最常见(54.6%),其他原因均为不正确的症状分配或主动脉瓣狭窄严重程度分类。与无效患者相比,潜在适合进行AVR的患者转至心脏病科或外科(85.2% vs 92.6%; P=0.01)和完成心脏团队评估的比率较低(10.6% vs 17.5%; P=0.02)。总体上仅有124名患者(22.6%)进行了姑息性咨询,适合进行AVR的患者中仅有10.0%进行姑息性咨询。总体而言,1年死亡率为54.7%,心衰住院率为19.3%。

这项当代研究中,三分之二的症状性主动脉瓣狭窄患者潜在适合进行AVR手术,并且预后不佳。大多数患者的心脏团队评估不完整,通常有严重的症状或病变严重程度被误解,并未通过姑息治疗评估。考虑到未接受AVR患者的潜在获益,需要进一步努力解决这些缺点。

原始出处:

Liang Tang. Contemporary Reasons and Clinical Outcomes for Patients With Severe, Symptomatic Aortic Stenosis Not Undergoing Aortic Valve Replacement. Circ: Cardiovascular Interventions. 14 December 2018.

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createdTime=Fri Dec 21 07:02:00 CST 2018, time=2018-12-21, status=1, ipAttribution=)]
    2019-05-09 quxin068
  5. 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createdTime=Fri Dec 21 07:02:00 CST 2018, time=2018-12-21, status=1, ipAttribution=)]
  6. 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  7. 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  8. 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