Nanotechnology:ZnO纳米颗粒包埋入TiO2纳米管的抗菌活性和抑炎作用

2018-04-04 MedSci MedSci原创

具有纳米级结构表面的钛(Ti)表现出优异的生物相容性和骨整合。但是,手术植入可能导致细菌感染和炎症反应,从而导致植入失败。在这项工作中,研究人员通过电沉积将不规则和纳米棒形状的ZnO纳米颗粒掺入到内径约50nm的TiO2纳米管(TNT)中。使用金黄色葡萄球菌评估纳入TiO2纳米管(TNTs/ZnO)中的ZnO的抗菌性能。结果显示,与TNT相比,锌离子可从纳米粒子中释放,抗菌效果提高达99.3%。在

具有纳米级结构表面的钛(Ti)表现出优异的生物相容性和骨整合。但是,手术植入可能导致细菌感染和炎症反应,从而导致植入失败。在这项工作中,研究人员通过电沉积将不规则和纳米棒形状的ZnO纳米颗粒掺入到内径约50nm的TiO2纳米管(TNT)中。

使用金黄色葡萄球菌评估纳入TiO2纳米管(TNTs/ZnO)中的ZnO的抗菌性能。结果显示,与TNT相比,锌离子可从纳米粒子中释放,抗菌效果提高达99.3%。在样品上培养巨噬细胞以确定其各自的抗炎特性。采用CCK-8法和活体死亡染色法评估巨噬细胞的增殖和活力,扫描电镜观察细胞形态。

结果表明,TNTs/ZnO对巨噬细胞的增殖和粘附具有明显的抑制作用,可用于预防慢性炎症和控制炎症反应。此外,ZnO纳米粒子锌离子的释放缓慢,这可能有利于骨整合。

综上所述,该研究结果表明,沉积在TNTs中的ZnO改善了其抗菌效果并减弱了钛基植入物的炎症反应,有助于增强植体的生物活性。

原始出处:

Yao S, Feng X, et al., Antibacterial activity and inflammation inhibition of ZnO nanoparticles embedded TiO2 nanotubes. Nanotechnology. 2018 Mar 29. doi: 10.1088/1361-6528/aabac1.

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    2018-10-26 shock_melon
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    2018-04-06 Jiaa

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    0

  4. 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  5. 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  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Apr 05 08:33:13 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302932, encodeId=b1263029323a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Apr 05 08:20:35 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 易水河

    纳米技术看来并不是科学幻想

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Apr 05 08:33:13 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302932, encodeId=b1263029323a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Apr 05 08:20:35 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 2227437833_79976374

    不错.可以学到很多东西.值得推荐.

    0

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createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo6Nx0VGA4QMDzOP8oAgnV4h51EjSfehJ9QxyiaSmw8PB56BhY8KXFSxHCibXrzcy4abrzSibXQPxJ9kzrLcJyhhB8a/0, createdBy=1d3b1672603, createdName=明月清辉, createdTime=Thu Apr 05 08:33:13 CST 2018, time=2018-04-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=302932, encodeId=b1263029323a, content=学习, beContent=null, objectType=article, channel=null, level=null, likeNumber=62, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c3da1990174, createdName=yfjms, createdTime=Thu Apr 05 08:20:35 CST 2018, time=2018-04-05, status=1, ipAttribution=)]
    2018-04-05 明月清辉

    谢谢分享.学习了

    0

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    2018-04-05 yfjms

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