Ann Rheum Dis:慢性炎症性疾病中的常见精神障碍

2019-03-11 xiangting MedSci原创

炎性疾病的初级治疗患者中抑郁和焦虑的发病率升高,特别是那些早发性炎性疾病患者。

关于初级治疗背景下炎症性疾病与抑郁和焦虑发作之间关联的证据存在不一致。这项研究旨在评估多系统和器官特异性炎性疾病中抑郁和焦虑的风险。

这是一项前瞻性队列研究,纳入来自英国临床实践研究数据链的初级治疗患者,这些患者于2001年1月1日至2016年12月31日期间被诊断为炎性疾病。这些患者根据年龄、性别、实践和指数日期与无炎性疾病的患者相匹配。研究暴露是7种慢性炎性疾病。临床诊断为抑郁和焦虑代表了感兴趣的结局指标。

在538707名参与者中,抑郁症的发病率从每1000人年14(严重银屑病)到每1000人年9(系统性血管炎),与对照组比较(每1000人年5-7)实质上更高。与匹配的对照组相比,炎性疾病中多种抑郁和焦虑事件的HRs高16%(HR,1.16,95%CI 1.12至1.21,p<0.001)。抑郁、焦虑的发病率与炎性疾病的起病年龄密切相关。早发性疾病中(<40岁)抑郁症的总体HR估算为1.90(95%CI 1.66至2.17,p<0.001),晚发性疾病中(≥60岁)为0.93(95%CI 0.90至1.09,p=0.80)。

炎性疾病的初级治疗患者中抑郁和焦虑的发病率升高,特别是那些早发性炎性疾病患者。尽管确切机制仍需要进一步研究,这一发现可能反映了潜在疾病对患者生活质量的影响。

原始出处:

Alexandru Dregan. Common mental disorders within chronic inflammatory disorders: a primary care database prospective investigation. Ann Rheum Dis. 07 March 2019.

本文系梅斯医学(MedSci)原创编译整理,转载需授权!

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (4)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1736816, encodeId=420d1e3681622, content=<a href='/topic/show?id=56bf6e024d4' target=_blank style='color:#2F92EE;'>#炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67024, encryptionId=56bf6e024d4, topicName=炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d7334182962, createdName=ms9651749636653578, createdTime=Mon Oct 28 04:10:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988556, encodeId=7b0b198855610, content=<a href='/topic/show?id=8be45356188' target=_blank style='color:#2F92EE;'>#慢性炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53561, encryptionId=8be45356188, topicName=慢性炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Wed Dec 11 08:10:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012971, encodeId=525c20129e126, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 28 17:10:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547207, encodeId=6b2c154e2074c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Mar 13 07:10:00 CST 2019, time=2019-03-13, status=1, ipAttribution=)]
  2. [GetPortalCommentsPageByObjectIdResponse(id=1736816, encodeId=420d1e3681622, content=<a href='/topic/show?id=56bf6e024d4' target=_blank style='color:#2F92EE;'>#炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67024, encryptionId=56bf6e024d4, topicName=炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d7334182962, createdName=ms9651749636653578, createdTime=Mon Oct 28 04:10:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988556, encodeId=7b0b198855610, content=<a href='/topic/show?id=8be45356188' target=_blank style='color:#2F92EE;'>#慢性炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53561, encryptionId=8be45356188, topicName=慢性炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Wed Dec 11 08:10:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012971, encodeId=525c20129e126, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 28 17:10:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547207, encodeId=6b2c154e2074c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Mar 13 07:10:00 CST 2019, time=2019-03-13, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1736816, encodeId=420d1e3681622, content=<a href='/topic/show?id=56bf6e024d4' target=_blank style='color:#2F92EE;'>#炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67024, encryptionId=56bf6e024d4, topicName=炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d7334182962, createdName=ms9651749636653578, createdTime=Mon Oct 28 04:10:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988556, encodeId=7b0b198855610, content=<a href='/topic/show?id=8be45356188' target=_blank style='color:#2F92EE;'>#慢性炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53561, encryptionId=8be45356188, topicName=慢性炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Wed Dec 11 08:10:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012971, encodeId=525c20129e126, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 28 17:10:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547207, encodeId=6b2c154e2074c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Mar 13 07:10:00 CST 2019, time=2019-03-13, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1736816, encodeId=420d1e3681622, content=<a href='/topic/show?id=56bf6e024d4' target=_blank style='color:#2F92EE;'>#炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67024, encryptionId=56bf6e024d4, topicName=炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=9d7334182962, createdName=ms9651749636653578, createdTime=Mon Oct 28 04:10:00 CST 2019, time=2019-10-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1988556, encodeId=7b0b198855610, content=<a href='/topic/show?id=8be45356188' target=_blank style='color:#2F92EE;'>#慢性炎症性疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=41, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=53561, encryptionId=8be45356188, topicName=慢性炎症性疾病)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0ad8182, createdName=axin009, createdTime=Wed Dec 11 08:10:00 CST 2019, time=2019-12-11, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2012971, encodeId=525c20129e126, content=<a href='/topic/show?id=7d69598468' target=_blank style='color:#2F92EE;'>#Dis#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=5984, encryptionId=7d69598468, topicName=Dis)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Thu Nov 28 17:10:00 CST 2019, time=2019-11-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1547207, encodeId=6b2c154e2074c, content=<a href='/topic/show?id=4ef26e01766' target=_blank style='color:#2F92EE;'>#炎症性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=67017, encryptionId=4ef26e01766, topicName=炎症性)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=09e813968720, createdName=12498dd9m15暂无昵称, createdTime=Wed Mar 13 07:10:00 CST 2019, time=2019-03-13, status=1, ipAttribution=)]

相关资讯

FASEB J:慢性炎症性疾病的新疗法

昆士兰大学分子生物科学研究所研究人员发现一个潜在的新方法可以治疗慢性炎症性疾病,如关节炎。教授David Fairlie和他的同事们已开发出一种实验性治疗方法,该方法已经被证明能有效减少关节炎模型症状和疾病发展。 Fairlie教授说,刺激人体内免疫细胞分泌的蛋白酶在消化、抵抗感染和伤口愈合中发挥重要作用。但在慢性炎症性疾病如关节炎中,这些不断刺激免疫细胞所释放的酶呈高浓度会引起炎症,导致组织损

Neurology:慢性炎症性神经病变存在脑膜增强

目的:为了评估2个学术研究医院,多发性硬化症(MS)与一些炎症和非炎症神经疾病患者,头颅MRI增强T2液体衰减反转恢复序列(FLAIR)成像显示脑膜增强(LME)特异性和发生率。方法:评估非MS或嗜神经病毒感染的254例患者3T增强 T2-FLAIR图像是否存在脑膜增强。根据临床诊断,患者被分为:(1)非MS的炎症性神经系统疾病;(2)非炎症性神经系统疾病;(3)人类T淋巴细胞白血病病毒(HTLV