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阿斯利康的Brilinta可改善轻度急性缺血性卒中或短暂性脑缺血发作后的预后

2020-01-27 Allan MedSci原创

缺血性卒中Brilinta替卡格雷
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阿斯利康周一报道，III期研究的主要结果显示，与单独使用阿司匹林相比，与阿司匹林联合Brilinta（替卡格雷）可显著降低急性缺血性卒中或短暂性脑缺血发作后中风和死亡的风险。

阿斯利康周一报道，III期研究的主要结果显示，与单独使用阿司匹林相比，与阿司匹林联合Brilinta（替卡格雷）可显著降低急性缺血性卒中或短暂性脑缺血发作后中风和死亡的风险。阿斯利康生物制药研发执行副总裁Mene Pangalos说：“我们期待与卫生当局分享详细结果”。

THALES试验随机入组了超过11,000名在治疗开始前24小时内有轻度急性缺血性中风或短暂性脑缺血发作的患者。在中风或脑缺血发后的24小时内将受试者随机分组。THALES试验首席研究员Clay Johnston指出：“THALES的发现表明，Brilinta与阿司匹林联用可降低这一关键时期潜在破坏性事件的风险”。


原始出处：

https://www.firstwordpharma.com/node/1696179?tsid=4

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    2022-09-17 小小医者

    #Brilinta#（即#替格瑞洛#）#缺血性卒中#

    0

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    2020-02-20 12498da4m32(暂无昵称)

    #缺血性卒#

    0

  3. 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    2020-02-26 liuquanmn

    #短暂性脑缺#

    0

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createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160806/IMG57A5698BDB0244113.jpg, createdBy=32a91358059, createdName=jyzxjiangqin, createdTime=Sat Feb 08 18:01:05 CST 2020, time=2020-02-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1289236, encodeId=5d8812892369e, content=<a href='/topic/show?id=cd268500578' target=_blank style='color:#2F92EE;'>#脑缺血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85005, encryptionId=cd268500578, topicName=脑缺血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=845e216, createdName=cqlidoudou, createdTime=Wed Jan 29 11:25:00 CST 2020, time=2020-01-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1026547, encodeId=e308102654e70, content=卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！, beContent=null, objectType=article, channel=null, level=null, likeNumber=49, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 27 23:25:00 CST 2020, time=2020-01-27, status=1, ipAttribution=)]
    2020-07-08 guihongzh

    #缺血性#

    0

  5. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 27 23:25:00 CST 2020, time=2020-01-27, status=1, ipAttribution=)]
    2020-10-28 12498ca5m95暂无昵称

    #短暂性#

    0

  6. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 27 23:25:00 CST 2020, time=2020-01-27, status=1, ipAttribution=)]
    2020-02-20 jyzxjiangqin

    可改善急性卒中的治疗。

    0

  7. 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topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f0620, createdName=健健, createdTime=Mon Jan 27 23:25:00 CST 2020, time=2020-01-27, status=1, ipAttribution=)]
    2020-02-08 jyzxjiangqin

    阿斯利康社会责任！

    0

  8. 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    2020-01-29 cqlidoudou

    #脑缺血#

    0

  9. 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    2020-01-27 健健

    卒中虽然是临床上常见病，溶栓，取栓等血管内治疗也很成熟，但是仍然有很多未知问题有待认知！

    0

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Stroke：缺血性卒中后的抑郁症状

由此可见，首次缺血性卒中后9个月，对于卒中幸存者和家庭照看人员抑郁症状高发较为常见，但有临床抑郁风险的抑郁症状发生率比之前报道的要低。患者和照看人员对抑郁症的预测因素有所不同，并且照看标准应纳入家庭照看因素。

Stroke：西洛他唑与阿司匹林对缺血性卒中高危脑出血患者的疗效比较

由此可见，西洛他唑对存在多种脑微出血且在白质广泛变化之前的缺血性卒中患者可能更有益。

Nat Commun：基因组风险评分可提供与缺血性卒中的临床危险因素相当的预测性能

研究人员估计需要减少具有不同基因组风险水平的个体可改变的风险因素，并建议对于metaGRS高的个体，达到当前指南推荐的危险因素水平可能不足以减轻IS风险。

Neurology：血清维生素B12和叶酸与MTHFR基因型相互作用对缺血性卒中风险的影响

由此可见，在叶酸和B12含量均低的高血压患者中，首次缺血性卒中的风险明显更高。叶酸治疗对低叶酸和B12的CC基因型个体以及高叶酸和B12的TT基因型个体效果最明显。

Neurology：青少年急性缺血性卒中

由此可见，青少年的缺血性卒中强调在治疗中需要多学科协作，再通治疗似乎可行且安全。

Neurology：阿尔茨海默病患者出血性和缺血性卒中风险

由此可见，与具有相似风险特征的非AD对照相比，AD患者出血性卒中而非缺血性卒中的风险更高。