BMC Gastroenterology: 中国三级医院溃疡性结肠炎患者艰难梭菌感染的回顾性分析

2019-02-23 不详 MedSci原创

有文献报道艰难梭菌感染(CDI)对溃疡性结肠炎(UC)患者的影响越来越大。因此,研究人员进行了一项回顾性研究,以确定UC患者CDI的发生率,临床特征,危险因素和预后情况。

背景
有文献报道艰难梭菌感染(CDI)对溃疡性结肠炎(UC)患者的影响越来越大。因此,研究人员进行了一项回顾性研究,以确定UC患者CDI的发生率,临床特征,危险因素和预后情况。

方法
研究人员收集了2010年1月至2015年12月间中国一家三级医院住院的UC患者的临床资料。通过酶免疫测定法在UC患者中测试粪便样品的艰难梭菌毒素A和B(CDAB)。通过临床症状和阳性CDAB试验诊断UC患者的CDI,并且每个病例按以1:2的比例匹配CDI阴性的UC患者。使用单变量和二元逻辑回归分析来测量有和没有CDI的UC患者之间的差异。

结果
381例UC患者中有34例(8.92%)为CDAB阳性。研究前3个月内抗生素暴露(P  = 0.004),研究前1个月内住院治疗(P  = 0.025),全身使用类固醇(P  = 0.002)和活动性巨细胞病毒(CMV)感染(P  = 0.001) 等指标中CDI高于非CDI患者。二元logistic回归分析显示CMV感染与CDI相关(优势比= 13.502,95%置信区间1.307-139.512,P  = 0.029)。具有艰难梭菌和CMV共感染的UC患者具有更严重的结肠镜特征。

结论
最近使用抗生素,住院前和全身使用类固醇增加了CDI的风险。CMV感染是UC患者CDI的独立危险因素。

原始出处:

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    2019-08-09 仁医06
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    2019-02-26 许安
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    2019-11-19 nymo
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