Diabetes Care:碳水化合物的摄入量会影响胰高血糖素对轻度低血糖的治疗效果

2016-10-26 MedSci MedSci原创

研究对象为1型糖尿病患者,分组为等热量的高碳水化合物饮食(HCD)与低碳水化合物饮食(LCD),比较两组患者轻度低血糖后胰高血糖素恢复血糖(PG)的能力。十例使用胰岛素泵治疗的1型糖尿病患者随机完成1周的HCD(> 250克/天)和1周的LCD(<50克/天)。每一周后,在空腹状态下,通过胰岛素丸诱导轻度低血糖。当PG达到3.9 mmol/L,皮下注射100 µg胰高血糖素,2小时后予以50

研究对象为1型糖尿病患者,分组为等热量的高碳水化合物饮食(HCD)与低碳水化合物饮食(LCD),比较两组患者轻度低血糖后胰高血糖素恢复血糖(PG)的能力。

十例使用胰岛素泵治疗的1型糖尿病患者随机完成1周的HCD(> 250克/天)和1周的LCD(<50克/天)。每一周后,在空腹状态下,通过胰岛素丸诱导轻度低血糖。当PG达到3.9 mmol/L,皮下注射100 µg胰高血糖素,2小时后予以500 µg胰高血糖素。

与HCD相比,LCD导致PG的增量更低(第一次予以胰高血糖素,平均±SEM:1.3±0.3 vs. 2.7±0.4 mmol/L,P = 0.002;第二次予以胰高血糖素,平均±SEM:4.1 ± 0.2 vs. 5.6 ± 0.5 mmol/L, P = 0.002)。两种情况下的胰岛素、胰高血糖素和甘油三酯浓度没有显着差异。

LCD降低了胰高血糖素对轻度低血糖的治疗效果。使用低剂量的胰高血糖素纠正低血糖时,应考虑患者碳水化合物的摄入量。

原始出处:

Ajenthen Ranjan,et al.Low Carbohydrate Diet Impairs the Effect of Glucagon in the Treatment of Insulin-Induced Mild Hypoglycemia: A Randomized Cross-Over Study.Diabetes Care 2016 Oct

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    2017-10-07 lmm397
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  7. 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href='/topic/show?id=9b04641580e' target=_blank style='color:#2F92EE;'>#水化#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64158, encryptionId=9b04641580e, topicName=水化)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f1276671681, createdName=yuanming9, createdTime=Fri Oct 28 12:40:00 CST 2016, time=2016-10-28, status=1, ipAttribution=)]
    2016-10-30 xyfg98

    谢谢分享!

    0

  8. 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    2016-10-28 hbwxf
  9. 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    2016-10-28 yuanming9

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