致幻蘑菇的潜在医用价值:治疗抑郁、临终关怀...

2016-05-19 Seven L MedSci原创

提到荷兰你想到的是什么?郁金香?同性恋?还是阿姆斯特丹街头巷尾的蘑菇店。不得不承认,阿姆斯特丹的致幻蘑菇吸引了很大一部分人,毕竟那玩意儿在很多地方都是被禁止的,得不到的永远在骚动......一、当前的研究近期发表在The Lancet Psychiatry的研究称,致幻蘑菇可以治疗抑郁!存在于几种蘑菇中的赛洛西宾以“致幻作用”为特征,最近的研究表明,它对酒精依赖、临终焦虑症和强迫症(OCD)患

提到荷兰你想到的是什么?郁金香?同性恋?还是阿姆斯特丹街头巷尾的蘑菇店。不得不承认,阿姆斯特丹的致幻蘑菇吸引了很大一部分人,毕竟那玩意儿在很多地方都是被禁止的,得不到的永远在骚动......



一、当前的研究

近期发表在The Lancet Psychiatry的研究称,致幻蘑菇可以治疗抑郁

存在于几种蘑菇中的赛洛西宾以“致幻作用”为特征,最近的研究表明,它对酒精依赖、临终焦虑症和强迫症(OCD)患者有益。还有证据表明,先前使用过致幻剂的人群心理困扰和自杀可能更低(相比使用其他物质的人群)。

目前认知行为疗法(CBT)和抗抑郁药物是抑郁症常用的治疗方法,但约20%的患者对这些治疗没有反应,许多患者还会复发。

与现有的抑郁药类似,裸盖菇素以大脑中的血清素受体为目标。无论是人还是动物的脑图像研究均表明,裸盖菇素对大脑的影响与其他抗抑郁药治疗相似。

因此,存在于200多种蘑菇中具神经致幻作用的裸盖菇素可能对治疗抑郁症有益!

来自英国帝国理工学院的Robin Carhart-Harris博士招募了12位参与者,调查裸盖菇素与抑郁症的联系。

这12名参与者男女各半,并且都是中度至重度抑郁症患者,平均病程有17.8年,各种治疗都不见成效。所有参与者都进行过两个疗程的抗抑郁药物治疗,每次都治疗6周或以上,但是无效。还有11名患者参加了心理治疗课程,也没见有什么缓解或好转。

所有参与者都没有精神障碍的个人史或家族病史,也没有自杀史,也不存在药物或酒精依赖。

研究人员在第一周让患者服用含有10毫克裸盖菇素的胶囊,第二周则提高剂量,服用含有25毫克裸盖菇素的胶囊。服用胶囊30-60分钟后出现致幻效果,2-3小时达到高峰,患者在服药6小时候后离开医院。在治疗后对患者进行MRI随访。

患者的服药环境需要描述一下。患者躺在治疗室,一个有灯光和音乐的特殊房间,还有2名精神科医生伴随其左右(分别在床的两侧)。治疗室在整个过程中对患者的感觉进行支持和检查。

研究结果显示,所有患者在经过至少三周的治疗后,抑郁症状均有一定程度的缓解。用药三个月后,7名患者的抑郁症持续改善,表现减少,其中5名患者进入了缓解期。

并且整个研究过程中没有出现严重不良反应。但这些志愿者在服药前和用药时均表现出轻微的焦虑,不过这些表现也符合预期。

虽然本次研究的样本量小,缺乏对照组,不过也为抑郁症的研究开拓了新方向,给精神病患者带来了福音。希望以后能有更多的相关研究!

二、先前的研究

2014年10月,包括此次研究两位主要作者在内的国际研究小组,对裸盖菇素对大脑的影响进行了研究。试验组和对照组分别被注射2毫克的裸盖菇素和2毫克的安慰剂,然后通过功能性磁共振成像 (fMRI) 进行对比。

通常情况下,大脑的活动依靠特定的神经网络。注射裸盖菇素会导致其脑部活动飘忽不定,就好比在高速路上,有人开着四驱车横冲直撞,可以去到任何想去的地方。

但是进一步研究中研究人员发现,这种看似混乱的新的脑部活动并不是杂乱无章的,只是形成了具有清晰样式的不同模式,这是一种新型的“高速公路”。

下面是正常人脑 (a) 和服用了裸盖菇素的人脑部 (b) 联结对比图:



在本质上,研究人员发现裸盖菇素能够暂时性地改变整个脑部组织框架,建立新的联结,进而让人经历一些神奇的事情,比如看到声音,或者听到色彩。在2014年研究人员就提出,裸盖菇素可能具有抗抑郁作用。

2012年伦敦帝国学院神经学家David Nutt进行的另一项研究也给出了相似的结论。

服用裸盖菇素后,与自我意识控制相关的平时保持静默状态的区域会被激活。Nutt认为,对于抑郁患者,其自我意识区域的大脑回路过强,脑部的联结过多。通过对这些联结的疏导,并建立新的通路,或许可以缓解抑郁患者的消极思维和自我批判的情感,带来放松。

还有一些零碎的研究表明,裸盖菇素能够显著改变人格中“开放向性”要素,“开放性”高的人往往爱好广泛,并且具有创造性。裸盖菇素可用于癌症晚期病人的临终关怀,0.2毫克/千克的剂量就可以改变焦虑紧张的心情。

三、致幻蘑菇知多少



致幻蘑菇是包含致幻化合物裸盖菇碱和脱磷酸裸盖菇素的蘑菇。在史前时代就已经被人类使用,主要是作为宗教致幻剂和娱乐性药物。其实现在可以食用的致幻蘑菇是蘑菇孢子,而不是真正意义上的蘑菇,真正的致幻蘑菇在荷兰也是被禁止的。

1971年,裸盖菇碱和脱磷酸裸盖菇素在联合国公约附表中被列为精神药物,因为潜在的滥用潜力,不被允许用于医疗,不过联合国禁毒公约里没有该物质。虽然致幻蘑菇遭到了许多国家的控制和禁止,但是新鲜形式的致幻蘑菇在一些地区仍是合法的。比如在英国,致幻蘑菇晒干后是非法的,但是新鲜的却是合法的。不过鉴于巨大的社会压力,2005年英国对新鲜致幻蘑菇也禁止了。2008年11月29日,荷兰宣布从2008年12月1日起,禁止种植和使用裸盖菇碱含真菌。

有机会去荷兰的亲们可以尝试下致幻蘑菇......没机会的就在国内吃香菇、金针菇、大头菇、杏鲍菇......
原始出处:

silocybin with psychological support for treatment-resistant depression: an open-label feasibility study, Robin L Carhart-Harris et al., Lancet Psychiatry, http://dx.doi.org/10.1016/ S2215-0366(16)30065-7 , published 17 May 2016

Magic mushroom compound could help treat depression.MNT.19 May 2016.

Magic mushrooms appear to ease long-term depression, studies find.ScienceAlert.17 MAY 2016

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    2022-11-04 lifestar

    裸盖菇素(psilocybin)显示出与常见#抑郁症#治疗药物(5 -羟色胺能和谷氨酰胺能药物)的联合活性。此外,裸盖菇素(psilocybin)具有更低的#成瘾#倾向和毒性作用,且通常与长期知觉、认知或神经功能障碍没有关系。 不过#Psilocybin##裸盖菇素#)在人体内被代谢为#psilocin##脱磷酸裸盖菇素#),后者与5-HT2AR结合发挥作用。#重度抑郁症##抑郁#应有效!!#致幻##临终关怀#

    0

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  3. 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2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570812, encodeId=0cd515e0812f7, content=<a href='/topic/show?id=ace42309edc' target=_blank style='color:#2F92EE;'>#临终#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23097, encryptionId=ace42309edc, topicName=临终)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=)]
    2016-09-30 1e10c84am36(暂无匿称)

    拜读,好文

    0

  4. 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    2016-09-18 ylzr123

    赞一个!好文章拜读了,认真学习了。

    0

  5. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:18:58 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129831, encodeId=7286129831c5, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 06:27:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106623, encodeId=c820106623d6, content=深度好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, 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2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570812, encodeId=0cd515e0812f7, content=<a href='/topic/show?id=ace42309edc' target=_blank style='color:#2F92EE;'>#临终#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23097, encryptionId=ace42309edc, topicName=临终)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=)]
    2016-08-29 ylzr123

    深度好文,值得学习,赞!

    0

  6. 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  7. 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encodeId=5cec135322156, content=<a href='/topic/show?id=33292309808' target=_blank style='color:#2F92EE;'>#临终关怀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23098, encryptionId=33292309808, topicName=临终关怀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570499, encodeId=da4d15e04993a, content=<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efbb15667433, createdName=楚秀娟, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570812, encodeId=0cd515e0812f7, content=<a href='/topic/show?id=ace42309edc' target=_blank style='color:#2F92EE;'>#临终#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23097, encryptionId=ace42309edc, topicName=临终)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=)]
  8. [GetPortalCommentsPageByObjectIdResponse(id=2098406, encodeId=4eaf2098406c6, content=裸盖菇素(psilocybin)显示出与常见<a href='/topic/show?id=91cf549e3f1' target=_blank style='color:#2F92EE;'>#抑郁症#</a>治疗药物(5 -羟色胺能和谷氨酰胺能药物)的联合活性。此外,裸盖菇素(psilocybin)具有更低的<a href='/topic/show?id=494254045cf' target=_blank style='color:#2F92EE;'>#成瘾#</a>倾向和毒性作用,且通常与长期知觉、认知或神经功能障碍没有关系。 不过<a href='/topic/show?id=02ab1480308' target=_blank style='color:#2F92EE;'>#Psilocybin#</a>(<a href='/topic/show?id=057690433f4' target=_blank style='color:#2F92EE;'>#裸盖菇素#</a>)在人体内被代谢为<a href='/topic/show?id=fcf310498686' target=_blank style='color:#2F92EE;'>#psilocin#</a>(<a href='/topic/show?id=3edf10498ec7' target=_blank style='color:#2F92EE;'>#脱磷酸裸盖菇素#</a>),后者与5-HT2AR结合发挥作用。<a href='/topic/show?id=236a958195c' target=_blank style='color:#2F92EE;'>#重度抑郁症#</a><a href='/topic/show?id=0a0b5496306' target=_blank style='color:#2F92EE;'>#抑郁#</a>应有效!!<a href='/topic/show?id=7a27104988d3' target=_blank style='color:#2F92EE;'>#致幻#</a><a 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzdAIB7UwTkHt6fQkBP8ictliaXtc5gCUmYdAW1sAETC2nhO3q6YjRHkUibyOCtP8ibmXNObTyd63A076/0, createdBy=d4111948983, createdName=1e10c84am36(暂无匿称), createdTime=Fri Sep 30 15:18:58 CST 2016, time=2016-09-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=129831, encodeId=7286129831c5, content=赞一个!好文章拜读了,认真学习了。, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Sun Sep 18 06:27:00 CST 2016, time=2016-09-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=106623, encodeId=c820106623d6, content=深度好文,值得学习,赞!, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/NUyjXTCJjo7s7ZCKOmmbBTD6nE7gcd5OZpvyGEzkxBP3S275k5ZJVrsPkotZhBglRHM9rKvcj1OgkssqhcnoPw8zIaMZTF8c/0, createdBy=4c441942088, createdName=ylzr123, createdTime=Mon Aug 29 07:53:00 CST 2016, time=2016-08-29, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2023868, encodeId=5e0e20238686e, content=<a href='/topic/show?id=99ff64628fb' target=_blank style='color:#2F92EE;'>#治疗抑郁#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=64628, encryptionId=99ff64628fb, topicName=治疗抑郁)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=f5e185, createdName=zlawrance, createdTime=Mon Jul 04 22:02:00 CST 2016, time=2016-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1353221, encodeId=5cec135322156, content=<a href='/topic/show?id=33292309808' target=_blank style='color:#2F92EE;'>#临终关怀#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23098, encryptionId=33292309808, topicName=临终关怀)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570499, encodeId=da4d15e04993a, content=<a href='/topic/show?id=5f2288493b1' target=_blank style='color:#2F92EE;'>#蘑菇#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88493, encryptionId=5f2288493b1, topicName=蘑菇)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=efbb15667433, createdName=楚秀娟, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1570812, encodeId=0cd515e0812f7, content=<a href='/topic/show?id=ace42309edc' target=_blank style='color:#2F92EE;'>#临终#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=23097, encryptionId=ace42309edc, topicName=临终)], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/aLGWoFXAyMbIu3qymFOyheQLjPSX3OUs5GmkyBlcCOwTPIeq3why9NGibxxUqYo6hcx8qZLHZFgNPnBK1yzWeOFpyg2OnWOt0/0, createdBy=fa4716, createdName=仁心济世, createdTime=Sat May 21 00:02:00 CST 2016, time=2016-05-21, status=1, ipAttribution=)]
    2016-05-21 楚秀娟
  9. 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