BMC Gastroenterology:小儿慢性胰腺炎患者脂肪泻的危险因素

2019-02-24 不详 MedSci原创

患有慢性胰腺炎(CP)的儿童总是容易出现脂肪泻,目前对于此现象还没有文献进行研究。本研究旨在确定儿科CP患者脂肪泻的发生率和危险因素。

背景
患有慢性胰腺炎(CP)的儿童总是容易出现脂肪泻,目前对于此现象还没有文献进行研究。本研究旨在确定儿科CP患者脂肪泻的发生率和危险因素。

方法
研究人员收集了2000年1月至2013年12月入住的CP患者。根据CP发病年龄,将患者分配到儿科(<18岁)和成人组。计算两组的脂肪泻累积率。分别确定了两组的危险因素。

结果
共有2153名患者接受了本项研究的实验,其中13.5%为儿童。整个队列的中位随访时间为7.6年。儿科CP发病的平均年龄和诊断年龄分别为11.622岁和19.727岁。在儿科组中有46名患者(46 / 291,15.8%)和成人组中447名患者(447 / 1862,24.0%)检测到脂肪泻。CP发病年龄(危险比[HR],1.121),糖尿病(DM,HR,51.140)和重症急性胰腺炎(SAP,HR,13.946)被确定为儿科组脂肪泻的危险因素。

结论
CP,DM和SAP发病年龄是儿科CP患者发生脂肪泻的危险因素。

原始出处:

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    2019-10-28 许安
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