NEJM:短暂性脑缺血发作或轻微脑卒中患者5年内后续中风风险研究

2018-05-18 zhangfan MedSci原创

研究发现短暂性脑缺血发作或轻微脑卒中患者5年内中风及血管事件风险增加,其中第1年内风险最高,第2-5年的累积风险与第1年相当

短暂性脑缺血发作(TIA)或轻微脑卒中患者的后继长期中风和其他血管事件风险尚未被充分评估。近日研究人员在21个国家开展大规模临床研究,考察TIA或轻微脑卒中后5年的中风及血管事件风险。

脑血管事件发生后7天以内患者参与研究,主要终点为中风、急性冠状动脉综合征或心血管死亡的复合终点。

总计3847名患者参与研究,总计469人发生终点事件(累积发生率为12.9%),其中235起事件(50.1%)发生在基线事件后第2-5年。5年中,中风345人(累积中风率9.5%),其中149人(43.2%)在基线事件后第2-5年中风。参与者全因死亡、心血管死亡、颅内出血以及大出血率分别为10.6%、2.7%、 1.1%和1.5%。多因素模型中,同侧大动脉粥样硬化、心脏栓塞、基线ABCD2评分中风的风险(0-7分)高于4分以上人群的后继中风风险增加。

研究发现短暂性脑缺血发作或轻微脑卒中患者5年内中风及血管事件风险增加,其中第1年内风险最高,第2-5年的累积风险与第1年相当。

原始出处:

Pierre Amarenco et al. Five-Year Risk of Stroke after TIA or Minor Ischemic Stroke. N Engl J Med. May 16, 2018.

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    2018-06-25 jyzxjiangqin

    短暂性脑缺血发作.

    0

  8. 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    2018-05-31 jyzxjiangqin

    短暂性脑缺血发作.

    0

  9. 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    2018-05-19 baihao215

    恭喜TIAregistry.org

    0

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