JAHA:抽烟会增加外周动脉疾病风险

2019-01-24 MedSci MedSci原创

与非西班牙裔的白种人相比,黑种人的外周动脉疾病(PAD)发病率要明显更高,但是抽烟在黑种人的PAD发生中的影响尚不清楚。本研究的目的旨在评估抽烟对黑种人PAD发生的影响。本研究纳入了JHS临床研究中的5306名黑种人,根据自我报告将研究对象分为现在抽烟、以前抽烟(至少400支)和从不抽烟,分析结果显示,有3579名(68%)研究对象从不抽烟,986名(19%)过去抽烟,693名(13%)现在抽烟,

与非西班牙裔的白种人相比,黑种人的外周动脉疾病(PAD)发病率要明显更高,但是抽烟在黑种人的PAD发生中的影响尚不清楚。本研究的目的旨在评估抽烟对黑种人PAD发生的影响。

本研究纳入了JHS临床研究中的5306名黑种人,根据自我报告将研究对象分为现在抽烟、以前抽烟(至少400支)和从不抽烟,分析结果显示,有3579名(68%)研究对象从不抽烟,986名(19%)过去抽烟,693名(13%)现在抽烟,在经过协变量调整分析后,与从不抽烟者相比,现在抽烟者的踝臂指数<1的风险更高(OR:2.2, 95% CI, 1.5–3.3),腹主动脉钙化的风险更高(OR:8.4, 95% CI, 5.8–12.0)。当将抽烟分层分析后,那些每天抽烟大于20支的黑种人的各个亚临床PAD风险均高于小于20支的,提示存在剂量依赖效应。

研究结果显示,抽烟会增加黑种人的外周动脉疾病发生风险,且呈剂量依赖性。

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    2019-01-26 zhaohui6731
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    2019-01-26 gujh
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