Neurology:有脑血管疾病的女性应慎用钙补充剂,小心增加老年痴呆风险

2016-08-18 fsy 译 MedSci原创

根据一项新的研究,钙补充剂可能会增加老年女性卒中或有其他脑血管疾病迹象患者的老年痴呆症风险。该研究于2016年8月17日在线发表在美国神经病学学会的医学杂志Neurology®上。脑血管疾病是一组影响大脑中血液流动的疾病。这些疾病(包括卒中)是美国人群死亡的第五大原因,并增加患痴呆症的风险。“骨质疏松症是老年人的常见问题。由于缺钙可导致骨质疏松症,因此指南建议每日钙摄入量为1000-1200毫克。

根据一项新的研究,钙补充剂可能会增加老年女性卒中或有其他脑血管疾病迹象患者的老年痴呆症风险。该研究于2016年8月17日在线发表在美国神经病学学会的医学杂志Neurology®上。

脑血管疾病是一组影响大脑中血液流动的疾病。这些疾病(包括卒中)是美国人群死亡的第五大原因,并增加患痴呆症的风险。

骨质疏松症是老年人的常见问题。由于缺钙可导致骨质疏松症,因此指南建议每日钙摄入量为1000-1200毫克。仅通过饮食达到此推荐量是很困难的,所以钙补充剂被广泛使用,”该研究的作者,瑞典哥德堡大学Silke Kern说。“然而,最近使用补充剂及其对健康的影响受到了质疑。”

这项研究纳入了700名无痴呆症的女性,年龄在70和92岁之间,研究人员对其随访五年。在研究开始和结束时,参与者参加了各种测试,包括记忆和思维能力的测试。在研究开始时447名参与者进行了CT脑扫描。

科学家们还研究了钙补充剂在参与者中的使用,以及他们在研究过程中是否被诊断为老年痴呆症。在研究开始时共有98名女性服用钙补充剂,54名女性已经患过卒中。在研究期间,多于54名女性患卒中,59名女性患痴呆症。经过CT扫描,71%的人有脑白质病变,这是脑血管病的一个标志性损伤。

这项研究发现,服用钙补充剂治疗的女性患痴呆症的几率是那些不服用补充剂女性的两倍。但当研究人员进一步分析这些数据时,他们发现,只有脑血管疾病的女性风险才会增加。对于有卒中史的女性,服用补充剂后患老年痴呆症的风险比不服用钙补充剂的女性患痴呆症的风险增加了近7倍。对于有脑白质病变的女性,服用补充剂后可能发展为老年痴呆症的风险是那些没有服用补充剂女性的3倍。无脑卒中病史或无脑白质病变的女性在服用钙补充剂后风险没有增加。

总体而言,在服用补充剂的98名女性中,14名女性(14%)发展为痴呆,而在没有服用补充剂的602名女性中,只有45名女性(8%)患老年痴呆。有卒中史并且服用补充剂的15名女性中,有6名女性患痴呆,在有卒中史并且没有服用补充剂93名女性中,只有12名女性患老年痴呆。在无卒中史的女性中,服用补充剂的83名女性中有18名女性发展为痴呆,而在没有服用补充剂的509名女性中,有33名女性发展为痴呆。

“需要注意的是我们的研究是观察性的,所以我们不能认为补钙会导致老年痴呆症,”Kern说。作者还指出,该研究规模较小,结果不能推广到整体人群,并且需要进一步的研究来证实该发现。

Kern指出,来自食物中钙对身体的影响不同于钙补充剂,并且看来是安全的,甚至对血管有保护作用。

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time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-10-18 yinhl1978
  2. 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    2016-10-08 ylzr123

    学习了,文章有深度,值得探究。

    0

  3. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Aug 26 01:06:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101996, encodeId=6fd410199675, content=学习了,了解了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Sun Aug 21 16:37:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101847, encodeId=db1010184e18, content=食补最安全, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160818/IMG57B58D810199D1909.jpg, createdBy=6e82110757, createdName=Kathyli, createdTime=Sun Aug 21 07:03:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316675, encodeId=d01f13166e553, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-10-08 ylzr123

    学习了,文章有深度,值得探究。

    0

  4. 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GetPortalCommentsPageByObjectIdResponse(id=101847, encodeId=db1010184e18, content=食补最安全, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160818/IMG57B58D810199D1909.jpg, createdBy=6e82110757, createdName=Kathyli, createdTime=Sun Aug 21 07:03:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316675, encodeId=d01f13166e553, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-09-03 李东泽

    很好,不错,以后会多学习

    0

  5. 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time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-26 李东泽

    这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

  6. 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beContent=null, objectType=article, channel=null, level=null, likeNumber=45, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Aug 26 01:06:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101996, encodeId=6fd410199675, content=学习了,了解了!, beContent=null, objectType=article, channel=null, level=null, likeNumber=20, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160817/IMG57B3C3F6DC2FD8753.jpg, createdBy=81321934679, createdName=1e0d99ddm02(暂无匿称), createdTime=Sun Aug 21 16:37:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=101847, encodeId=db1010184e18, content=食补最安全, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160818/IMG57B58D810199D1909.jpg, createdBy=6e82110757, createdName=Kathyli, createdTime=Sun Aug 21 07:03:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316675, encodeId=d01f13166e553, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-26 李东泽

    这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。

    0

  7. 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createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Sat Sep 03 00:04:00 CST 2016, time=2016-09-03, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104427, encodeId=e3b110442e70, content=这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, beContent=null, objectType=article, channel=null, level=null, likeNumber=59, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://wx.qlogo.cn/mmopen/jW482SpianMayicTRbRZ5RzUn81b5CF5ibVPib8jWI92iciaxmqGHlwruOnK4SVZykd4iahqo1hicklIibyZoxm55X7EM8BW9eX1h1hQ2/0, createdBy=8aa81937526, createdName=李东泽, createdTime=Fri Aug 26 11:32:00 CST 2016, time=2016-08-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=104018, encodeId=5a7110401833, content=这篇资讯写的真好,带给我们新知识,启发新思维,不论是科研还是临床工作都有很大的帮助。。。, 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GetPortalCommentsPageByObjectIdResponse(id=101847, encodeId=db1010184e18, content=食补最安全, beContent=null, objectType=article, channel=null, level=null, likeNumber=23, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=http://cacheapi.medsci.cn/resource/upload/20160818/IMG57B58D810199D1909.jpg, createdBy=6e82110757, createdName=Kathyli, createdTime=Sun Aug 21 07:03:00 CST 2016, time=2016-08-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1316675, encodeId=d01f13166e553, content=<a href='/topic/show?id=d3d0e121576' target=_blank style='color:#2F92EE;'>#痴呆风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=71215, encryptionId=d3d0e121576, topicName=痴呆风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a98f453, createdName=pcw106, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-21 1e0d99ddm02(暂无匿称)

    学习了,了解了!

    0

  8. 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time=2016-08-20, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1428746, encodeId=d6531428e46af, content=<a href='/topic/show?id=c9ae85106df' target=_blank style='color:#2F92EE;'>#脑血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=30, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=85106, encryptionId=c9ae85106df, topicName=脑血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=13c94134529, createdName=lfyang, createdTime=Sat Aug 20 11:47:00 CST 2016, time=2016-08-20, status=1, ipAttribution=)]
    2016-08-21 Kathyli

    食补最安全

    0

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