J INTERN MED:从未吸烟和曾经吸烟者哮喘、其他过敏性疾病和感染风险的关系!

2017-05-30 xing.T MedSci原创

由此可见,在从未吸烟和曾经吸烟的早期哮喘患者与任何感染、肺炎和任何非呼吸道感染的风险显著增加有关。在不吸烟者中,任何感染的风险估计和人口归因分数在哮喘和糖尿病之间是相当的,这表明哮喘可能是一般人群中感染的一个重大危险因素。

过敏性疾病个人可能会增加感染的易感性,在器官以外直接影响其过敏性疾病。近日,内科学领域权威杂志Journal of Internal Medicine上发表一篇研究文章。研究人员旨在验证一个假设,即整体过敏性疾病,根据吸烟史进行分层,与因感染而住院的风险增加相关。

研究人员收集了来自于一般人群的105519名个人吸烟史和自我报告的过敏性疾病信息,并对感染性疾病住院和死亡随访了长达23年。对于哮喘,研究人员将重点放在从不吸烟的并在50岁前诊断的哮喘患者(早期哮喘),以尽量减少受到慢性阻塞性肺疾病的影响。

随访期间,共有11160人发生了感染。不吸烟的早期哮喘患者相比于无过敏性疾病的患者任何感染(风险比为1.65;95%可信区间为1.40-1.94)、肺炎(2.44;1.92-3.11)以及任何非呼吸道感染(1.36;1.11-1.67)的风险显著增加;结果在既往吸烟者中相似。不吸烟者的任何哮喘患者显著增加任何感染(1.44;1.24-1.66)和肺炎(1.99;1.62-2.44)的风险。无论是特应性皮炎(1;0.91-1.10)还是花粉热(1;0.93-1.07)均与任何感染风险无关。在从不吸烟者中,对于哮喘和糖尿病患者任何感染的风险评估是相似的,因为所有哮喘人口可归因分数2.2%,而糖尿病为2.9%。

由此可见,在从未吸烟和曾经吸烟的早期哮喘患者与任何感染、肺炎和任何非呼吸道感染的风险显著增加有关。在不吸烟者中,任何感染的风险估计和人口归因分数在哮喘和糖尿病之间是相当的,这表明哮喘可能是一般人群中感染的一个重大危险因素。

原始出处:

Jens Helby,et al. Asthma, other atopic conditions and risk of infections in 105,519 general population never and ever smokers. J INTERN MED. 2017. http://onlinelibrary.wiley.com/doi/10.1111/joim.12635/full

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    2017-05-30 1e1275edm43(暂无匿称)

    哮喘增加感染几率,学习了

    0

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    2017-05-30 tanxingdoctor

    学习啦谢谢分享

    0

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    2017-05-30 jaysppr

    感谢梅斯医学!!

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