Stroke:自发性脑内出血重症监护患者长期死亡率的预测因素

2019-07-18 xing.T MedSci原创

在重症监护病房治疗的ICH患者中,临床因素对于12个月死亡率预测比客观影像学因素更为重要。对于幕上和幕下ICHs,临床和影像学因素对结局的影响是不同的,强调这些不应被视为同一种临床情况。

近日,心血管疾病领域权威杂志Stroke上发表了一篇研究文章,研究人员比较了需要重症监护的自发性脑出血(ICH)患者的长期死亡率的临床和影像学预测因子。 

2003年至2013年期间,研究人员对在芬兰三级医院重症监护室接受治疗的成年ICH患者进行了回顾性多中心研究,并创建了3个多变量模型(临床、影像学和临床影像学结合),用于12个月的死亡率预测,并比较了它们在受试者操作特征曲线下面积(AUC)。研究人员分别对幕上和幕下ICH进行了分析。

在972例患者(796例幕上ICH,176例幕下ICH)中,43%在12个月内死亡(42%为幕上ICH,49%为幕下ICH)。对于所有患者,临床模型(AUC为0.83; 95%CI为0.81-0.86)优于影像学模型(AUC为0.73; 95%CI为0.70-0.77; P<0.001),但临床影像学结合模型(AUC为0.85;95%CI为0.83-0.88)优于两个模型(P<0.001)。对于幕上ICH,临床影像学结合模型优于临床和影像学模型(AUC为0.84; 95%CI为0.81-0.87 vs. AUC为0.82; 95%CI为0.79-0.85和AUC为0.73; 95%CI为0.69-0.77;所有P<0.001)。对于幕下ICH患者,临床影像学结合模型显著优于影像学模型,但不优于临床模型(AUC为0.92; 95%CI为0.88-0.96 vs. AUC为0.76; 95%CI为0.69-0.83 vs. AUC为0.91; 95%CI为0.87-0.95;分别有P<0.001和P=0.433)。 

在重症监护病房治疗的ICH患者中,临床因素对于12个月死亡率预测比客观影像学因素更为重要。对于幕上和幕下ICHs,临床和影像学因素对结局的影响是不同的,强调这些不应被视为同一种临床情况。 

原始出处:

Marika Fallenius.et al.Spontaneous Intracerebral Hemorrhage Factors Predicting Long-Term Mortality After Intensive Care.stroke.2019.https://www.ahajournals.org/doi/10.1161/STROKEAHA.118.024560

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    2019-07-19 bioon6
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    2019-07-18 orangesking

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1810710, encodeId=f2121810e103b, content=<a href='/topic/show?id=8de1860949e' target=_blank style='color:#2F92EE;'>#自发性脑内出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86094, encryptionId=8de1860949e, topicName=自发性脑内出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d275294, createdName=andy2087, createdTime=Thu Jul 18 08:34:00 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2018151, encodeId=9fc820181515f, content=<a href='/topic/show?id=d0ca9596415' target=_blank style='color:#2F92EE;'>#重症监护患者#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=95964, encryptionId=d0ca9596415, topicName=重症监护患者)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73a3403, createdName=weihongyv, createdTime=Sun Jan 26 06:34:00 CST 2020, time=2020-01-26, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1971429, encodeId=fead19e142923, content=<a href='/topic/show?id=4b9884e10ed' target=_blank style='color:#2F92EE;'>#脑内出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=84710, encryptionId=4b9884e10ed, topicName=脑内出血)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=5319428, createdName=jjjiang0199, createdTime=Sat Feb 22 08:34:00 CST 2020, time=2020-02-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1264319, encodeId=e731126431962, content=<a href='/topic/show?id=daf1100226fb' target=_blank style='color:#2F92EE;'>#预测因素#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=100226, encryptionId=daf1100226fb, topicName=预测因素)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a57b78, createdName=朱睿睿, createdTime=Fri Jul 19 22:34:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1530594, encodeId=875d153059414, content=<a href='/topic/show?id=ed4a860e872' target=_blank style='color:#2F92EE;'>#自发性#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=86078, encryptionId=ed4a860e872, topicName=自发性)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=a12645, createdName=智智灵药, createdTime=Fri Jul 19 22:34:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1551160, encodeId=174e15511604a, content=<a href='/topic/show?id=e2c1e230796' target=_blank style='color:#2F92EE;'>#监护#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=26, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=72307, encryptionId=e2c1e230796, topicName=监护)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=477814173963, createdName=bioon6, createdTime=Fri Jul 19 22:34:00 CST 2019, time=2019-07-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369869, encodeId=7ecf36986952, content=好, beContent=null, objectType=article, channel=null, level=null, likeNumber=56, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=0aa31415219, createdName=orangesking, createdTime=Thu Jul 18 08:54:14 CST 2019, time=2019-07-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=369864, encodeId=7557369864ec, content=学习了,谢谢分享。, beContent=null, objectType=article, channel=null, level=null, likeNumber=72, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=00501987275, createdName=130****4638, createdTime=Thu Jul 18 07:59:28 CST 2019, time=2019-07-18, status=1, ipAttribution=)]
    2019-07-18 130****4638

    学习了,谢谢分享。

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