Stroke:动脉瘤性蛛网膜下腔出血(aSAH)后存在超额死亡率

2015-07-03 徐媛媛译 MedSci原创

动脉瘤性蛛网膜下腔出血(aSAH)具有非常高的病死率以及降低患者寿命,但与aSAH相关长期幸存患者数据非常缺乏。本文研究人员旨在评估aSAH事件发生后的长期超额死亡率和相关风险因素。 方法:这项顾性随访研究在1980-2007年间在赫尔辛基神经外科进行。在这项研究中,研究人员收纳了aSAH幸存≥1年的患者3078例,随访开始于aSAH后1年并随访至患者死亡或2012年底。使用相匹配的普通人群对死

动脉瘤性蛛网膜下腔出血(aSAH)具有非常高的病死率以及降低患者寿命,但与aSAH相关长期幸存患者数据非常缺乏。本文研究人员旨在评估aSAH事件发生后的长期超额死亡率和相关风险因素。

方法:这项顾性随访研究在1980-2007年间在赫尔辛基神经外科进行。在这项研究中,研究人员收纳了aSAH幸存≥1年的患者3078例,随访开始于aSAH后1年并随访至患者死亡或2012年底。使用相匹配的普通人群对死亡率和相对生存率进行推测。

研究显示,与普通人群相比,在aSAH幸存20年后,超额死亡率为17%。甚至年轻患者和恢复良好的患者也都显示有超额死亡率。最高超额死亡率出现在多发性动脉瘤、年龄较大、手术前临床状况差、保守动脉瘤治疗,以及在1年间有不良临床预后的患者。

结论:与相匹配的普通人群相比,即使是在aSAH后初始恢复良好的幸存者仍存在长期超额死亡率。在年轻时,患有心血管疾病和脑血管疾病的人群是导致死亡的重要原因,这也显示心血管风险因素治疗的重要性。应给予年轻患者和从aSAH中恢复的多发性动脉瘤患者更多的随访和更多积极治疗。

原始出处

Huhtakangas J1, Lehto H2, Seppä K2, Kivisaari R2, Niemelä M2, Hernesniemi J2, Lehecka M2.Long-Term Excess Mortality After Aneurysmal Subarachnoid Hemorrhage: Patients With Multiple Aneurysms at Risk.Stroke. 2015 Jul;

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    2016-01-19 yese
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    2015-09-06 lvygwyt2781
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    2015-07-08 保守主义

    应对措施呢?

    0

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    2015-07-05 zexyw03
  7. [GetPortalCommentsPageByObjectIdResponse(id=1654410, encodeId=b1f9165441090, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Thu Dec 31 12:01:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007795, encodeId=3283200e79566, content=<a href='/topic/show?id=da482812f3' target=_blank style='color:#2F92EE;'>#aSAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2812, encryptionId=da482812f3, topicName=aSAH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Jan 19 00:01:00 CST 2016, time=2016-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858438, encodeId=3e7d1858438e8, content=<a href='/topic/show?id=efd52810cc' target=_blank style='color:#2F92EE;'>#ASA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2810, encryptionId=efd52810cc, topicName=ASA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sun Sep 06 15:01:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31536, encodeId=dd173153617, content=应对措施呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Wed Jul 08 10:14:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337784, encodeId=bcb0133e78441, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460294, encodeId=0f57146029412, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30494, encodeId=b634304947e, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30495, encodeId=cd0d3049564, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30451, encodeId=3918304516e, content=动脉瘤真心可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51b9105133, createdName=qing1231990, createdTime=Sat Jul 04 11:12:00 CST 2015, time=2015-07-04, status=1, ipAttribution=)]
    2015-07-04 huaxipanxing

    看看

    0

  8. [GetPortalCommentsPageByObjectIdResponse(id=1654410, encodeId=b1f9165441090, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Thu Dec 31 12:01:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007795, encodeId=3283200e79566, content=<a href='/topic/show?id=da482812f3' target=_blank style='color:#2F92EE;'>#aSAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2812, encryptionId=da482812f3, topicName=aSAH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Jan 19 00:01:00 CST 2016, time=2016-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858438, encodeId=3e7d1858438e8, content=<a href='/topic/show?id=efd52810cc' target=_blank style='color:#2F92EE;'>#ASA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2810, encryptionId=efd52810cc, topicName=ASA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sun Sep 06 15:01:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31536, encodeId=dd173153617, content=应对措施呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Wed Jul 08 10:14:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337784, encodeId=bcb0133e78441, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460294, encodeId=0f57146029412, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30494, encodeId=b634304947e, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30495, encodeId=cd0d3049564, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30451, encodeId=3918304516e, content=动脉瘤真心可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51b9105133, createdName=qing1231990, createdTime=Sat Jul 04 11:12:00 CST 2015, time=2015-07-04, status=1, ipAttribution=)]
    2015-07-04 huaxipanxing

    看看

    0

  9. [GetPortalCommentsPageByObjectIdResponse(id=1654410, encodeId=b1f9165441090, content=<a href='/topic/show?id=5ab788e81d3' target=_blank style='color:#2F92EE;'>#蛛网膜#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=27, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=88781, encryptionId=5ab788e81d3, topicName=蛛网膜)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=396c24497244, createdName=aliceclz, createdTime=Thu Dec 31 12:01:00 CST 2015, time=2015-12-31, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2007795, encodeId=3283200e79566, content=<a href='/topic/show?id=da482812f3' target=_blank style='color:#2F92EE;'>#aSAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=32, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2812, encryptionId=da482812f3, topicName=aSAH)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=28d456, createdName=yese, createdTime=Tue Jan 19 00:01:00 CST 2016, time=2016-01-19, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1858438, encodeId=3e7d1858438e8, content=<a href='/topic/show?id=efd52810cc' target=_blank style='color:#2F92EE;'>#ASA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2810, encryptionId=efd52810cc, topicName=ASA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=947269, createdName=lvygwyt2781, createdTime=Sun Sep 06 15:01:00 CST 2015, time=2015-09-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=31536, encodeId=dd173153617, content=应对措施呢?, beContent=null, objectType=article, channel=null, level=null, likeNumber=106, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=d0f31631005, createdName=保守主义, createdTime=Wed Jul 08 10:14:00 CST 2015, time=2015-07-08, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1337784, encodeId=bcb0133e78441, content=<a href='/topic/show?id=376c332e497' target=_blank style='color:#2F92EE;'>#动脉瘤性蛛网膜下腔出血#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=33, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=33274, encryptionId=376c332e497, topicName=动脉瘤性蛛网膜下腔出血)], attachment=null, authenticateStatus=null, createdAvatar=http://thirdwx.qlogo.cn/mmopen/vi_32/UdV6ialcayj7Qv8RQm1mVfNYPKxjiaolxwglAZpCo6CwjTicOroW2Xb0Kxnc65viaxGpkuqHW7WzzbYgRLw3qooDoA/132, createdBy=04c22500137, createdName=紫砂壶, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1460294, encodeId=0f57146029412, content=<a href='/topic/show?id=de5015845be' target=_blank style='color:#2F92EE;'>#SAH#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=35, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=15845, encryptionId=de5015845be, topicName=SAH)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=f9f06287396, createdName=zexyw03, createdTime=Sun Jul 05 03:01:00 CST 2015, time=2015-07-05, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30494, encodeId=b634304947e, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=104, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30495, encodeId=cd0d3049564, content=看看, beContent=null, objectType=article, channel=null, level=null, likeNumber=100, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ee0d1618732, createdName=huaxipanxing, createdTime=Sat Jul 04 14:52:00 CST 2015, time=2015-07-04, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=30451, encodeId=3918304516e, content=动脉瘤真心可怕, beContent=null, objectType=article, channel=null, level=null, likeNumber=118, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=51b9105133, createdName=qing1231990, createdTime=Sat Jul 04 11:12:00 CST 2015, time=2015-07-04, status=1, ipAttribution=)]
    2015-07-04 qing1231990

    动脉瘤真心可怕

    0