JAHA:重症冠状病毒病患者心肌损伤危险因素

2020-06-30 MedSci原创 MedSci原创

老年(>70岁)、C反应蛋白大于100 mg/L、乳酸脱氢酶大于300 U/L和乳酸大于3 mmol/L是COVID-19危重患者心肌损害的高危因素。

新型严重急性呼吸系统综合症冠状病毒2(SARS-CoV-2)威胁人类健康,患有心肌损害的患者死亡率更高。但是,尚不完全了解2019冠状病毒病(COVID-19)患者心肌损伤的可能危险因素。

近日,血管疾病领域权威杂志JAHA上发表了一篇研究文章,研究人员从2020年2月1日至2020年2月24日在武汉大学人民医院204例确诊的COVID-19病例中随机选择危重型患者,并采用单因素分析比较两组:心肌损伤组和非心肌损伤组。

该研究总共招募了82名COVID-19危重患者:34名心肌损伤患者和48名无心肌损伤患者。心肌损伤组死亡病例30例,非心肌损伤组死亡病例20例。在单因素分析中,心肌损伤患者中老年患者(>70岁:70.59% vs. 37.50%; P=0.003)和心血管疾病患者(41.18% vs. 12.50%; P=0.003)的比例高于非心血管疾病患者。多变量分析显示年龄>70岁(HR为2.44,95%CI为1.01-5.40)、C反应蛋白超过100 mg/L(HR为1.92,95%CI为0.94-3.92)、乳酸脱氢酶大于300 U/L(HR为2.67,95%CI为1.03-6.90)和乳酸大于3 mmol/L(HR为3.25,95%CI为1.57-6.75)是COVID-19患者心肌损伤的独立危险因素。

由此可见,老年(>70岁)、C反应蛋白大于100 mg/L、乳酸脱氢酶大于300 U/L和乳酸大于3 mmol/L是COVID-19危重患者心肌损害的高危因素。

原始出处:

Lingzhi Li.et al.Retrospective Study of Risk Factors for Myocardial Damage in Patients with Critical Coronavirus Disease 2019, in Wuhan.JAHA.2020.https://www.ahajournals.org/doi/abs/10.1161/JAHA.120.016706

版权声明:
本网站所有内容来源注明为“梅斯医学”或“MedSci原创”的文字、图片和音视频资料,版权均属于梅斯医学所有。非经授权,任何媒体、网站或个人不得转载,授权转载时须注明来源为“梅斯医学”。其它来源的文章系转载文章,或“梅斯号”自媒体发布的文章,仅系出于传递更多信息之目的,本站仅负责审核内容合规,其内容不代表本站立场,本站不负责内容的准确性和版权。如果存在侵权、或不希望被转载的媒体或个人可与我们联系,我们将立即进行删除处理。
在此留言
评论区 (5)
#插入话题
  1. [GetPortalCommentsPageByObjectIdResponse(id=1268282, encodeId=fe29126828206, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310081, encodeId=10e1131008171, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397997, encodeId=086e139e997ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800646, encodeId=22f180064610, content=打卡, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200630/d48ccd0a87ee4e588501420de12569ce/8a863b7b2a934835bd7f6959cc60625f.jpg, createdBy=f47c5141590, createdName=1467943am98暂无昵称, createdTime=Tue Jun 30 22:48:34 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800641, encodeId=9f57800641aa, content=赚取积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73ac5259421, createdName=风湿免疫科医生, createdTime=Tue Jun 30 22:29:43 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
    2020-07-02 zhaohui6731
  2. [GetPortalCommentsPageByObjectIdResponse(id=1268282, encodeId=fe29126828206, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310081, encodeId=10e1131008171, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397997, encodeId=086e139e997ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800646, encodeId=22f180064610, content=打卡, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200630/d48ccd0a87ee4e588501420de12569ce/8a863b7b2a934835bd7f6959cc60625f.jpg, createdBy=f47c5141590, createdName=1467943am98暂无昵称, createdTime=Tue Jun 30 22:48:34 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800641, encodeId=9f57800641aa, content=赚取积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73ac5259421, createdName=风湿免疫科医生, createdTime=Tue Jun 30 22:29:43 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
  3. [GetPortalCommentsPageByObjectIdResponse(id=1268282, encodeId=fe29126828206, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310081, encodeId=10e1131008171, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397997, encodeId=086e139e997ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800646, encodeId=22f180064610, content=打卡, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200630/d48ccd0a87ee4e588501420de12569ce/8a863b7b2a934835bd7f6959cc60625f.jpg, createdBy=f47c5141590, createdName=1467943am98暂无昵称, createdTime=Tue Jun 30 22:48:34 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800641, encodeId=9f57800641aa, content=赚取积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73ac5259421, createdName=风湿免疫科医生, createdTime=Tue Jun 30 22:29:43 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
  4. [GetPortalCommentsPageByObjectIdResponse(id=1268282, encodeId=fe29126828206, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310081, encodeId=10e1131008171, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397997, encodeId=086e139e997ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800646, encodeId=22f180064610, content=打卡, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200630/d48ccd0a87ee4e588501420de12569ce/8a863b7b2a934835bd7f6959cc60625f.jpg, createdBy=f47c5141590, createdName=1467943am98暂无昵称, createdTime=Tue Jun 30 22:48:34 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800641, encodeId=9f57800641aa, content=赚取积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73ac5259421, createdName=风湿免疫科医生, createdTime=Tue Jun 30 22:29:43 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
    2020-06-30 1467943am98暂无昵称

    打卡

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1268282, encodeId=fe29126828206, content=<a href='/topic/show?id=922f21183d' target=_blank style='color:#2F92EE;'>#AHA#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=58, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=2118, encryptionId=922f21183d, topicName=AHA)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=bf3d82, createdName=zhaohui6731, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1310081, encodeId=10e1131008171, content=<a href='/topic/show?id=ddd95126e4e' target=_blank style='color:#2F92EE;'>#心肌损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=42, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=51267, encryptionId=ddd95126e4e, topicName=心肌损伤)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4723380, createdName=yangcx0915, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1397997, encodeId=086e139e997ef, content=<a href='/topic/show?id=8bee565436d' target=_blank style='color:#2F92EE;'>#损伤#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=44, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=56543, encryptionId=8bee565436d, topicName=损伤)], attachment=null, authenticateStatus=null, createdAvatar=https://thirdwx.qlogo.cn/mmopen/vi_32/DYAIOgq83eoNX3lUOlDKGBUEPNwZx0nibmdcFyeibnX4WMhUSCU2REpGRWtSmnT2CCs0dA5waxvJknYDxwtYnIcQ/132, createdBy=294e2500218, createdName=ms3046638856685384, createdTime=Thu Jul 02 12:58:21 CST 2020, time=2020-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800646, encodeId=22f180064610, content=打卡, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=https://img.medsci.cn/20200630/d48ccd0a87ee4e588501420de12569ce/8a863b7b2a934835bd7f6959cc60625f.jpg, createdBy=f47c5141590, createdName=1467943am98暂无昵称, createdTime=Tue Jun 30 22:48:34 CST 2020, time=2020-06-30, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=800641, encodeId=9f57800641aa, content=赚取积分, beContent=null, objectType=article, channel=null, level=null, likeNumber=99, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=73ac5259421, createdName=风湿免疫科医生, createdTime=Tue Jun 30 22:29:43 CST 2020, time=2020-06-30, status=1, ipAttribution=)]
    2020-06-30 风湿免疫科医生

    赚取积分

    0

相关资讯

Clin Exp Rheumatol:系统性红斑狼疮患者肺栓塞的特征和危险因素

这项研究提供了基于人群的一般证据,表明SLE患者发生PE的风险升高。

Semin Arthritis Rheu:系统性红斑狼疮儿童和成人患者的心衰危险因素研究

高血压仍然是所有年龄段的重要传统心血管风险因素,即使在年轻的SLE患者中也应积极控制。

Chest:有创机械通气后ICU患者吞咽困难的危险因素

基础神经系统疾病、急诊入院和有创机械通气时间是吞咽困难的重要独立危险因素。由于所有机械通气后的ICU患者都应考虑有吞咽困难的风险,因此建议对各个危重患者进行吞咽困难的系统筛查。

Crit Care Med:重症成人睡眠紊乱的危险因素

该系统评价总结了与ICU患者睡眠紊乱相关的所有病前的、疾病相关和ICU相关因素。这些发现将有助于促进ICU患者睡眠改善。

Circulation:COVID-19住院患者深静脉血栓形成的患病率、危险因素和结局

COVID-19住院患者DVT的患病率很高,并且与其不良结局有关。入院后帕多瓦预测评分≥4的患者接受预防静脉血栓栓塞治疗具有保护性效应。该研究的数据表明COVID-19可能是住院患者发生DVT的一个危

Chest:类风湿性关节炎一系列间质性肺部异常的基线特征和进展

病变位于胸膜下和基线ILA/ILD范围大是与进展相关的危险因素。