Semin Arthritis Rheu:中轴型脊柱关节炎中骨质疏松和骨折的患病率及危险因素

2018-01-04 xiangting MedSci原创

对Ax-SpA患者的骨质疏松症评估中,应考虑饮酒、使用类固醇以及低水平25-OH-维生素D。

这篇文章旨在描述中轴型脊柱关节炎(Ax-SpA)中骨质疏松症的患病率,骨折的患病率和发病率以及低骨密度(BMD)危险因素的频率。

研究人员对观察性研究进行了系统综述和meta分析。使用敏感策略检索Medline、Embase和Cochrane Library数据库。入选过去10年(2006年1月-2016年)发表的评估Ax-SpA患者骨质疏松频率、危险因素或骨折并具有代表性患者样本的大型横断面和纵向研究。

在筛选了3597个标题和摘要后,对46项研究进行了详细审查,其中35项为横断面设计,5项为前瞻性,6项为回顾性。21项研究将Ax-SpA患者与对照组(健康个体(18项研究)或其他疾病受试者(6项研究))进行了比较。骨质疏松症的患病率为11.7%-34.4%不等,骨折患病率为11%-24.6%。Ax-SpA患者中饮酒(58-61%),使用皮质类固醇(11.7-66.9%)和25-OH维生素D缺乏(26-76%)出乎意料地高。

Ax-SpA中骨质疏松症和骨折的患病率分别为11.7%-34.4%不等和11-24.6%。对Ax-SpA患者的骨质疏松症评估中,应考虑饮酒、使用类固醇以及低水平25-OH-维生素D。结果不一致,缺乏骨质评估以及已发表研究的偏倚可能性高,这证实了进行设计良好研究的必要性。

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    2018-01-06 zhaojie88
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    2018-01-06 Eleven17

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