J Rheumatol:妊娠对银屑病关节炎患者疾病活动性的影响

2018-09-19 xiangting MedSci原创

继续生物制剂治疗与妊娠期间疾病活动性水平低、急性发作可能性低相关。

这项研究旨在评价妊娠对银屑病关节炎(PsA)疾病活动性的影响。

这是一个回顾性的病例系列。审查在两个医疗中心PsA门诊随访的所有女性患者的病历,以确定随访期间至少怀孕1次,并在妊娠期间或妊娠后不久就诊1次的女性患者。

共纳入25名女性PsA患者(来自在PsA门诊随访的107名育龄女性)和35次妊娠。33次妊娠为健康活产。整个组中,妊娠期间疾病活动性没有显著变化,而16次妊娠(48%),患者在产后第一年的病情恶化。21次妊娠中有15次,女性在受孕前接受了生物制剂治疗,并在备孕期或妊娠头三个月停止了治疗。这15名患者中有5名在妊娠前被分类为轻至重度PsA活动性。在孕早期、孕中期和产后这个数字分别增加至8、9和14。6名使用生物制剂至孕早期患者的疾病活动性程度没有显著变化。非生物制剂治疗患者妊娠期间的疾病活动性有所改善。6次妊娠中开始使用糖皮质激素或增加剂量,并且均为妊娠前停用生物制剂的患者。

继续生物制剂治疗与妊娠期间疾病活动性水平低、急性发作可能性低相关。妊娠前停止生物制剂治疗与妊娠期、产后的急性发作相关。

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    2018-09-21 lmm397

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