JCEM:特纳综合征女孩骨折的发生率!

2017-12-30 xing.T MedSci原创

由此可见,目前使用生长激素和雌激素治疗的TS患儿并不会增加骨质疏松性骨折的风险。TS患者较低的BMD可通过增加骨骼半径来抵消,使四肢骨骼得到正常的骨强度。

特纳综合征(TS)患者存在骨质疏松性骨折的风险。近日,内分泌和代谢性疾病领域权威杂志Journal of Clinical Endocrinology & Metabolism上发表了一篇研究文章,研究人员旨在评估TS女孩临床骨折的发生率,并前瞻性地描述体积骨密度(BMD)的发育。

在6年的观察期间每隔一年进行外周定量CT(pQCT)检查。该研究以政府资助大学的转诊中心为基础,参与者为三十二个6-16岁的TS女孩。这些参与者的骨密度和强度与185名健康女孩的数据进行比较。骨折发生率与一般人群的数据进行了比较。该研究的主要临床结局为骨折的发生。次要结局为骨参数Z值的变化。

研究人员发现有三个TS女孩在6年观察期间发生持续性的四次骨折。TS组的骨折率没有显著高于年龄匹配的健康对照组估计的骨折率(P=0.48)。而随着年龄的增长骨密度Z值有所下降(估计下降0.21±0.04,P<0.001),骨骼总截面积相应增加(增加0.16±0.04,P<0.001),导致骨强度正常。骨折史并不与任何pQCT衍生的骨骼参数显著相关。

由此可见,目前使用生长激素和雌激素治疗的TS患儿并不会增加骨质疏松性骨折的风险。TS患者较低的BMD可通过增加骨骼半径来抵消,使四肢骨骼得到正常的骨强度。

原始出处:


Ondrej Soucek,et al. A 6-Year Follow-Up of Fracture Incidence and Volumetric Bone Mineral Density Development in Girls with Turner Syndrome.J Clin Endocrinol Metab. 2017. https://doi.org/10.1210/jc.2017-02381

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    2018-06-22 smallant2015
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    2018-10-30 achengzhao
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    2018-01-04 wzb521zf

    一起学习学习

    0

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    2018-01-01 wqkm

    ^_^^_^^_^^_^^_^

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    2018-01-01 wqkm

    ^_^^_^^_^^_^^_^^_^

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    2017-12-31 1371f3708cm

    学习了

    0

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