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Calcif Tissue Int：成骨不全症与早发性骨质疏松症的骨微结构比较

2018-06-30 MedSci MedSci原创

关注

https://www.ncbi.nlm.nih.gov/pubmed/29946973

50岁以前低骨量和骨脆性增加的成人个体的诊断和治疗可能具有挑战性。许多这些患者通过检测COL1A1或COL1A2突变被诊断为轻度成骨不全（OI），然而，早发性骨质疏松症（EOOP）的临床分化可能很困难。本研究旨在确定轻度OI和EOOP患者之间的骨显微结构差异。

29名COL1A1或COL1A2中突变的患者被分类为OI。骨骼评估包括双能X线骨密度仪（DXA），高分辨率外周定量计算机断层扫描（HR-pQCT）和骨转换血清分析。评估21/29例OI患者的骨显微结构，并与23例年龄和性别匹配的临床分类EOOP患者进行比较。

结果显示，在OI患者中，并未观察到DXA Z评分的年龄依赖性降低。与健康对照组相比，HR-pQCT显示OI和EOOP队列中桡骨远端和胫骨的体积BMD和微结构参数明显降低。比较OI患者的骨显微结构和EOOP队列时，骨几何形状方面存在明显差异，而在其他HR-pQCT参数中未检测到明显变化。

总之，该研究结果表明，成人轻度OI患者表现出明显的高骨转换骨小梁骨丢失综合征，与没有突变的EOOP相比，显示出微小的显微结构差异。

原始出处：

Rolvien T, Stürznickel J, et al., Comparison of Bone Microarchitecture Between Adult Osteogenesis Imperfecta and Early-Onset Osteoporosis. Calcif Tissue Int. 2018 Jun 26. doi: 10.1007/s00223-018-0447-8.

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    2018-12-24 zhaojie88

    #Tissue#

    0

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    2019-02-28 ms7258648636991762

    #早发#

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    2019-03-10 cmj8wellington

    #微结构#

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    2018-07-02 zhaojie88

    #成骨#

    0

  5. [GetPortalCommentsPageByObjectIdResponse(id=1911356, encodeId=d7db191135662, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 24 17:40:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664061, encodeId=6ab8166406166, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Thu Feb 28 19:40:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027023, encodeId=68fa202e023b2, content=<a href='/topic/show?id=e51050e5695' target=_blank style='color:#2F92EE;'>#微结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50756, encryptionId=e51050e5695, topicName=微结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 10 01:40:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351761, encodeId=dd201351e618e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543134, encodeId=e9ec15431346e, content=<a href='/topic/show?id=cd3754094de' target=_blank style='color:#2F92EE;'>#成骨不全症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54094, encryptionId=cd3754094de, topicName=成骨不全症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb313545134, createdName=124987e8m11暂无昵称, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592470, encodeId=0e7815924e09e, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328339, encodeId=a81e32833973, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 01 06:36:35 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-02 124987e8m11暂无昵称

    #成骨不全症#

    0

  6. [GetPortalCommentsPageByObjectIdResponse(id=1911356, encodeId=d7db191135662, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 24 17:40:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664061, encodeId=6ab8166406166, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Thu Feb 28 19:40:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027023, encodeId=68fa202e023b2, content=<a href='/topic/show?id=e51050e5695' target=_blank style='color:#2F92EE;'>#微结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50756, encryptionId=e51050e5695, topicName=微结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 10 01:40:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351761, encodeId=dd201351e618e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543134, encodeId=e9ec15431346e, content=<a href='/topic/show?id=cd3754094de' target=_blank style='color:#2F92EE;'>#成骨不全症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54094, encryptionId=cd3754094de, topicName=成骨不全症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb313545134, createdName=124987e8m11暂无昵称, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592470, encodeId=0e7815924e09e, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328339, encodeId=a81e32833973, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 01 06:36:35 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-02 Eleven17

    #骨质#

    0

  7. [GetPortalCommentsPageByObjectIdResponse(id=1911356, encodeId=d7db191135662, content=<a href='/topic/show?id=df471e4882e' target=_blank style='color:#2F92EE;'>#Tissue#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=28, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=17488, encryptionId=df471e4882e, topicName=Tissue)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Dec 24 17:40:00 CST 2018, time=2018-12-24, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1664061, encodeId=6ab8166406166, content=<a href='/topic/show?id=a20c59283e5' target=_blank style='color:#2F92EE;'>#早发#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=36, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=59283, encryptionId=a20c59283e5, topicName=早发)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=06c425715601, createdName=ms7258648636991762, createdTime=Thu Feb 28 19:40:00 CST 2019, time=2019-02-28, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=2027023, encodeId=68fa202e023b2, content=<a href='/topic/show?id=e51050e5695' target=_blank style='color:#2F92EE;'>#微结构#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=17, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=50756, encryptionId=e51050e5695, topicName=微结构)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=c689267, createdName=cmj8wellington, createdTime=Sun Mar 10 01:40:00 CST 2019, time=2019-03-10, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1351761, encodeId=dd201351e618e, content=<a href='/topic/show?id=e95954093cd' target=_blank style='color:#2F92EE;'>#成骨#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=25, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54093, encryptionId=e95954093cd, topicName=成骨)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=4c37265, createdName=zhaojie88, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1543134, encodeId=e9ec15431346e, content=<a href='/topic/show?id=cd3754094de' target=_blank style='color:#2F92EE;'>#成骨不全症#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=29, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=54094, encryptionId=cd3754094de, topicName=成骨不全症)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ceb313545134, createdName=124987e8m11暂无昵称, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1592470, encodeId=0e7815924e09e, content=<a href='/topic/show?id=6dc2101853ed' target=_blank style='color:#2F92EE;'>#骨质#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=19, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=101853, encryptionId=6dc2101853ed, topicName=骨质)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=e1d018108513, createdName=Eleven17, createdTime=Mon Jul 02 14:40:00 CST 2018, time=2018-07-02, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=328339, encodeId=a81e32833973, content=学习学习.继续关注, beContent=null, objectType=article, channel=null, level=null, likeNumber=34, replyNumber=0, topicName=null, topicId=null, topicList=[], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=93f31631454, createdName=1dd8c52fm63(暂无匿称), createdTime=Sun Jul 01 06:36:35 CST 2018, time=2018-07-01, status=1, ipAttribution=)]
    2018-07-01 1dd8c52fm63(暂无匿称)

    学习学习.继续关注

    0